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Sodium in PDB 7zkl: X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha

Enzymatic activity of X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha

All present enzymatic activity of X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha:
3.4.21.5;

Protein crystallography data

The structure of X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha, PDB code: 7zkl was solved by R.Troisi, F.Sica, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 76.57 / 3.18
Space group P 64
Cell size a, b, c (Å), α, β, γ (°) 152.91, 152.91, 79.49, 90, 90, 120
R / Rfree (%) 19.1 / 23.1

Other elements in 7zkl:

The structure of X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha also contains other interesting chemical elements:

Potassium (K) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha (pdb code 7zkl). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha, PDB code: 7zkl:

Sodium binding site 1 out of 1 in 7zkl

Go back to Sodium Binding Sites List in 7zkl
Sodium binding site 1 out of 1 in the X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of X-Ray Structure of the Complex Between Human Alpha Thrombin and A Pseudo-Cyclic Thrombin Binding Aptamer (Tba-Nnp/Ddp) - Crystal Form Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
H:Na302

b:106.2
occ:1.00
O H:LYS224 2.5 111.8 1.0
O H:ARG221 3.3 109.1 1.0
C H:LYS224 3.7 114.8 1.0
O H:TYR184A 3.8 119.0 1.0
C H:ARG221 3.9 113.8 1.0
N H:ARG221 3.9 121.6 1.0
CD1 H:TYR225 4.1 141.6 1.0
CA H:ASP221A 4.2 116.6 1.0
C H:ASP221A 4.3 117.8 1.0
CE1 H:TYR225 4.4 139.8 1.0
N H:LYS224 4.4 110.8 1.0
OD1 H:ASP221A 4.6 126.5 1.0
CA H:ARG221 4.6 118.2 1.0
N H:ASP222 4.6 106.1 1.0
CA H:LYS224 4.6 113.8 1.0
N H:TYR225 4.7 114.9 1.0
CA H:ASP222 4.7 105.4 1.0
CA H:TYR225 4.7 113.3 1.0
N H:GLY223 4.8 94.1 1.0
O H:GLY188 4.9 99.2 1.0
N H:TYR184A 4.9 101.4 1.0
N H:ASP221A 5.0 113.9 1.0
C H:TYR184A 5.0 110.8 1.0

Reference:

R.Troisi, C.Riccardi, K.Perez De Carvasal, M.Smietana, F.Morvan, P.Del Vecchio, D.Montesarchio, F.Sica. A Terminal Functionalization Strategy Reveals Unusual Binding Abilities of Anti-Thrombin Anticoagulant Aptamers. Mol Ther Nucleic Acids V. 30 585 2022.
ISSN: ISSN 2162-2531
PubMed: 36457701
DOI: 10.1016/J.OMTN.2022.11.007
Page generated: Mon Aug 18 12:51:55 2025

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