Sodium in PDB 3bpr: Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52

Enzymatic activity of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52

All present enzymatic activity of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52, PDB code: 3bpr was solved by J.R.Walker, X.Huang, P.J.Finerty Jr, J.Weigelt, C.H.Arrowsmith, A.M.Edwards, A.Bochkarev, S.Dhe-Paganon, Structural Genomics Consortium(Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	47.30 / 2.80
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	70.001, 91.702, 120.745, 90.00, 94.06, 90.00
*R / R_free (%)*	27.4 / 30.1

Other elements in 3bpr:

The structure of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52 also contains other interesting chemical elements:

Chlorine

(Cl)

6 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52 (pdb code 3bpr). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52, PDB code: 3bpr:

Sodium binding site 1 out of 1 in 3bpr

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Sodium Binding Sites List in 3bpr

Sodium binding site 1 out of 1 in the Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52

Mono view

Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Catalytic Domain of the Proto-Oncogene Tyrosine- Protein Kinase Mer in Complex with Inhibitor C52 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:Na1 b:35.1 occ:1.00	OE1	A:GLU823	2.5	60.2	1.0
	O	B:SER686	2.7	53.2	1.0
	O	B:LEU688	2.8	56.8	1.0
	O	B:PRO692	3.0	55.0	1.0
	CD	A:GLU823	3.3	60.7	1.0
	O	A:HOH119	3.4	36.9	1.0
	C	B:SER686	3.5	50.2	1.0
	OE2	A:GLU823	3.5	62.8	1.0
	C	B:LEU688	3.6	57.9	1.0
	N	B:HIS694	3.7	60.7	1.0
	C	B:LYS693	3.8	59.9	1.0
	O	B:GLY691	3.8	60.6	1.0
	C	B:PRO692	3.9	56.9	1.0
	CA	B:LYS693	4.0	62.2	1.0
	N	B:LEU688	4.1	52.3	1.0
	CA	B:SER686	4.1	48.3	1.0
	N	B:GLU689	4.3	61.9	1.0
	N	B:ARG687	4.3	50.1	1.0
	N	B:LYS693	4.4	60.7	1.0
	O	B:LYS693	4.4	57.8	1.0
	C	B:ARG687	4.4	52.0	1.0
	CA	B:HIS694	4.4	60.1	1.0
	CA	B:LEU688	4.5	56.0	1.0
	O	B:TYR685	4.5	52.2	1.0
	CG	A:GLU823	4.5	58.5	1.0
	CA	B:GLU689	4.5	64.8	1.0
	C	B:GLY691	4.6	58.2	1.0
	CA	B:ARG687	4.6	51.2	1.0
	CB	A:GLU823	4.8	55.0	1.0
	CB	B:SER686	5.0	48.3	1.0

Reference:

X.Huang, P.Finerty, J.R.Walker, C.Butler-Cole, M.Vedadi, M.Schapira, S.A.Parker, B.E.Turk, D.A.Thompson, S.Dhe-Paganon. Structural Insights Into the Inhibited States of the Mer Receptor Tyrosine Kinase. J.Struct.Biol. V. 165 88 2009.
ISSN: ISSN 1047-8477
PubMed: 19028587
DOI: 10.1016/J.JSB.2008.10.003

Page generated: Mon Oct 7 06:06:07 2024

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