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Atomistry » Sodium » PDB 6awz-6bfo » 6ay3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Sodium » PDB 6awz-6bfo » 6ay3 » |
Sodium in PDB 6ay3: Crebbp Bromodomain in Complex with CPD16 (5-(7-(Difluoromethyl)-6-(1- Methyl-1H-Pyrazol-4-Yl)-3,4-Dihydroquinolin-1(2H)-Yl)-N-Methyl-1H- Indole-3-Carboxamide)Enzymatic activity of Crebbp Bromodomain in Complex with CPD16 (5-(7-(Difluoromethyl)-6-(1- Methyl-1H-Pyrazol-4-Yl)-3,4-Dihydroquinolin-1(2H)-Yl)-N-Methyl-1H- Indole-3-Carboxamide)
All present enzymatic activity of Crebbp Bromodomain in Complex with CPD16 (5-(7-(Difluoromethyl)-6-(1- Methyl-1H-Pyrazol-4-Yl)-3,4-Dihydroquinolin-1(2H)-Yl)-N-Methyl-1H- Indole-3-Carboxamide):
2.3.1.48; Protein crystallography data
The structure of Crebbp Bromodomain in Complex with CPD16 (5-(7-(Difluoromethyl)-6-(1- Methyl-1H-Pyrazol-4-Yl)-3,4-Dihydroquinolin-1(2H)-Yl)-N-Methyl-1H- Indole-3-Carboxamide), PDB code: 6ay3
was solved by
J.M.Murray,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6ay3:
The structure of Crebbp Bromodomain in Complex with CPD16 (5-(7-(Difluoromethyl)-6-(1- Methyl-1H-Pyrazol-4-Yl)-3,4-Dihydroquinolin-1(2H)-Yl)-N-Methyl-1H- Indole-3-Carboxamide) also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the Crebbp Bromodomain in Complex with CPD16 (5-(7-(Difluoromethyl)-6-(1- Methyl-1H-Pyrazol-4-Yl)-3,4-Dihydroquinolin-1(2H)-Yl)-N-Methyl-1H- Indole-3-Carboxamide)
(pdb code 6ay3). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crebbp Bromodomain in Complex with CPD16 (5-(7-(Difluoromethyl)-6-(1- Methyl-1H-Pyrazol-4-Yl)-3,4-Dihydroquinolin-1(2H)-Yl)-N-Methyl-1H- Indole-3-Carboxamide), PDB code: 6ay3: Sodium binding site 1 out of 1 in 6ay3Go back to![]() ![]()
Sodium binding site 1 out
of 1 in the Crebbp Bromodomain in Complex with CPD16 (5-(7-(Difluoromethyl)-6-(1- Methyl-1H-Pyrazol-4-Yl)-3,4-Dihydroquinolin-1(2H)-Yl)-N-Methyl-1H- Indole-3-Carboxamide)
![]() Mono view ![]() Stereo pair view
Reference:
S.M.Bronner,
J.Murray,
F.A.Romero,
K.W.Lai,
V.Tsui,
P.Cyr,
M.H.Beresini,
G.De Leon Boenig,
Z.Chen,
E.F.Choo,
K.R.Clark,
T.D.Crawford,
H.Jayaram,
S.Kaufman,
R.Li,
Y.Li,
J.Liao,
X.Liang,
W.Liu,
J.Ly,
J.Maher,
J.Wai,
F.Wang,
A.Zheng,
X.Zhu,
S.Magnuson.
A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (Cbp) Inhibitors. J. Med. Chem. V. 60 10151 2017.
Page generated: Mon Aug 18 03:42:09 2025
ISSN: ISSN 1520-4804 PubMed: 29155580 DOI: 10.1021/ACS.JMEDCHEM.7B01372 |
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