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Atomistry » Sodium » PDB 4jes-4jtk » 4jt9 » |
Sodium in PDB 4jt9: Crystal Structure of Human SIRT3 with Elt Inhibitor 3 [14-(4-{2- [(Methylsulfonyl)Amino]Ethyl}Piperidin-1-Yl)Thieno[3,2-D]Pyrimidine- 6-Carboxamide]Protein crystallography data
The structure of Crystal Structure of Human SIRT3 with Elt Inhibitor 3 [14-(4-{2- [(Methylsulfonyl)Amino]Ethyl}Piperidin-1-Yl)Thieno[3,2-D]Pyrimidine- 6-Carboxamide], PDB code: 4jt9
was solved by
H.Dai,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4jt9:
The structure of Crystal Structure of Human SIRT3 with Elt Inhibitor 3 [14-(4-{2- [(Methylsulfonyl)Amino]Ethyl}Piperidin-1-Yl)Thieno[3,2-D]Pyrimidine- 6-Carboxamide] also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the Crystal Structure of Human SIRT3 with Elt Inhibitor 3 [14-(4-{2- [(Methylsulfonyl)Amino]Ethyl}Piperidin-1-Yl)Thieno[3,2-D]Pyrimidine- 6-Carboxamide]
(pdb code 4jt9). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Human SIRT3 with Elt Inhibitor 3 [14-(4-{2- [(Methylsulfonyl)Amino]Ethyl}Piperidin-1-Yl)Thieno[3,2-D]Pyrimidine- 6-Carboxamide], PDB code: 4jt9: Sodium binding site 1 out of 1 in 4jt9Go back to![]() ![]()
Sodium binding site 1 out
of 1 in the Crystal Structure of Human SIRT3 with Elt Inhibitor 3 [14-(4-{2- [(Methylsulfonyl)Amino]Ethyl}Piperidin-1-Yl)Thieno[3,2-D]Pyrimidine- 6-Carboxamide]
![]() Mono view ![]() Stereo pair view
Reference:
J.S.Disch,
G.Evindar,
C.H.Chiu,
C.A.Blum,
H.Dai,
L.Jin,
E.Schuman,
K.E.Lind,
S.L.Belyanskaya,
J.Deng,
F.Coppo,
L.Aquilani,
T.L.Graybill,
J.W.Cuozzo,
S.Lavu,
C.Mao,
G.P.Vlasuk,
R.B.Perni.
Discovery of Thieno[3,2-D]Pyrimidine-6-Carboxamides As Potent Inhibitors of SIRT1, SIRT2, and SIRT3. J.Med.Chem. V. 56 3666 2013.
Page generated: Mon Oct 7 16:22:03 2024
ISSN: ISSN 0022-2623 PubMed: 23570514 DOI: 10.1021/JM400204K |
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