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Sodium in PDB 8fho: Cryo-Em Structure of Human Ncc (Class 1)

Other elements in 8fho:

The structure of Cryo-Em Structure of Human Ncc (Class 1) also contains other interesting chemical elements:

Fluorine (F) 6 atoms
Chlorine (Cl) 2 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Cryo-Em Structure of Human Ncc (Class 1) (pdb code 8fho). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Cryo-Em Structure of Human Ncc (Class 1), PDB code: 8fho:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in 8fho

Go back to Sodium Binding Sites List in 8fho
Sodium binding site 1 out of 2 in the Cryo-Em Structure of Human Ncc (Class 1)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Cryo-Em Structure of Human Ncc (Class 1) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na1103

b:29.0
occ:1.00
OG A:SER468 2.3 27.1 1.0
O A:ALA464 2.3 28.3 1.0
O A:LEU148 2.4 29.6 1.0
O A:TRP151 2.5 27.3 1.0
OG A:SER467 3.0 27.3 1.0
C A:ALA464 3.2 28.3 1.0
CB A:SER468 3.4 27.1 1.0
N A:SER468 3.5 27.1 1.0
C A:LEU148 3.6 29.6 1.0
CA A:ALA464 3.7 28.3 1.0
C A:TRP151 3.7 27.3 1.0
CA A:SER468 3.9 27.1 1.0
CB A:SER467 4.2 27.3 1.0
O A:ASN149 4.2 38.7 1.0
N A:THR465 4.3 27.3 1.0
CA A:ASN149 4.4 38.7 1.0
C A:SER467 4.4 27.3 1.0
CB A:ALA464 4.4 28.3 1.0
N A:ASN149 4.4 38.7 1.0
C A:ASN149 4.4 38.7 1.0
O A:GLY463 4.5 28.9 1.0
CA A:LEU148 4.5 29.6 1.0
N A:GLY152 4.6 29.0 1.0
CA A:GLY152 4.6 29.0 1.0
CA A:TRP151 4.6 27.3 1.0
N A:TRP151 4.7 27.3 1.0
CA A:SER467 4.7 27.3 1.0
CB A:TRP151 4.8 27.3 1.0
CA A:THR465 4.8 27.3 1.0
N A:SER467 4.9 27.3 1.0
N A:ALA464 4.9 28.3 1.0
CB A:LEU148 5.0 29.6 1.0

Sodium binding site 2 out of 2 in 8fho

Go back to Sodium Binding Sites List in 8fho
Sodium binding site 2 out of 2 in the Cryo-Em Structure of Human Ncc (Class 1)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Cryo-Em Structure of Human Ncc (Class 1) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Na1103

b:46.0
occ:1.00
O B:ALA464 2.3 51.0 1.0
O B:LEU148 2.4 46.2 1.0
OG B:SER468 2.5 46.0 1.0
OG B:SER467 2.5 47.7 1.0
O B:TRP151 2.6 44.3 1.0
N B:SER468 3.1 46.0 1.0
CB B:SER468 3.3 46.0 1.0
C B:ALA464 3.3 51.0 1.0
C B:LEU148 3.6 46.2 1.0
CA B:SER468 3.6 46.0 1.0
C B:TRP151 3.7 44.3 1.0
CA B:ALA464 3.8 51.0 1.0
CB B:SER467 3.8 47.7 1.0
C B:SER467 4.0 47.7 1.0
CB B:TRP151 4.2 44.3 1.0
CA B:SER467 4.4 47.7 1.0
CA B:LEU148 4.4 46.2 1.0
N B:THR465 4.4 49.9 1.0
CA B:TRP151 4.4 44.3 1.0
CB B:ALA464 4.5 51.0 1.0
O B:GLY463 4.5 50.4 1.0
N B:ASN149 4.6 44.2 1.0
N B:SER467 4.6 47.7 1.0
O B:ASN149 4.6 44.2 1.0
CA B:ASN149 4.6 44.2 1.0
N B:GLY152 4.7 45.8 1.0
N B:TRP151 4.7 44.3 1.0
C B:ASN149 4.7 44.2 1.0
CA B:THR465 4.7 49.9 1.0
CB B:LEU148 4.8 46.2 1.0
CA B:GLY152 4.8 45.8 1.0
CD1 B:LEU148 4.9 46.2 1.0
O B:SER467 4.9 47.7 1.0
C B:THR465 4.9 49.9 1.0
O B:THR465 4.9 49.9 1.0

Reference:

M.Fan, J.Zhang, C.Lee, J.Zhang, L.Feng. Structure and Thiazide Inhibition Mechanism of the Human Na-Cl Cotransporter Nature 2023.
ISSN: ESSN 1476-4687
DOI: 10.1038/S41586-023-05718-0
Page generated: Mon Aug 18 14:10:02 2025

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