Sodium in PDB 6sxc: Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with 4-Hydroxytamoxifen (2.5 Angstrom Resolution)

The structure of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with 4-Hydroxytamoxifen (2.5 Angstrom Resolution), PDB code: 6sxc was solved by A.Sula, D.Hollingworth, B.A.Wallace, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.41 / 2.50
Space group	I 4 2 2
Cell size a, b, c (Å), α, β, γ (°)	109.125, 109.125, 210.596, 90, 90, 90
R / Rfree (%)	23 / 24.7

The binding sites of Sodium atom in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with 4-Hydroxytamoxifen (2.5 Angstrom Resolution) (pdb code 6sxc). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 3 binding sites of Sodium where determined in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with 4-Hydroxytamoxifen (2.5 Angstrom Resolution), PDB code: 6sxc:
Jump to Sodium binding site number: 1; 2; 3;

Sodium binding site 1 out of 3 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with 4-Hydroxytamoxifen (2.5 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with 4-Hydroxytamoxifen (2.5 Angstrom Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ A:Na301 b:86.5 occ:0.25 NA A:NA302 3.4 101.0 0.2 O A:THR176 4.7 47.0 1.0 CD1 A:LEU177 5.0 37.3 1.0 CB A:LEU177 5.0 38.5 1.0

Sodium binding site 2 out of 3 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with 4-Hydroxytamoxifen (2.5 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with 4-Hydroxytamoxifen (2.5 Angstrom Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ A:Na302 b:101.0 occ:0.25 NA A:NA303 3.1 129.4 0.2 NA A:NA301 3.4 86.5 0.2 O A:LEU177 4.2 43.4 1.0 C A:LEU177 4.9 43.1 1.0 CA A:GLU178 5.0 38.5 1.0

Sodium binding site 3 out of 3 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with 4-Hydroxytamoxifen (2.5 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with 4-Hydroxytamoxifen (2.5 Angstrom Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ A:Na303 b:129.4 occ:0.25 NA A:NA302 3.1 101.0 0.2 OE2 A:GLU178 4.5 53.1 1.0 N A:SER179 4.5 41.9 1.0 OG A:SER179 4.6 51.7 1.0

A.Sula, D.Hollingworth, L.C.Ng, M.Larmore, P.G.Decaen, B.A.Wallace. A Tamoxifen Receptor Within A Voltage-Gated Sodium Channel Mol.Cell 2021.
ISSN: ISSN 1097-2765
DOI: 10.1016/J.MOLCEL.2020.12.048