Sodium in PDB 2xzk: The Aspergillus Fumigatus Sialidase Is A Kdnase: Structural and Mechanistic Insights

All present enzymatic activity of The Aspergillus Fumigatus Sialidase Is A Kdnase: Structural and Mechanistic Insights:
3.2.1.18;

The structure of The Aspergillus Fumigatus Sialidase Is A Kdnase: Structural and Mechanistic Insights, PDB code: 2xzk was solved by J.C.Telford, J.H.F.Yeung, M.J.Kiefel, A.G.Watts, S.Hader, J.Chan, A.J.Bennet, M.M.Moore, G.L.Taylor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	31.01 / 1.50
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	75.680, 58.080, 94.450, 90.00, 100.05, 90.00
R / Rfree (%)	17.923 / 21.375

The structure of The Aspergillus Fumigatus Sialidase Is A Kdnase: Structural and Mechanistic Insights also contains other interesting chemical elements:

Fluorine	(F)	12 atoms
Chlorine	(Cl)	2 atoms

The binding sites of Sodium atom in the The Aspergillus Fumigatus Sialidase Is A Kdnase: Structural and Mechanistic Insights (pdb code 2xzk). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the The Aspergillus Fumigatus Sialidase Is A Kdnase: Structural and Mechanistic Insights, PDB code: 2xzk:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the The Aspergillus Fumigatus Sialidase Is A Kdnase: Structural and Mechanistic Insights


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of The Aspergillus Fumigatus Sialidase Is A Kdnase: Structural and Mechanistic Insights within 5.0Å range: probe atom residue distance (Å) B Occ A:Na505 b:12.9 occ:1.00 OD1 A:ASP87 2.3 15.4 1.0 O A:HOH2165 2.3 15.9 1.0 O A:GLY116 2.3 15.5 1.0 O A:GLY118 2.3 17.0 1.0 OD1 A:ASN89 2.4 13.8 1.0 O A:HOH2158 2.6 29.7 1.0 CG A:ASP87 3.3 14.3 1.0 C A:GLY116 3.4 14.6 1.0 CG A:ASN89 3.5 11.8 1.0 C A:GLY118 3.6 16.0 1.0 OD2 A:ASP87 3.6 17.6 1.0 ND2 A:ASN89 3.8 13.3 1.0 CA A:GLY116 4.0 13.6 1.0 N A:GLY118 4.3 16.4 1.0 C A:SER117 4.3 16.5 1.0 N A:SER117 4.4 15.6 1.0 CA A:ALA119 4.4 15.0 1.0 N A:ALA119 4.4 15.4 1.0 O A:SER117 4.5 16.5 1.0 CA A:GLY118 4.5 16.2 1.0 O A:ILE88 4.6 9.7 1.0 O A:GLY120 4.6 11.6 1.0 CB A:ASP87 4.7 11.9 1.0 O A:HOH2096 4.7 44.9 1.0 CA A:SER117 4.8 16.3 1.0 CB A:ASN89 4.8 9.6 1.0 C A:ILE88 4.8 9.3 1.0 N A:ILE88 4.8 10.1 1.0 CA A:ASP87 5.0 11.2 1.0 C A:ALA119 5.0 14.4 1.0

Sodium binding site 2 out of 2 in the The Aspergillus Fumigatus Sialidase Is A Kdnase: Structural and Mechanistic Insights


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of The Aspergillus Fumigatus Sialidase Is A Kdnase: Structural and Mechanistic Insights within 5.0Å range: probe atom residue distance (Å) B Occ B:Na507 b:8.4 occ:1.00 O B:GLY118 2.3 16.8 1.0 OD1 B:ASP87 2.4 15.1 1.0 O B:GLY116 2.4 14.9 1.0 OD1 B:ASN89 2.4 12.7 1.0 O B:HOH2143 2.6 24.1 1.0 C B:GLY116 3.5 14.2 1.0 CG B:ASP87 3.5 14.0 1.0 CG B:ASN89 3.5 10.3 1.0 C B:GLY118 3.6 16.2 1.0 OD2 B:ASP87 3.8 18.0 1.0 ND2 B:ASN89 3.9 9.9 1.0 CA B:GLY116 4.1 13.2 1.0 O B:HOH2196 4.1 33.7 1.0 C B:SER117 4.3 16.4 1.0 N B:GLY118 4.3 16.2 1.0 O B:SER117 4.4 15.8 1.0 CA B:ALA119 4.4 14.8 1.0 N B:ALA119 4.4 15.6 1.0 N B:SER117 4.5 15.3 1.0 O B:GLY120 4.5 11.7 1.0 CA B:GLY118 4.6 16.3 1.0 O B:ILE88 4.6 7.4 1.0 O B:HOH2195 4.7 27.0 1.0 CB B:ASP87 4.8 11.0 1.0 N B:ILE88 4.8 9.2 1.0 CA B:SER117 4.8 16.2 1.0 C B:ILE88 4.8 7.7 1.0 CB B:ASN89 4.8 8.9 1.0 O B:HOH2136 4.9 25.0 1.0 C B:ALA119 4.9 14.2 1.0 CA B:ASP87 5.0 10.3 1.0

J.C.Telford, J.H.F.Yeung, G.Xu, M.J.Kiefel, A.G.Watts, S.Hader, J.Chan, A.J.Bennet, M.M.Moore, G.L.Taylor. The Aspergillus Fumigatus Sialidase Is A Kdnase: Structural and Mechanistic Insights. J.Biol.Chem. V. 286 10783 2011.
ISSN: ISSN 0021-9258
PubMed: 21247893
DOI: 10.1074/JBC.M110.207043