Sodium in PDB 1xxf: Crystal Structure of the Fxia Catalytic Domain in Complex with Ecotin Mutant (Ecotinp)

All present enzymatic activity of Crystal Structure of the Fxia Catalytic Domain in Complex with Ecotin Mutant (Ecotinp):
3.4.21.27;

The structure of Crystal Structure of the Fxia Catalytic Domain in Complex with Ecotin Mutant (Ecotinp), PDB code: 1xxf was solved by L.Jin, P.Pandey, R.E.Babine, J.C.Gorga, K.J.Seidl, E.Gelfand, D.T.Weaver, S.S.Abdel-Meguid, J.E.Strickler, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.75 / 2.60
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	44.512, 90.061, 189.133, 90.00, 90.00, 90.00
R / Rfree (%)	n/a / n/a

The binding sites of Sodium atom in the Crystal Structure of the Fxia Catalytic Domain in Complex with Ecotin Mutant (Ecotinp) (pdb code 1xxf). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Crystal Structure of the Fxia Catalytic Domain in Complex with Ecotin Mutant (Ecotinp), PDB code: 1xxf:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Crystal Structure of the Fxia Catalytic Domain in Complex with Ecotin Mutant (Ecotinp)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of the Fxia Catalytic Domain in Complex with Ecotin Mutant (Ecotinp) within 5.0Å range: probe atom residue distance (Å) B Occ B:Na1001 b:65.4 occ:1.00 OH B:TYR228 2.7 23.9 1.0 OD1 B:ASP189 2.7 37.2 1.0 O B:ALA183 2.7 36.3 1.0 CG2 B:ILE160 3.5 44.5 1.0 CG B:ASP189 3.5 35.8 1.0 C B:ALA183 3.6 36.1 1.0 CZ B:TYR228 3.6 25.8 1.0 CE1 B:TYR228 3.7 26.8 1.0 N B:GLY226 3.8 41.1 1.0 CA B:ASP189 3.9 36.5 1.0 CG1 B:ILE160 4.0 46.6 1.0 CA B:GLY226 4.1 37.4 1.0 CB B:ASP189 4.1 35.8 1.0 CB B:ILE160 4.2 45.6 1.0 CB B:ALA183 4.2 38.6 1.0 CD1 B:ILE160 4.3 47.2 1.0 N B:GLY184 4.3 36.4 1.0 CA B:GLY184 4.3 36.4 1.0 N B:ALA190 4.4 35.0 1.0 CA B:ALA183 4.4 37.7 1.0 OD2 B:ASP189 4.4 33.6 1.0 O B:LYS188A 4.5 37.5 1.0 C B:ASP189 4.7 36.1 1.0 O B:GLY226 4.7 34.8 1.0 N B:ALA183 4.7 39.9 1.0 C B:GLY226 4.8 35.2 1.0 CE2 B:TYR228 4.9 24.2 1.0 N B:ASP189 5.0 36.9 1.0

Sodium binding site 2 out of 2 in the Crystal Structure of the Fxia Catalytic Domain in Complex with Ecotin Mutant (Ecotinp)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of the Fxia Catalytic Domain in Complex with Ecotin Mutant (Ecotinp) within 5.0Å range: probe atom residue distance (Å) B Occ B:Na1002 b:36.5 occ:1.00 OG B:SER198B 2.7 39.6 1.0 O B:TRP137 2.8 35.9 1.0 O B:PRO198 3.1 36.5 1.0 OG1 B:THR139 3.1 34.3 1.0 N B:SER198B 3.4 38.9 1.0 N B:THR139 3.5 36.4 1.0 C B:TRP137 3.6 37.0 1.0 C B:PRO198 3.7 38.3 1.0 CB B:SER198B 3.8 40.0 1.0 CA B:VAL138 3.8 35.1 1.0 CB B:THR139 4.0 33.7 1.0 CG2 B:THR139 4.0 34.7 1.0 N B:VAL138 4.1 35.9 1.0 C B:VAL138 4.1 36.0 1.0 CG B:PRO198 4.1 38.6 1.0 CA B:SER198B 4.2 39.4 1.0 CA B:LEU198A 4.2 39.8 1.0 N B:LEU198A 4.3 39.7 1.0 C B:LEU198A 4.3 40.0 1.0 CB B:PRO198 4.4 37.1 1.0 CA B:THR139 4.4 34.8 1.0 CE3 B:TRP27 4.5 42.6 1.0 CA B:PRO198 4.6 37.4 1.0 CB B:TRP137 4.6 38.1 1.0 CZ3 B:TRP27 4.6 43.6 1.0 CA B:TRP137 4.6 38.0 1.0 CD B:PRO198 4.6 38.8 1.0 NE1 B:TRP29 4.7 27.9 1.0 O B:SER198B 4.8 40.1 1.0

L.Jin, P.Pandey, R.E.Babine, J.C.Gorga, K.J.Seidl, E.Gelfand, D.T.Weaver, S.S.Abdel-Meguid, J.E.Strickler. Crystal Structures of the Fxia Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-Like Interactions J.Biol.Chem. V. 280 4704 2005.
ISSN: ISSN 0021-9258
PubMed: 15545266
DOI: 10.1074/JBC.M411309200