|
Atomistry » Sodium » PDB 5kd8-5kw9 » 5kh9 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Sodium » PDB 5kd8-5kw9 » 5kh9 » |
Sodium in PDB 5kh9: Crystal Structure of A Low Occupancy Fragment Candidate (5-[(4- Isopropylphenyl)Amino]-6-Methyl-1,2,4-Triazin-3(2H)-One) Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger DomainEnzymatic activity of Crystal Structure of A Low Occupancy Fragment Candidate (5-[(4- Isopropylphenyl)Amino]-6-Methyl-1,2,4-Triazin-3(2H)-One) Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain
All present enzymatic activity of Crystal Structure of A Low Occupancy Fragment Candidate (5-[(4- Isopropylphenyl)Amino]-6-Methyl-1,2,4-Triazin-3(2H)-One) Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain:
3.5.1.98; Protein crystallography data
The structure of Crystal Structure of A Low Occupancy Fragment Candidate (5-[(4- Isopropylphenyl)Amino]-6-Methyl-1,2,4-Triazin-3(2H)-One) Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain, PDB code: 5kh9
was solved by
R.J.Harding,
W.Tempel,
M.Ravichandran,
P.Collins,
N.Pearce,
J.Brandao-Neto,
A.Douangamath,
M.Schapira,
C.Bountra,
A.M.Edwards,
F.Von Delft,
V.Santhakumar,
C.M.Arrowsmith,
Structural Genomics Consortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5kh9:
The structure of Crystal Structure of A Low Occupancy Fragment Candidate (5-[(4- Isopropylphenyl)Amino]-6-Methyl-1,2,4-Triazin-3(2H)-One) Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the Crystal Structure of A Low Occupancy Fragment Candidate (5-[(4- Isopropylphenyl)Amino]-6-Methyl-1,2,4-Triazin-3(2H)-One) Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain
(pdb code 5kh9). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of A Low Occupancy Fragment Candidate (5-[(4- Isopropylphenyl)Amino]-6-Methyl-1,2,4-Triazin-3(2H)-One) Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain, PDB code: 5kh9: Sodium binding site 1 out of 1 in 5kh9Go back to![]() ![]()
Sodium binding site 1 out
of 1 in the Crystal Structure of A Low Occupancy Fragment Candidate (5-[(4- Isopropylphenyl)Amino]-6-Methyl-1,2,4-Triazin-3(2H)-One) Bound in the Ubiquitin Binding Pocket of the HDAC6 Zinc-Finger Domain
![]() Mono view ![]() Stereo pair view
Reference:
R.J.Harding,
R.Ferreira De Freitas,
P.Collins,
I.Franzoni,
M.Ravichandran,
H.Ouyang,
K.A.Juarez-Ornelas,
M.Lautens,
M.Schapira,
F.Von Delft,
V.Santhakumar,
C.H.Arrowsmith.
Small Molecule Antagonists of the Interaction Between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin. J. Med. Chem. V. 60 9090 2017.
Page generated: Mon Oct 7 22:05:28 2024
ISSN: ISSN 1520-4804 PubMed: 29019676 DOI: 10.1021/ACS.JMEDCHEM.7B00933 |
Last articlesCa in 2V02Ca in 2V3O Ca in 2V3H Ca in 2V0B Ca in 2UZA Ca in 2V01 Ca in 2UX1 Ca in 2UWF Ca in 2UZ0 Ca in 2UVW |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |