Atomistry » Sodium » PDB 2qd8-2r22 » 2qt9
Atomistry »
  Sodium »
    PDB 2qd8-2r22 »
      2qt9 »

Sodium in PDB 2qt9: Human Dipeptidyl Peptidase IV/CD26 in Complex with A 4-Aryl Cyclohexylalanine Inhibitor

Enzymatic activity of Human Dipeptidyl Peptidase IV/CD26 in Complex with A 4-Aryl Cyclohexylalanine Inhibitor

All present enzymatic activity of Human Dipeptidyl Peptidase IV/CD26 in Complex with A 4-Aryl Cyclohexylalanine Inhibitor:
3.4.14.5;

Protein crystallography data

The structure of Human Dipeptidyl Peptidase IV/CD26 in Complex with A 4-Aryl Cyclohexylalanine Inhibitor, PDB code: 2qt9 was solved by G.Scapin, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.10
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 117.697, 126.072, 136.970, 90.00, 90.00, 90.00
R / Rfree (%) n/a / n/a

Other elements in 2qt9:

The structure of Human Dipeptidyl Peptidase IV/CD26 in Complex with A 4-Aryl Cyclohexylalanine Inhibitor also contains other interesting chemical elements:

Fluorine (F) 2 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Human Dipeptidyl Peptidase IV/CD26 in Complex with A 4-Aryl Cyclohexylalanine Inhibitor (pdb code 2qt9). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Human Dipeptidyl Peptidase IV/CD26 in Complex with A 4-Aryl Cyclohexylalanine Inhibitor, PDB code: 2qt9:

Sodium binding site 1 out of 1 in 2qt9

Go back to Sodium Binding Sites List in 2qt9
Sodium binding site 1 out of 1 in the Human Dipeptidyl Peptidase IV/CD26 in Complex with A 4-Aryl Cyclohexylalanine Inhibitor


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Human Dipeptidyl Peptidase IV/CD26 in Complex with A 4-Aryl Cyclohexylalanine Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na1521

b:24.0
occ:1.00
 O A:GLY490 2.4 20.8 1.0
O A:LEU491 2.4 18.5 1.0
C A:LEU491 3.1 18.5 1.0
C A:GLY490 3.6 20.8 1.0
CA A:LEU491 3.9 18.3 1.0
N A:ARG492 3.9 18.6 1.0
CA A:ARG492 4.1 19.4 1.0
N A:LEU491 4.1 18.6 1.0
CA A:GLY490 4.7 20.1 1.0
CB A:ARG492 5.0 22.3 1.0
O A:HOH1563 5.0 14.9 1.0

Reference:

D.E.Kaelin, A.L.Smenton, G.J.Eiermann, H.He, B.Leiting, K.A.Lyons, R.A.Patel, S.B.Patel, A.Petrov, G.Scapin, J.K.Wu, N.A.Thornberry, A.E.Weber, J.L.Duffy. 4-Arylcyclohexylalanine Analogs As Potent, Selective, and Orally Active Inhibitors of Dipeptidyl Peptidase IV. Bioorg.Med.Chem.Lett. V. 17 5806 2007.
ISSN: ISSN 0960-894X
PubMed: 17851076
DOI: 10.1016/J.BMCL.2007.08.049
Page generated: Mon Oct 7 04:03:52 2024

Last articles

Ca in 5NGQ
Ca in 5NH5
Ca in 5NGY
Ca in 5NG1
Ca in 5NFZ
Ca in 5NF3
Ca in 5NF2
Ca in 5NF0
Ca in 5NEY
Ca in 5NES
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy