Sodium in PDB 8qzb: D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution)

The structure of D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution), PDB code: 8qzb was solved by P.J.Baker, J.R.Barrett, A.A.A.B.Dakhil, J.Domenech, C.Bisson, N.Pramanpol, J.Ferrer, D.W.Rice, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.63 / 1.16
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	66.182, 74.777, 78.172, 109.07, 107.88, 95.56
R / Rfree (%)	13.5 / 16.5

The structure of D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution) also contains other interesting chemical elements:

Chlorine	(Cl)	4 atoms
Magnesium	(Mg)	19 atoms

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>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Sodium atom in the D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution) (pdb code 8qzb). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 12 binding sites of Sodium where determined in the D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution), PDB code: 8qzb:
Jump to Sodium binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Sodium binding site 1 out of 12 in the D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ A:Na409 b:11.2 occ:1.00 O A:MET215 2.2 10.5 1.0 O A:PHE212 2.3 10.8 1.0 O A:HOH761 2.3 20.9 1.0 O A:ASP243 2.4 10.7 1.0 O A:GLU213 2.7 11.3 1.0 C A:GLU213 3.3 10.9 1.0 C A:MET215 3.3 10.3 1.0 C A:ASP243 3.4 9.9 1.0 C A:PHE212 3.5 9.7 1.0 CA A:GLU213 3.6 10.9 1.0 O A:HOH748 3.8 34.6 1.0 CA A:ASP243 3.9 10.8 1.0 N A:MET215 3.9 9.8 1.0 CB A:ASP243 4.0 11.7 1.0 N A:GLU213 4.0 10.2 1.0 CA A:MET215 4.1 10.0 1.0 C A:ARG216 4.2 9.8 1.0 CG A:GLU217 4.2 20.0 1.0 C A:THR214 4.3 10.1 1.0 N A:THR214 4.3 9.4 1.0 N A:GLU217 4.3 10.9 1.0 O A:ARG216 4.4 9.8 1.0 N A:ARG216 4.4 9.8 1.0 CB A:MET215 4.4 8.8 1.0 CG2 A:ILE244 4.4 11.3 1.0 N A:ILE244 4.5 10.0 1.0 CA A:ARG216 4.6 11.5 1.0 CA A:GLU217 4.7 13.2 1.0 O A:THR214 4.7 11.2 1.0 OE1 A:GLU213 4.7 34.9 1.0 CA A:PHE212 4.7 10.1 1.0 CG A:ASP243 4.7 19.0 1.0 CA A:THR214 4.9 10.4 1.0 OD1 A:ASP243 5.0 24.8 1.0

Sodium binding site 2 out of 12 in the D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ A:Na410 b:22.2 occ:1.00 O A:HOH662 2.0 29.6 1.0 OG1 A:THR132 2.1 11.0 1.0 O A:HOH742 2.1 32.4 1.0 O A:HOH777 2.2 38.3 1.0 O A:ALA134 2.2 10.5 1.0 O A:THR132 2.6 8.9 1.0 O A:HOH844 3.3 23.5 1.0 C A:THR132 3.3 7.8 1.0 CB A:THR132 3.4 9.2 1.0 C A:ALA134 3.4 9.3 1.0 CA A:THR132 3.6 8.1 1.0 N A:THR132 3.7 7.6 1.0 O A:HOH677 3.9 18.3 1.0 N A:ALA134 4.2 8.1 1.0 CG A:GLU136 4.2 10.8 1.0 OE2 A:GLU136 4.3 19.3 1.0 CA A:ALA134 4.3 8.4 1.0 O A:HOH855 4.3 21.5 1.0 C A:LEU133 4.4 7.7 1.0 N A:GLY135 4.4 10.2 1.0 N A:LEU133 4.4 7.2 1.0 CG2 A:THR132 4.4 12.7 1.0 CA A:GLY135 4.6 11.1 1.0 CB A:ALA134 4.6 9.7 1.0 N A:GLU136 4.7 8.9 1.0 O A:LEU133 4.7 8.2 1.0 C A:GLY135 4.8 11.3 1.0 CD A:GLU136 4.8 13.7 1.0 CA A:LEU133 4.9 7.4 1.0

Sodium binding site 3 out of 12 in the D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ A:Na411 b:31.3 occ:1.00 OG1 A:THR88 2.4 17.8 0.5 O A:HOH833 2.4 40.2 1.0 O2A A:NAD401 2.5 15.8 1.0 OG1 A:THR145 2.5 16.2 1.0 CB A:THR145 3.6 11.7 1.0 CB A:THR88 3.7 15.5 0.5 PA A:NAD401 3.7 15.4 1.0 CB A:THR88 3.7 17.1 0.5 N A:GLY89 3.8 11.0 1.0 CG2 A:THR88 3.9 15.7 0.5 N A:THR145 3.9 10.1 1.0 OG1 A:THR88 4.0 20.9 0.5 O1A A:NAD401 4.1 16.7 1.0 CA A:GLY89 4.1 11.9 1.0 O A:HOH643 4.1 38.2 1.0 C A:THR88 4.2 12.7 1.0 O1N A:NAD401 4.2 13.7 1.0 O3 A:NAD401 4.3 14.6 1.0 CA A:THR145 4.3 10.5 1.0 O A:HOH815 4.5 35.2 1.0 CA A:THR88 4.5 13.7 0.5 CA A:THR88 4.5 14.0 0.5 O A:HOH544 4.7 32.9 1.0 CG2 A:THR88 4.7 16.2 0.5 PN A:NAD401 4.7 12.1 1.0 CG2 A:THR145 4.8 11.7 1.0 O A:THR88 4.8 15.1 1.0 C A:GLY144 4.9 10.7 1.0 O5B A:NAD401 4.9 15.5 1.0

Sodium binding site 4 out of 12 in the D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ B:Na410 b:11.6 occ:1.00 O B:MET215 2.2 10.9 1.0 O B:PHE212 2.3 12.1 1.0 O B:ASP243 2.3 10.6 1.0 O B:HOH810 2.3 21.9 1.0 O B:HOH805 2.6 43.5 1.0 O B:GLU213 2.8 12.4 1.0 C B:GLU213 3.4 10.4 1.0 C B:ASP243 3.4 9.7 1.0 C B:MET215 3.4 10.1 1.0 C B:PHE212 3.5 9.5 1.0 CA B:GLU213 3.6 10.3 1.0 CA B:ASP243 3.8 10.7 1.0 O B:HOH765 3.9 31.6 1.0 N B:MET215 3.9 9.4 1.0 CB B:ASP243 4.0 13.6 1.0 N B:GLU213 4.0 9.7 1.0 CA B:MET215 4.1 9.7 1.0 C B:ARG216 4.2 10.4 1.0 C B:THR214 4.3 10.3 1.0 CG B:GLU217 4.3 24.8 1.0 N B:GLU217 4.3 11.4 1.0 N B:THR214 4.3 9.6 1.0 CB B:MET215 4.4 9.7 1.0 O B:ARG216 4.4 10.1 1.0 N B:ARG216 4.4 10.2 1.0 CG2 B:ILE244 4.5 11.2 1.0 N B:ILE244 4.5 10.0 1.0 CA B:GLU217 4.6 12.2 1.0 CA B:ARG216 4.7 10.8 1.0 O B:THR214 4.7 11.3 1.0 CA B:PHE212 4.7 9.9 1.0 CG B:ASP243 4.7 21.2 1.0 OE1 B:GLU213 4.8 38.4 1.0 CA B:THR214 4.9 10.2 1.0 OD1 B:ASP243 4.9 26.9 1.0 CD B:GLU213 4.9 28.4 1.0

Sodium binding site 5 out of 12 in the D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 5 of D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ B:Na411 b:29.1 occ:1.00 O B:HOH570 1.8 15.5 1.0 O B:HOH707 2.1 28.3 1.0 OG1 B:THR132 2.2 10.9 1.0 O B:ALA134 2.3 10.1 1.0 O B:THR132 2.6 8.8 1.0 O B:HOH880 3.1 16.2 1.0 C B:THR132 3.4 7.6 1.0 CB B:THR132 3.5 8.8 1.0 C B:ALA134 3.5 8.6 1.0 CA B:THR132 3.7 7.5 1.0 N B:THR132 3.7 8.1 1.0 OE2 B:GLU136 4.0 15.8 1.0 CG B:GLU136 4.0 10.7 1.0 O B:HOH711 4.1 19.9 1.0 O B:HOH893 4.2 16.4 1.0 N B:ALA134 4.3 7.5 1.0 O B:HOH933 4.3 57.8 1.0 C B:LEU133 4.4 7.9 1.0 N B:GLY135 4.4 8.6 1.0 CA B:ALA134 4.4 8.5 1.0 CA B:GLY135 4.5 10.3 1.0 CG2 B:THR132 4.5 11.8 1.0 N B:LEU133 4.5 7.7 1.0 CD B:GLU136 4.5 12.3 1.0 N B:GLU136 4.6 9.0 1.0 C B:GLY135 4.7 9.7 1.0 O B:LEU133 4.7 8.1 1.0 CB B:ALA134 4.8 10.0 1.0 O B:HOH622 4.9 36.1 1.0 CA B:LEU133 4.9 8.3 1.0 O A:HOH626 4.9 10.7 1.0

Sodium binding site 6 out of 12 in the D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 6 of D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ B:Na412 b:21.6 occ:1.00 O B:HOH878 2.3 43.5 1.0 OG1 B:THR88 2.4 11.4 0.5 OG1 B:THR145 2.5 12.7 1.0 O2A B:NAD401 2.6 10.9 1.0 O B:HOH753 3.0 37.3 1.0 O B:HOH691 3.4 39.7 1.0 CB B:THR145 3.6 10.5 1.0 CB B:THR88 3.6 10.4 0.5 CB B:THR88 3.6 10.6 0.5 CG2 B:THR88 3.7 10.4 0.5 PA B:NAD401 3.8 10.1 1.0 N B:GLY89 3.8 8.9 1.0 N B:THR145 3.9 7.9 1.0 O1N B:NAD401 4.0 9.1 1.0 OG1 B:THR88 4.0 14.6 0.5 CA B:GLY89 4.1 8.4 1.0 C B:THR88 4.2 9.0 1.0 O1A B:NAD401 4.2 11.1 1.0 CA B:THR145 4.3 8.7 1.0 O3 B:NAD401 4.4 10.1 1.0 CA B:THR88 4.4 9.3 0.5 CA B:THR88 4.5 9.5 0.5 CG2 B:THR88 4.5 10.8 0.5 O B:HOH672 4.5 26.3 1.0 O B:HOH840 4.5 34.1 1.0 PN B:NAD401 4.6 8.7 1.0 O B:HOH519 4.8 34.6 1.0 CG2 B:THR145 4.8 10.0 1.0 O B:THR88 4.8 11.4 1.0 O B:HOH701 4.9 9.3 1.0 C B:GLY144 5.0 7.8 1.0

Sodium binding site 7 out of 12 in the D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 7 of D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ C:Na410 b:11.7 occ:1.00 O C:MET215 2.2 11.5 1.0 O C:HOH801 2.3 21.7 1.0 O C:PHE212 2.3 10.8 1.0 O C:ASP243 2.4 10.4 1.0 O C:GLU213 2.7 12.3 1.0 C C:GLU213 3.3 10.2 1.0 C C:MET215 3.4 10.4 1.0 C C:ASP243 3.4 10.0 1.0 C C:PHE212 3.5 10.1 1.0 CA C:GLU213 3.6 10.6 1.0 CA C:ASP243 3.8 11.3 1.0 O C:HOH751 3.8 34.4 1.0 N C:MET215 3.9 9.6 1.0 CB C:ASP243 3.9 12.5 1.0 N C:GLU213 4.0 10.6 1.0 CA C:MET215 4.1 10.1 1.0 CG C:GLU217 4.2 22.2 1.0 C C:ARG216 4.2 9.8 1.0 C C:THR214 4.3 9.3 1.0 N C:THR214 4.3 9.7 1.0 N C:GLU217 4.4 11.2 1.0 O C:ARG216 4.4 10.3 1.0 CB C:MET215 4.4 8.9 1.0 N C:ARG216 4.4 9.8 1.0 CG2 C:ILE244 4.4 10.6 1.0 N C:ILE244 4.5 10.2 1.0 CA C:ARG216 4.7 11.0 1.0 O C:THR214 4.7 12.2 1.0 CA C:GLU217 4.7 13.2 1.0 CG C:ASP243 4.7 21.9 1.0 CA C:PHE212 4.7 9.8 1.0 CA C:THR214 4.8 10.7 1.0 OD1 C:ASP243 4.9 24.8 1.0 OE2 C:GLU217 4.9 44.5 1.0 OE1 C:GLU213 4.9 45.2 1.0

Sodium binding site 8 out of 12 in the D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 8 of D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ C:Na411 b:20.5 occ:1.00 O C:HOH538 2.0 11.8 0.5 OG1 C:THR132 2.2 11.3 1.0 O C:HOH748 2.2 30.2 1.0 O C:ALA134 2.2 11.0 1.0 O C:HOH781 2.3 35.2 1.0 O C:HOH538 2.4 15.6 0.5 O C:THR132 2.5 9.5 1.0 C C:THR132 3.3 8.1 1.0 CB C:THR132 3.4 9.7 1.0 C C:ALA134 3.5 9.3 1.0 CA C:THR132 3.6 8.8 1.0 N C:THR132 3.7 8.1 1.0 O C:HOH673 4.0 18.5 1.0 N C:ALA134 4.2 7.9 1.0 CG C:GLU136 4.2 10.6 1.0 OE2 C:GLU136 4.2 22.8 1.0 CA C:ALA134 4.3 8.7 1.0 O C:HOH504 4.3 28.6 1.0 C C:LEU133 4.3 8.3 1.0 N C:LEU133 4.4 8.1 1.0 O C:HOH876 4.4 24.6 1.0 N C:GLY135 4.4 10.1 1.0 CG2 C:THR132 4.5 13.4 1.0 CA C:GLY135 4.6 10.7 1.0 CB C:ALA134 4.7 8.9 1.0 N C:GLU136 4.7 9.5 1.0 O C:LEU133 4.7 8.3 1.0 CD C:GLU136 4.8 13.7 1.0 C C:GLY135 4.8 11.6 1.0 CA C:LEU133 4.8 8.3 1.0 C C:PHE131 5.0 7.0 1.0

Sodium binding site 9 out of 12 in the D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 9 of D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ C:Na412 b:23.7 occ:1.00 O C:HOH837 2.3 55.0 1.0 OG1 C:THR88 2.5 11.4 0.5 O2A C:NAD401 2.5 12.7 1.0 OG1 C:THR145 2.6 13.3 1.0 O C:HOH565 3.0 48.2 1.0 O C:HOH596 3.5 39.3 1.0 CB C:THR145 3.6 9.9 1.0 CB C:THR88 3.7 12.7 0.5 CB C:THR88 3.7 10.9 0.5 PA C:NAD401 3.7 12.0 1.0 CG2 C:THR88 3.8 12.8 0.5 N C:THR145 3.9 8.6 1.0 N C:GLY89 3.9 9.6 1.0 OG1 C:THR88 4.0 16.9 0.5 O1N C:NAD401 4.0 11.4 1.0 O1A C:NAD401 4.2 13.6 1.0 C C:THR88 4.2 11.6 1.0 CA C:GLY89 4.3 9.3 1.0 O3 C:NAD401 4.3 11.8 1.0 CA C:THR145 4.3 8.9 1.0 O C:HOH644 4.5 29.6 1.0 CA C:THR88 4.5 10.2 0.5 CA C:THR88 4.5 10.9 0.5 CG2 C:THR88 4.6 14.8 0.5 PN C:NAD401 4.6 10.2 1.0 O C:HOH816 4.6 39.6 1.0 CG2 C:THR145 4.8 10.4 1.0 O C:THR88 4.8 12.7 1.0 O C:HOH558 4.9 35.4 1.0 C C:GLY144 4.9 7.8 1.0 O C:HOH664 5.0 10.0 1.0 O5B C:NAD401 5.0 12.6 1.0

Sodium binding site 10 out of 12 in the D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 10 of D-2-Hydroxyacid Dehydrogenase (D2HDH) From Haloferax Mediterranei in Complex with 2-Ketohexanoic Acid, Nad+ and Chloride (1.16 A Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ D:Na406 b:13.2 occ:1.00 O D:MET215 2.2 13.1 1.0 O D:PHE212 2.3 12.2 1.0 O D:HOH756 2.3 21.9 1.0 O D:ASP243 2.4 12.0 1.0 O D:HOH745 2.7 46.9 1.0 O D:GLU213 2.7 13.3 1.0 C D:GLU213 3.3 11.6 1.0 C D:MET215 3.3 10.9 1.0 C D:ASP243 3.4 13.4 1.0 C D:PHE212 3.5 12.2 1.0 CA D:GLU213 3.7 13.7 1.0 O D:HOH702 3.8 30.1 1.0 CA D:ASP243 3.9 13.1 1.0 N D:MET215 3.9 11.2 1.0 CB D:ASP243 4.0 14.6 1.0 N D:GLU213 4.0 12.8 1.0 CA D:MET215 4.0 10.5 1.0 C D:ARG216 4.2 11.1 1.0 CG D:GLU217 4.2 23.6 1.0 C D:THR214 4.3 11.4 1.0 N D:GLU217 4.3 12.5 1.0 N D:THR214 4.3 10.8 1.0 N D:ARG216 4.4 12.3 1.0 O D:ARG216 4.4 10.7 1.0 CB D:MET215 4.4 11.7 1.0 CG2 D:ILE244 4.5 12.3 1.0 N D:ILE244 4.5 11.2 1.0 CA D:ARG216 4.6 12.0 1.0 CA D:GLU217 4.6 14.3 1.0 CA D:PHE212 4.7 10.9 1.0 O D:THR214 4.7 12.3 1.0 CG D:ASP243 4.7 18.4 1.0 CA D:THR214 4.9 10.9 1.0 OD1 D:ASP243 4.9 24.2 1.0 CD D:GLU213 5.0 29.8 1.0

J.Domenech, N.Pramanpol, C.Bisson, S.E.Sedelnikova, J.R.Barrett, A.A.A.B.Dakhil, A.S.Abdelhameed, S.E.Harding, D.W.Rice, P.J.Baker, J.Ferrer. Ternary Complexes of Haloferax Mediterranei D-2-Hydroxyacid Dehydrogenase Provide Insights Into Halophilicity and the Chiral Specificity of Its Reaction Mechanism. To Be Published.