Sodium in PDB 8fhq: Cryo-Em Structure of Human Ncc (Class 3-2)

The structure of Cryo-Em Structure of Human Ncc (Class 3-2) also contains other interesting chemical elements:

Chlorine	(Cl)	2 atoms
Fluorine	(F)	6 atoms

The binding sites of Sodium atom in the Cryo-Em Structure of Human Ncc (Class 3-2) (pdb code 8fhq). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Cryo-Em Structure of Human Ncc (Class 3-2), PDB code: 8fhq:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Cryo-Em Structure of Human Ncc (Class 3-2)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryo-Em Structure of Human Ncc (Class 3-2) within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1102 b:31.2 occ:1.00 O A:LEU148 2.3 33.6 1.0 O A:ALA464 2.3 35.8 1.0 O A:TRP151 2.4 33.2 1.0 OG A:SER468 2.4 33.8 1.0 OG A:SER467 2.6 34.8 1.0 C A:ALA464 3.3 35.8 1.0 N A:SER468 3.5 33.8 1.0 C A:LEU148 3.5 33.6 1.0 C A:TRP151 3.6 33.2 1.0 CB A:SER468 3.6 33.8 1.0 CA A:ALA464 3.6 35.8 1.0 CB A:SER467 3.8 34.8 1.0 CA A:SER468 4.0 33.8 1.0 C A:SER467 4.2 34.8 1.0 CA A:LEU148 4.3 33.6 1.0 CB A:ALA464 4.3 35.8 1.0 N A:ASN149 4.4 33.6 1.0 O A:GLY463 4.4 38.1 1.0 CA A:SER467 4.5 34.8 1.0 N A:GLY152 4.5 36.8 1.0 N A:THR465 4.5 35.9 1.0 CA A:TRP151 4.5 33.2 1.0 CA A:GLY152 4.5 36.8 1.0 CA A:ASN149 4.5 33.6 1.0 CB A:TRP151 4.6 33.2 1.0 N A:TRP151 4.7 33.2 1.0 CB A:LEU148 4.7 33.6 1.0 N A:SER467 4.7 34.8 1.0 N A:ALA464 4.8 35.8 1.0 C A:ASN149 4.8 33.6 1.0 CA A:THR465 4.9 35.9 1.0 O A:ASN149 4.9 33.6 1.0

Sodium binding site 2 out of 2 in the Cryo-Em Structure of Human Ncc (Class 3-2)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Cryo-Em Structure of Human Ncc (Class 3-2) within 5.0Å range: probe atom residue distance (Å) B Occ B:Na1102 b:30.5 occ:1.00 O B:LEU148 2.3 33.0 1.0 O B:ALA464 2.3 35.9 1.0 O B:TRP151 2.4 33.0 1.0 OG B:SER468 2.4 33.7 1.0 OG B:SER467 2.6 34.5 1.0 C B:ALA464 3.3 35.9 1.0 N B:SER468 3.5 33.7 1.0 C B:LEU148 3.5 33.0 1.0 C B:TRP151 3.6 33.0 1.0 CB B:SER468 3.6 33.7 1.0 CA B:ALA464 3.6 35.9 1.0 CB B:SER467 3.8 34.5 1.0 CA B:SER468 4.0 33.7 1.0 C B:SER467 4.2 34.5 1.0 CA B:LEU148 4.3 33.0 1.0 CB B:ALA464 4.3 35.9 1.0 O B:GLY463 4.4 38.1 1.0 N B:ASN149 4.4 33.3 1.0 CA B:SER467 4.5 34.5 1.0 N B:GLY152 4.5 36.0 1.0 N B:THR465 4.5 36.0 1.0 CA B:TRP151 4.5 33.0 1.0 CA B:GLY152 4.5 36.0 1.0 CA B:ASN149 4.6 33.3 1.0 CB B:TRP151 4.6 33.0 1.0 N B:TRP151 4.7 33.0 1.0 CB B:LEU148 4.7 33.0 1.0 N B:SER467 4.7 34.5 1.0 N B:ALA464 4.8 35.9 1.0 C B:ASN149 4.8 33.3 1.0 O B:ASN149 4.9 33.3 1.0 CA B:THR465 4.9 36.0 1.0

M.Fan, J.Zhang, C.Lee, J.Zhang, L.Feng. Structure and Thiazide Inhibition Mechanism of the Human Na-Cl Cotransporter Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-023-05718-0