Sodium in PDB 5uih: Structure of Dhfr with Bound Phenformin and Nadp

All present enzymatic activity of Structure of Dhfr with Bound Phenformin and Nadp:
1.5.1.3;

The structure of Structure of Dhfr with Bound Phenformin and Nadp, PDB code: 5uih was solved by L.C.Pedersen, R.E.London, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	23.34 / 1.65
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	38.605, 58.872, 40.145, 90.00, 107.45, 90.00
R / Rfree (%)	17.8 / 21.6

The binding sites of Sodium atom in the Structure of Dhfr with Bound Phenformin and Nadp (pdb code 5uih). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Structure of Dhfr with Bound Phenformin and Nadp, PDB code: 5uih:

Sodium binding site 1 out of 1 in the Structure of Dhfr with Bound Phenformin and Nadp


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Structure of Dhfr with Bound Phenformin and Nadp within 5.0Å range: probe atom residue distance (Å) B Occ A:Na202 b:18.6 occ:1.00 O A:HOH397 2.4 19.6 1.0 O A:HOH361 2.5 22.3 1.0 O A:HOH302 3.9 26.7 1.0 O A:HOH481 4.1 30.9 1.0 NZ A:LYS38 4.1 15.2 1.0 OH A:TYR111 4.1 17.1 1.0 O A:HOH334 4.1 21.6 1.0 OE1 A:GLU90 4.4 17.3 1.0 O A:HOH399 4.6 19.7 1.0 OD1 A:ASN34 4.7 15.4 1.0 O A:HOH495 4.9 31.3 1.0 O A:HOH342 5.0 24.8 1.0 NZ A:LYS109 5.0 36.0 1.0

S.A.Gabel, M.R.Duff, L.C.Pedersen, E.F.Derose, J.M.Krahn, E.E.Howell, R.E.London. A Structural Basis For Biguanide Activity. Biochemistry V. 56 4786 2017.
ISSN: ISSN 1520-4995
PubMed: 28766937
DOI: 10.1021/ACS.BIOCHEM.7B00619