Sodium in PDB 2tys: Crystal Structures of Mutant (BETAK87T) Tryptophan Synthase ALPHA2 BETA2 Complex with Ligands Bound to the Active Sites of the Alpha and Beta Subunits Reveal Ligand-Induced Conformational Changes

Enzymatic activity of Crystal Structures of Mutant (BETAK87T) Tryptophan Synthase ALPHA2 BETA2 Complex with Ligands Bound to the Active Sites of the Alpha and Beta Subunits Reveal Ligand-Induced Conformational Changes

All present enzymatic activity of Crystal Structures of Mutant (BETAK87T) Tryptophan Synthase ALPHA2 BETA2 Complex with Ligands Bound to the Active Sites of the Alpha and Beta Subunits Reveal Ligand-Induced Conformational Changes:
4.2.1.20;

Protein crystallography data

The structure of Crystal Structures of Mutant (BETAK87T) Tryptophan Synthase ALPHA2 BETA2 Complex with Ligands Bound to the Active Sites of the Alpha and Beta Subunits Reveal Ligand-Induced Conformational Changes, PDB code: 2tys was solved by S.Rhee, K.D.Parris, C.C.Hyde, S.A.Ahmed, E.W.Miles, D.R.Davies, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	8.00 / 1.90
*Space group*	C 1 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	185.800, 62.300, 67.800, 90.00, 94.10, 90.00
*R / R_free (%)*	n/a / n/a

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structures of Mutant (BETAK87T) Tryptophan Synthase ALPHA2 BETA2 Complex with Ligands Bound to the Active Sites of the Alpha and Beta Subunits Reveal Ligand-Induced Conformational Changes (pdb code 2tys). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structures of Mutant (BETAK87T) Tryptophan Synthase ALPHA2 BETA2 Complex with Ligands Bound to the Active Sites of the Alpha and Beta Subunits Reveal Ligand-Induced Conformational Changes, PDB code: 2tys:

Sodium binding site 1 out of 1 in 2tys

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Sodium Binding Sites List in 2tys

Sodium binding site 1 out of 1 in the Crystal Structures of Mutant (BETAK87T) Tryptophan Synthase ALPHA2 BETA2 Complex with Ligands Bound to the Active Sites of the Alpha and Beta Subunits Reveal Ligand-Induced Conformational Changes

Mono view

Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structures of Mutant (BETAK87T) Tryptophan Synthase ALPHA2 BETA2 Complex with Ligands Bound to the Active Sites of the Alpha and Beta Subunits Reveal Ligand-Induced Conformational Changes within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:Na400 b:21.1 occ:1.00	O	B:SER308	2.3	19.3	1.0
	O	B:HOH401	2.3	16.1	1.0
	O	B:HOH402	2.4	18.0	1.0
	O	B:GLY232	2.4	20.1	1.0
	O	B:PHE306	2.4	17.5	1.0
	C	B:GLY232	3.5	18.0	1.0
	C	B:SER308	3.6	16.1	1.0
	C	B:PHE306	3.6	17.3	1.0
	O	B:GLY268	3.9	18.2	1.0
	CG	B:PRO270	3.9	22.3	1.0
	CD	B:PRO270	4.0	20.5	1.0
	CA	B:GLY232	4.0	10.0	1.0
	N	B:SER308	4.0	15.9	1.0
	CB	B:PHE306	4.2	13.5	1.0
	CD1	B:PHE306	4.2	14.5	1.0
	CA	B:PHE306	4.3	18.4	1.0
	O	B:LEU304	4.4	19.1	1.0
	CA	B:SER308	4.4	17.6	1.0
	O	B:VAL231	4.4	19.9	1.0
	N	B:VAL309	4.5	15.2	1.0
	CB	B:VAL309	4.5	20.0	1.0
	N	B:PHE306	4.6	18.5	1.0
	CA	B:VAL309	4.6	14.1	1.0
	N	B:PRO307	4.6	18.4	1.0
	N	B:GLY233	4.6	18.3	1.0
	CG	B:PHE306	4.7	16.1	1.0
	C	B:PRO307	4.7	17.1	1.0
	C	B:GLY268	4.8	15.6	1.0
	OE2	B:GLU256	4.8	17.8	1.0
	N	B:GLY232	4.9	15.6	1.0
	CA	B:PRO307	4.9	19.5	1.0
	C	B:VAL231	5.0	17.7	1.0

Reference:

S.Rhee, K.D.Parris, C.C.Hyde, S.A.Ahmed, E.W.Miles, D.R.Davies. Crystal Structures of A Mutant (BETAK87T) Tryptophan Synthase ALPHA2BETA2 Complex with Ligands Bound to the Active Sites of the Alpha- and Beta-Subunits Reveal Ligand-Induced Conformational Changes. Biochemistry V. 36 7664 1997.
ISSN: ISSN 0006-2960
PubMed: 9201907
DOI: 10.1021/BI9700429

Page generated: Mon Oct 7 04:24:13 2024

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