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Sodium in PDB 2oph: Human Dipeptidyl Peptidase IV in Complex with An Alpha Amino Acid Inhibitor

Enzymatic activity of Human Dipeptidyl Peptidase IV in Complex with An Alpha Amino Acid Inhibitor

All present enzymatic activity of Human Dipeptidyl Peptidase IV in Complex with An Alpha Amino Acid Inhibitor:
3.4.14.5;

Protein crystallography data

The structure of Human Dipeptidyl Peptidase IV in Complex with An Alpha Amino Acid Inhibitor, PDB code: 2oph was solved by G.Scapin, A.E.Weber, J.L.Duffy, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.40
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 117.912, 126.080, 137.114, 90.00, 90.00, 90.00
R / Rfree (%) n/a / n/a

Other elements in 2oph:

The structure of Human Dipeptidyl Peptidase IV in Complex with An Alpha Amino Acid Inhibitor also contains other interesting chemical elements:

Fluorine (F) 2 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Human Dipeptidyl Peptidase IV in Complex with An Alpha Amino Acid Inhibitor (pdb code 2oph). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Human Dipeptidyl Peptidase IV in Complex with An Alpha Amino Acid Inhibitor, PDB code: 2oph:

Sodium binding site 1 out of 1 in 2oph

Go back to Sodium Binding Sites List in 2oph
Sodium binding site 1 out of 1 in the Human Dipeptidyl Peptidase IV in Complex with An Alpha Amino Acid Inhibitor


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Human Dipeptidyl Peptidase IV in Complex with An Alpha Amino Acid Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na901

b:29.9
occ:1.00
O A:GLY490 2.5 22.8 1.0
O A:LEU491 2.5 19.7 1.0
C A:LEU491 3.2 20.0 1.0
C A:GLY490 3.5 21.7 1.0
CA A:LEU491 3.8 19.6 1.0
N A:ARG492 4.0 19.0 1.0
N A:LEU491 4.1 20.6 1.0
CA A:ARG492 4.2 19.5 1.0
CA A:GLY490 4.7 21.8 1.0
O A:HOH1783 4.9 33.6 1.0

Reference:

J.L.Duffy, B.A.Kirk, L.Wang, G.J.Eiermann, H.He, B.Leiting, K.A.Lyons, R.A.Patel, S.B.Patel, A.Petrov, G.Scapin, J.K.Wu, N.A.Thornberry, A.E.Weber. 4-Aminophenylalanine and 4-Aminocyclohexylalanine Derivatives As Potent, Selective, and Orally Bioavailable Inhibitors of Dipeptidyl Peptidase IV. Bioorg.Med.Chem.Lett. V. 17 2879 2007.
ISSN: ISSN 0960-894X
PubMed: 17350841
DOI: 10.1016/J.BMCL.2007.02.066
Page generated: Tue Dec 15 05:52:44 2020

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