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Sodium in PDB 2uvm: Structure of Pkbalpha pH Domain in Complex with A Novel Inositol Headgroup Surrogate, Benzene 1,2,3,4- Tetrakisphosphate

Enzymatic activity of Structure of Pkbalpha pH Domain in Complex with A Novel Inositol Headgroup Surrogate, Benzene 1,2,3,4- Tetrakisphosphate

All present enzymatic activity of Structure of Pkbalpha pH Domain in Complex with A Novel Inositol Headgroup Surrogate, Benzene 1,2,3,4- Tetrakisphosphate:
2.7.11.1;

Protein crystallography data

The structure of Structure of Pkbalpha pH Domain in Complex with A Novel Inositol Headgroup Surrogate, Benzene 1,2,3,4- Tetrakisphosphate, PDB code: 2uvm was solved by D.Komander, S.J.Mills, M.N.Trusselle, S.T.Safrany, D.M.F.Van Aalten, B.V.L.Potter, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 14.98 / 1.94
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 80.029, 34.040, 44.944, 90.00, 112.25, 90.00
R / Rfree (%) 25.2 / 26.9

Sodium Binding Sites:

The binding sites of Sodium atom in the Structure of Pkbalpha pH Domain in Complex with A Novel Inositol Headgroup Surrogate, Benzene 1,2,3,4- Tetrakisphosphate (pdb code 2uvm). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Structure of Pkbalpha pH Domain in Complex with A Novel Inositol Headgroup Surrogate, Benzene 1,2,3,4- Tetrakisphosphate, PDB code: 2uvm:

Sodium binding site 1 out of 1 in 2uvm

Go back to Sodium Binding Sites List in 2uvm
Sodium binding site 1 out of 1 in the Structure of Pkbalpha pH Domain in Complex with A Novel Inositol Headgroup Surrogate, Benzene 1,2,3,4- Tetrakisphosphate


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Structure of Pkbalpha pH Domain in Complex with A Novel Inositol Headgroup Surrogate, Benzene 1,2,3,4- Tetrakisphosphate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na1117

b:19.9
occ:1.00
OAU A:GVF1116 2.2 25.2 1.0
OAV A:GVF1116 2.3 20.2 1.0
OAR A:GVF1116 3.1 20.3 1.0
PAW A:GVF1116 3.2 20.1 1.0
O A:HOH2053 3.2 27.1 1.0
PAT A:GVF1116 3.2 24.8 1.0
OAQ A:GVF1116 3.5 22.0 1.0
OAX A:GVF1116 3.8 20.1 1.0
OAS A:GVF1116 3.9 26.4 1.0
CAO A:GVF1116 4.1 20.8 1.0
CAP A:GVF1116 4.2 20.2 1.0
NH2 A:ARG23 4.2 17.4 1.0
OAZ A:GVF1116 4.5 20.2 1.0
OAY A:GVF1116 4.6 27.6 1.0

Reference:

S.J.Mills, D.Komander, M.N.Trusselle, S.T.Safrany, D.M.F.Van Aalten, B.V.L.Potter. Novel Inositol Phospholipid Headgroup Surrogate Crystallised in the Pleckstrin Homology Domain of Protein Kinase Balpha. Acs Chem.Biol. V. 2 242 2007.
ISSN: ISSN 1554-8929
PubMed: 17432822
DOI: 10.1021/CB700019R
Page generated: Tue Dec 15 05:56:09 2020

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