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Sodium in PDB 4qy9: X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO3, A Cytotoxic Gold(III) Compound

Enzymatic activity of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO3, A Cytotoxic Gold(III) Compound

All present enzymatic activity of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO3, A Cytotoxic Gold(III) Compound:
3.2.1.17;

Protein crystallography data

The structure of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO3, A Cytotoxic Gold(III) Compound, PDB code: 4qy9 was solved by I.Russo Krauss, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.19 / 2.05
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 76.943, 76.943, 37.464, 90.00, 90.00, 90.00
R / Rfree (%) 18.5 / 28.9

Other elements in 4qy9:

The structure of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO3, A Cytotoxic Gold(III) Compound also contains other interesting chemical elements:

Gold (Au) 2 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO3, A Cytotoxic Gold(III) Compound (pdb code 4qy9). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO3, A Cytotoxic Gold(III) Compound, PDB code: 4qy9:

Sodium binding site 1 out of 1 in 4qy9

Go back to Sodium Binding Sites List in 4qy9
Sodium binding site 1 out of 1 in the X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO3, A Cytotoxic Gold(III) Compound


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of X-Ray Structure of the Adduct Between Hen Egg White Lysozyme and AUOXO3, A Cytotoxic Gold(III) Compound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na407

b:39.7
occ:1.00
 O A:SER60 2.1 35.0 1.0
O A:ARG73 2.3 41.7 1.0
O A:HOH536 2.4 43.4 1.0
OG A:SER72 2.5 47.8 1.0
O A:CYS64 2.6 29.6 1.0
O3 A:NO3403 2.6 52.8 1.0
C A:SER60 3.2 37.5 1.0
C A:ARG73 3.4 47.2 1.0
CB A:SER72 3.5 56.6 1.0
N A:NO3403 3.6 50.5 1.0
C A:CYS64 3.7 32.5 1.0
O2 A:NO3403 3.7 57.0 1.0
N A:ARG73 3.8 56.0 1.0
CA A:SER60 3.9 35.0 1.0
C A:SER72 4.0 58.0 1.0
CA A:ARG73 4.2 51.2 1.0
CA A:ASN65 4.2 35.0 1.0
CB A:SER60 4.2 32.9 1.0
N A:ASN74 4.3 44.4 1.0
N A:ARG61 4.3 38.9 1.0
C A:ARG61 4.3 43.7 1.0
N A:ASN65 4.3 34.1 1.0
CA A:SER72 4.4 57.1 1.0
O A:ARG61 4.5 48.1 1.0
N A:CYS64 4.5 31.8 1.0
CA A:ASN74 4.5 39.2 1.0
CB A:THR69 4.5 39.2 1.0
O A:SER72 4.6 57.4 1.0
N A:TRP62 4.6 41.7 1.0
CA A:ARG61 4.6 44.1 1.0
O1 A:NO3403 4.7 52.3 1.0
CB A:ASN74 4.7 37.7 1.0
CA A:CYS64 4.7 29.5 1.0
O A:THR69 4.8 39.1 1.0
ND2 A:ASN65 4.8 54.4 1.0
CG2 A:THR69 4.8 38.5 1.0
N A:TRP63 4.9 31.3 1.0
C A:TRP62 4.9 36.8 1.0
CB A:ASN65 5.0 35.0 1.0

Reference:

I.Russo Krauss, L.Messori, M.A.Cinellu, D.Marasco, R.Sirignano, A.Merlino. Interactions of Gold-Based Drugs with Proteins: the Structure and Stability of the Adduct Formed in the Reaction Between Lysozyme and the Cytotoxic Gold(III) Compound AUOXO3. Dalton Trans 2014.
ISSN: ESSN 1477-9234
PubMed: 25340580
DOI: 10.1039/C4DT02332C
Page generated: Sun Aug 17 21:30:59 2025

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