Sodium in PDB 3s9o: The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis

Enzymatic activity of The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis

All present enzymatic activity of The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis:
2.7.10.2;

Protein crystallography data

The structure of The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis, PDB code: 3s9o was solved by S.T.Arold, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	30.43 / 2.60
*Space group*	C 2 2 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	89.918, 223.983, 98.015, 90.00, 90.00, 90.00
*R / R_free (%)*	23.3 / 28.7

Other elements in 3s9o:

The structure of The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis (pdb code 3s9o). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis, PDB code: 3s9o:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in 3s9o

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Sodium Binding Sites List in 3s9o

Sodium binding site 1 out of 2 in the The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis

Mono view

Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Na34 b:76.8 occ:1.00	N	A:ALA977	3.0	75.3	1.0
	CA	A:PRO976	3.1	71.8	1.0
	C	A:PRO976	3.5	72.8	1.0
	CB	A:PRO976	3.8	72.2	1.0
	CA	A:ALA977	4.2	76.1	1.0
	CB	A:ALA977	4.2	78.7	1.0
	N	A:PRO976	4.2	69.1	1.0
	O	A:LEU975	4.4	67.8	1.0
	C	A:LEU975	4.6	67.4	1.0
	O	A:PRO976	4.7	72.0	1.0
	CG	A:PRO976	4.8	70.7	1.0

Sodium binding site 2 out of 2 in 3s9o

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Sodium Binding Sites List in 3s9o

Sodium binding site 2 out of 2 in the The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis

Mono view

Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of The Focal Adhesion Targeting (Fat) Domain of the Focal Adhesion Kinase Showing N-Terminal Interactions in Cis within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
C:Na35 b:16.2 occ:0.50	N	C:ALA977	3.5	73.9	1.0
	O	C:HOH22	3.8	27.3	1.0
	O	C:LEU975	3.9	70.8	1.0
	C	C:PRO976	4.1	71.3	1.0
	CB	C:ALA977	4.2	78.7	1.0
	CA	C:PRO976	4.2	70.5	1.0
	CA	C:ALA977	4.2	75.1	1.0
	C	C:LEU975	4.7	68.7	1.0
	O	C:PRO973	4.7	76.5	1.0
	N	C:PRO976	4.9	68.3	1.0
	O	C:PRO976	5.0	69.3	1.0

Reference:

G.Kadare, N.Gervasi, K.Brami-Cherrier, H.Blockus, S.El Messari, S.T.Arold, J.A.Girault. Conformational Dynamics of the Focal Adhesion Targeting Domain Control Specific Functions of Focal Adhesion Kinase in Cells. J.Biol.Chem. V. 290 478 2015.
ISSN: ISSN 0021-9258
PubMed: 25391654
DOI: 10.1074/JBC.M114.593632

Page generated: Tue Dec 15 06:24:30 2020

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