Sodium in PDB 5hpr: Insulin with Proline Analog Hyp at Position B28 in the T2 State

The structure of Insulin with Proline Analog Hyp at Position B28 in the T2 State, PDB code: 5hpr was solved by S.A.Lieblich, K.Y.Fang, J.K.B.Cahn, D.A.Tirrell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	55.33 / 1.33
Space group	I 21 3
Cell size a, b, c (Å), α, β, γ (°)	78.245, 78.245, 78.245, 90.00, 90.00, 90.00
R / Rfree (%)	12.5 / 16.4

The binding sites of Sodium atom in the Insulin with Proline Analog Hyp at Position B28 in the T2 State (pdb code 5hpr). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Insulin with Proline Analog Hyp at Position B28 in the T2 State, PDB code: 5hpr:

Sodium binding site 1 out of 1 in the Insulin with Proline Analog Hyp at Position B28 in the T2 State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Insulin with Proline Analog Hyp at Position B28 in the T2 State within 5.0Å range: probe atom residue distance (Å) B Occ B:Na101 b:76.7 occ:0.50 O A:HOH108 2.7 37.2 0.5 CB B:PHE25 3.7 23.7 1.0 CG B:PHE25 4.1 24.4 1.0 CD1 B:PHE25 4.4 28.9 1.0 CD2 B:PHE25 4.7 32.5 1.0 ND2 A:ASN21 4.8 28.0 1.0 CA B:PHE25 5.0 17.3 1.0

S.A.Lieblich, K.Y.Fang, J.K.B.Cahn, J.Rawson, J.Lebon, H.T.Ku, D.A.Tirrell. 4S-Hydroxylation of Insulin at PROB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc. V. 139 8384 2017.
ISSN: ESSN 1520-5126
PubMed: 28598606
DOI: 10.1021/JACS.7B00794