Sodium in PDB 4nif: Heterodimeric Structure of ERK2 and RSK1

All present enzymatic activity of Heterodimeric Structure of ERK2 and RSK1:
2.7.11.1; 2.7.11.24;

The structure of Heterodimeric Structure of ERK2 and RSK1, PDB code: 4nif was solved by G.Gogl, A.Remenyi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	60.63 / 2.15
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	93.490, 87.850, 116.540, 90.00, 108.22, 90.00
R / Rfree (%)	15.8 / 20.8

The binding sites of Sodium atom in the Heterodimeric Structure of ERK2 and RSK1 (pdb code 4nif). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Heterodimeric Structure of ERK2 and RSK1, PDB code: 4nif:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Heterodimeric Structure of ERK2 and RSK1


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Heterodimeric Structure of ERK2 and RSK1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Na404 b:18.9 occ:1.00 O B:HOH738 2.9 63.4 1.0 O B:HOH515 3.1 26.0 1.0 NH1 B:ARG70 3.3 23.7 1.0 N B:VAL173 3.3 29.5 1.0 CE2 B:PHE331 3.7 27.0 1.0 CD2 B:PHE331 3.8 28.3 1.0 CA B:ARG172 3.9 29.8 1.0 CB B:VAL173 3.9 32.9 1.0 CB B:ARG172 4.0 36.6 1.0 CG2 B:VAL173 4.0 30.7 1.0 NH2 B:ARG70 4.0 21.9 1.0 CZ B:ARG70 4.1 26.5 1.0 C B:ARG172 4.2 34.5 1.0 CA B:VAL173 4.2 30.7 1.0 NH2 B:ARG172 4.2 50.5 1.0 CZ B:ARG172 4.3 48.9 1.0 NE B:ARG172 4.3 49.3 1.0 CG B:ARG172 4.3 46.2 1.0 O B:VAL173 4.6 41.6 1.0 NH1 B:ARG172 4.8 53.1 1.0 C B:VAL173 4.9 36.7 1.0 CZ B:PHE331 4.9 22.6 1.0 CD B:ARG172 5.0 40.5 1.0

Sodium binding site 2 out of 2 in the Heterodimeric Structure of ERK2 and RSK1


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Heterodimeric Structure of ERK2 and RSK1 within 5.0Å range: probe atom residue distance (Å) B Occ E:Na403 b:20.1 occ:1.00 O E:HOH796 2.8 46.4 1.0 O E:HOH524 3.1 29.3 1.0 NH1 E:ARG70 3.2 24.9 1.0 N E:VAL173 3.3 31.0 1.0 CE2 E:PHE331 3.7 33.5 1.0 CD2 E:PHE331 3.8 30.4 1.0 CA E:ARG172 3.9 28.4 1.0 CB E:ARG172 3.9 31.8 1.0 CB E:VAL173 4.0 36.3 1.0 NH2 E:ARG70 4.0 27.4 1.0 CZ E:ARG70 4.1 26.7 1.0 CG2 E:VAL173 4.1 31.7 1.0 C E:ARG172 4.1 33.5 1.0 CZ E:ARG172 4.2 54.3 1.0 NH2 E:ARG172 4.2 48.8 1.0 CA E:VAL173 4.2 32.5 1.0 CG E:ARG172 4.3 53.0 1.0 NE E:ARG172 4.4 60.5 1.0 NH1 E:ARG172 4.5 58.7 1.0 O E:VAL173 4.6 45.8 1.0 CZ E:PHE331 4.9 26.8 1.0 C E:VAL173 4.9 40.5 1.0 CD E:ARG172 5.0 48.5 1.0

G.Gogl, A.Remenyi. Structural Assembly of the Signaling Competent ERK2-RSK1 Complex To Be Published.