Atomistry » Sodium » PDB 4gxj-4hfc » 4hfc
Atomistry »
  Sodium »
    PDB 4gxj-4hfc »
      4hfc »

Sodium in PDB 4hfc: The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol

Protein crystallography data

The structure of The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol, PDB code: 4hfc was solved by L.Sauguet, R.J.Howard, L.Malherbe, U.S.Lee, P.J.Corringer, R.A.Harris, M.Delarue, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 3.05
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 180.880, 133.140, 159.350, 90.00, 102.22, 90.00
R / Rfree (%) 19.2 / 22

Other elements in 4hfc:

The structure of The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol also contains other interesting chemical elements:

Bromine (Br) 5 atoms
Chlorine (Cl) 7 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol (pdb code 4hfc). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 6 binding sites of Sodium where determined in the The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol, PDB code: 4hfc:
Jump to Sodium binding site number: 1; 2; 3; 4; 5; 6;

Sodium binding site 1 out of 6 in 4hfc

Go back to Sodium Binding Sites List in 4hfc
Sodium binding site 1 out of 6 in the The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na406

b:89.1
occ:1.00
 OG1 C:THR226 4.1 94.5 1.0
OG1 B:THR226 4.1 89.6 1.0
OG1 A:THR226 4.2 93.4 1.0
OG1 E:THR226 4.5 88.4 1.0
OG1 D:THR226 4.7 88.8 1.0
CG2 B:THR226 4.8 81.5 1.0
CG2 C:THR226 4.9 83.7 1.0
CG2 A:THR226 4.9 83.5 1.0
O A:HOH516 4.9 55.0 1.0

Sodium binding site 2 out of 6 in 4hfc

Go back to Sodium Binding Sites List in 4hfc
Sodium binding site 2 out of 6 in the The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na407

b:86.1
occ:1.00
 O A:ILE71 2.6 91.4 1.0
O A:PRO68 3.2 0.2 1.0
C A:ILE71 3.6 92.6 1.0
N A:ILE73 3.8 82.4 1.0
CA A:TRP72 4.0 86.0 1.0
CG1 A:VAL5 4.1 0.2 1.0
N A:TRP72 4.2 87.7 1.0
C A:PRO68 4.2 0.9 1.0
C A:TRP72 4.3 89.4 1.0
CD1 A:ILE73 4.3 88.7 1.0
CG1 A:ILE73 4.3 82.4 1.0
CB A:ILE73 4.5 81.5 1.0
O A:GLU69 4.5 0.9 1.0
CA A:ILE73 4.7 80.0 1.0
C A:GLU69 4.8 0.5 1.0
CA A:GLU69 4.8 0.7 1.0
CA A:ILE71 4.8 92.4 1.0
N A:ILE71 4.8 94.5 1.0
CB A:VAL5 4.9 0.1 1.0
N A:GLU69 4.9 0.6 1.0

Sodium binding site 3 out of 6 in 4hfc

Go back to Sodium Binding Sites List in 4hfc
Sodium binding site 3 out of 6 in the The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Na406

b:84.2
occ:1.00
 O B:ILE71 2.6 84.8 1.0
O B:PRO68 3.0 93.1 1.0
C B:ILE71 3.7 83.2 1.0
C B:PRO68 4.0 92.5 1.0
N B:ILE73 4.1 74.6 1.0
CG1 B:VAL5 4.1 0.7 1.0
O B:GLU69 4.2 93.2 1.0
CA B:TRP72 4.2 77.6 1.0
N B:TRP72 4.4 78.1 1.0
CD1 B:ILE73 4.4 81.9 1.0
C B:GLU69 4.4 91.9 1.0
CA B:GLU69 4.5 90.4 1.0
C B:TRP72 4.5 80.2 1.0
CG1 B:ILE73 4.6 72.6 1.0
N B:GLU69 4.6 90.3 1.0
N B:ILE71 4.7 80.3 1.0
CB B:ILE73 4.7 72.8 1.0
CA B:ILE71 4.8 78.7 1.0
CB B:VAL5 4.9 0.3 1.0
CA B:ILE73 5.0 71.7 1.0

Sodium binding site 4 out of 6 in 4hfc

Go back to Sodium Binding Sites List in 4hfc
Sodium binding site 4 out of 6 in the The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Na405

b:76.3
occ:1.00
 O C:ILE71 2.8 89.1 1.0
O C:PRO68 3.3 90.1 1.0
N C:ILE73 3.5 80.4 1.0
C C:ILE71 3.9 91.2 1.0
CB C:ILE73 4.0 79.1 1.0
CD1 C:ILE73 4.0 82.1 1.0
CG1 C:ILE73 4.1 79.5 1.0
CA C:TRP72 4.1 83.6 1.0
C C:TRP72 4.2 86.7 1.0
CA C:ILE73 4.3 77.8 1.0
C C:PRO68 4.4 91.5 1.0
N C:TRP72 4.5 85.0 1.0
O C:ILE73 4.6 85.5 1.0
CG1 C:VAL5 4.7 0.4 1.0
C C:ILE73 5.0 85.2 1.0

Sodium binding site 5 out of 6 in 4hfc

Go back to Sodium Binding Sites List in 4hfc
Sodium binding site 5 out of 6 in the The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 5 of The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Na405

b:96.0
occ:1.00
 O D:ILE71 2.6 90.7 1.0
O D:PRO68 3.2 0.0 1.0
N D:ILE73 3.5 82.4 1.0
C D:ILE71 3.7 92.2 1.0
CA D:TRP72 4.0 85.7 1.0
CD1 D:ILE73 4.1 91.9 1.0
C D:TRP72 4.1 87.7 1.0
CG1 D:ILE73 4.1 83.3 1.0
CB D:ILE73 4.2 82.5 1.0
C D:PRO68 4.2 0.4 1.0
N D:TRP72 4.2 87.2 1.0
CA D:ILE73 4.4 80.6 1.0
O D:ILE73 4.7 87.4 1.0
O D:GLU69 4.8 0.8 1.0
CA D:GLU69 4.9 99.3 1.0
CA D:ILE71 4.9 92.0 1.0
N D:GLU69 5.0 0.5 1.0
N D:ILE71 5.0 94.7 1.0
C D:GLU69 5.0 0.8 1.0

Sodium binding site 6 out of 6 in 4hfc

Go back to Sodium Binding Sites List in 4hfc
Sodium binding site 6 out of 6 in the The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 6 of The Glic Pentameric Ligand-Gated Ion Channel F14'A Ethanol-Sensitive Mutant Complexed to 2-Bromo-Ethanol within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Na406

b:97.0
occ:1.00
 O E:ILE71 2.7 92.3 1.0
O E:PRO68 2.8 99.9 1.0
C E:PRO68 3.8 0.7 1.0
C E:ILE71 3.8 93.3 1.0
CD1 E:ILE73 3.8 82.5 1.0
N E:ILE73 3.9 78.5 1.0
CG1 E:ILE73 4.1 78.4 1.0
CB E:ILE73 4.2 77.7 1.0
CA E:TRP72 4.4 85.3 1.0
C E:TRP72 4.5 84.8 1.0
N E:GLU69 4.5 99.8 1.0
CA E:GLU69 4.5 99.8 1.0
N E:TRP72 4.5 87.6 1.0
O E:GLU69 4.5 0.7 1.0
CG1 E:VAL5 4.7 0.1 1.0
C E:GLU69 4.7 0.5 1.0
CA E:ILE73 4.7 75.4 1.0
CA E:PRO68 4.8 93.2 1.0
N E:ILE71 4.9 92.8 1.0
CA E:ILE71 5.0 91.2 1.0

Reference:

L.Sauguet, R.J.Howard, L.Malherbe, U.S.Lee, P.J.Corringer, R.A.Harris, M.Delarue. Structural Basis For Potentiation By Alcohols and Anaesthetics in A Ligand-Gated Ion Channel. Nat Commun V. 4 1697 2013.
ISSN: ESSN 2041-1723
PubMed: 23591864
DOI: 10.1038/NCOMMS2682
Page generated: Mon Oct 7 15:47:10 2024

Last articles

Zn in 9MJ5
Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy