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Sodium in PDB 5i7u: Human DPP4 in Complex with A Novel Tricyclic Hetero-Cycle Inhibitor
Enzymatic activity of Human DPP4 in Complex with A Novel Tricyclic Hetero-Cycle Inhibitor
All present enzymatic activity of Human DPP4 in Complex with A Novel Tricyclic Hetero-Cycle Inhibitor:
3.4.14.5;
3.4.14.5;
Protein crystallography data
The structure of Human DPP4 in Complex with A Novel Tricyclic Hetero-Cycle Inhibitor, PDB code: 5i7u
was solved by
G.Scapin,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 93.22 / 1.95 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 118.553, 126.545, 137.854, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 15.4 / 18.7 |
Other elements in 5i7u:
The structure of Human DPP4 in Complex with A Novel Tricyclic Hetero-Cycle Inhibitor also contains other interesting chemical elements:
| Fluorine | (F) | 2 atoms |
Sodium Binding Sites:
The binding sites of Sodium atom in the Human DPP4 in Complex with A Novel Tricyclic Hetero-Cycle Inhibitor
(pdb code 5i7u). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Human DPP4 in Complex with A Novel Tricyclic Hetero-Cycle Inhibitor, PDB code: 5i7u:
In total only one binding site of Sodium was determined in the Human DPP4 in Complex with A Novel Tricyclic Hetero-Cycle Inhibitor, PDB code: 5i7u:
Sodium binding site 1 out of 1 in 5i7u
Go back to
Sodium Binding Sites List in 5i7u
Sodium binding site 1 out
of 1 in the Human DPP4 in Complex with A Novel Tricyclic Hetero-Cycle Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 1 of Human DPP4 in Complex with A Novel Tricyclic Hetero-Cycle Inhibitor within 5.0Å range:
|
Reference:
W.L.Wu,
J.Hao,
M.Domalski,
D.A.Burnett,
D.Pissarnitski,
Z.Zhao,
A.Stamford,
G.Scapin,
Y.D.Gao,
A.Soriano,
T.M.Kelly,
Z.Yao,
M.A.Powles,
S.Chen,
H.Mei,
J.Hwa.
Discovery of Novel Tricyclic Heterocycles As Potent and Selective Dpp-4 Inhibitors For the Treatment of Type 2 Diabetes. Acs Med.Chem.Lett. V. 7 498 2016.
ISSN: ISSN 1948-5875
PubMed: 27190600
DOI: 10.1021/ACSMEDCHEMLETT.6B00027
Page generated: Mon Oct 7 21:32:41 2024
ISSN: ISSN 1948-5875
PubMed: 27190600
DOI: 10.1021/ACSMEDCHEMLETT.6B00027
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