Sodium in PDB 8cpr: G13D Mutant of KRAS4B (2-169) Bound to Gdp with the Switch-I in Fully Open Conformation Crystallized in Sodium Potassium Phosphate Buffer

The structure of G13D Mutant of KRAS4B (2-169) Bound to Gdp with the Switch-I in Fully Open Conformation Crystallized in Sodium Potassium Phosphate Buffer, PDB code: 8cpr was solved by M.Moche, O.Jungholm, E.Strandback, H.Ampah-Korsah, T.Nyman, O.Orwar, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.72 / 2.00
Space group	P 3 2 1
Cell size a, b, c (Å), α, β, γ (°)	76.413, 76.413, 55.862, 90, 90, 120
R / Rfree (%)	17.9 / 24.8

The binding sites of Sodium atom in the G13D Mutant of KRAS4B (2-169) Bound to Gdp with the Switch-I in Fully Open Conformation Crystallized in Sodium Potassium Phosphate Buffer (pdb code 8cpr). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the G13D Mutant of KRAS4B (2-169) Bound to Gdp with the Switch-I in Fully Open Conformation Crystallized in Sodium Potassium Phosphate Buffer, PDB code: 8cpr:

Sodium binding site 1 out of 1 in the G13D Mutant of KRAS4B (2-169) Bound to Gdp with the Switch-I in Fully Open Conformation Crystallized in Sodium Potassium Phosphate Buffer


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of G13D Mutant of KRAS4B (2-169) Bound to Gdp with the Switch-I in Fully Open Conformation Crystallized in Sodium Potassium Phosphate Buffer within 5.0Å range: probe atom residue distance (Å) B Occ A:Na202 b:76.6 occ:1.00 OE2 A:GLU63 2.7 54.2 1.0 O A:GLY60 2.8 52.0 1.0 CB A:GLU63 3.2 40.9 1.0 O A:ALA59 3.3 82.5 1.0 C A:GLY60 3.5 63.9 1.0 CA A:GLY60 3.5 63.6 1.0 CD A:GLU63 3.7 50.3 1.0 CG A:GLU63 4.0 43.9 1.0 C A:ALA59 4.0 68.7 1.0 N A:GLY60 4.2 61.9 1.0 CE2 A:TYR64 4.3 31.1 1.0 CA A:GLU63 4.4 41.5 1.0 N A:GLU63 4.5 38.1 1.0 CD2 A:TYR64 4.6 28.4 1.0 N A:GLN61 4.7 61.0 1.0 OE1 A:GLU63 4.8 48.6 1.0

M.Moche, O.Jungholm, E.Strandback, T.Nyman, O.Orwar, H.Ampah-Korsah. A G13D Open-State-Selective Anti-Kras Antibody Shows in Vivo Anti-Cancer Activity To Be Published.