Sodium in PDB 4fxl: Crystal Structure of the D76N Beta-2 Microglobulin Mutant

The structure of Crystal Structure of the D76N Beta-2 Microglobulin Mutant, PDB code: 4fxl was solved by S.Ricagno, V.Bellotti, M.B.Pepys, M.Stoppini, M.Bolognesi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	18.80 / 1.40
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	76.220, 28.420, 52.260, 90.00, 126.54, 90.00
R / Rfree (%)	13 / 18.6

The binding sites of Sodium atom in the Crystal Structure of the D76N Beta-2 Microglobulin Mutant (pdb code 4fxl). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of the D76N Beta-2 Microglobulin Mutant, PDB code: 4fxl:

Sodium binding site 1 out of 1 in the Crystal Structure of the D76N Beta-2 Microglobulin Mutant


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of the D76N Beta-2 Microglobulin Mutant within 5.0Å range: probe atom residue distance (Å) B Occ A:Na101 b:26.6 occ:1.00 O A:HOH251 2.4 13.3 1.0 OD1 A:ASN83 2.5 19.4 0.8 CA A:ASN83 2.9 10.3 1.0 N A:HIS84 3.0 9.8 1.0 CB A:ASN83 3.0 12.9 1.0 CG A:ASN83 3.1 17.3 0.8 O A:LEU87 3.3 19.4 1.0 O A:HIS84 3.3 9.1 1.0 C A:ASN83 3.4 10.2 1.0 O A:HOH252 3.4 25.8 1.0 O A:HOH232 3.5 28.5 1.0 CB A:LEU87 3.9 12.8 1.0 N A:PRO90 4.0 14.0 1.0 C A:HIS84 4.1 9.0 1.0 O A:GLN89 4.1 15.0 1.0 CA A:HIS84 4.1 8.9 1.0 CA A:PRO90 4.1 14.2 1.0 C A:GLN89 4.2 13.5 1.0 N A:ASN83 4.2 9.6 1.0 C A:LEU87 4.3 13.3 1.0 O A:VAL82 4.3 11.3 1.0 ND2 A:ASN83 4.4 22.6 0.8 O A:ASN83 4.6 10.6 1.0 CA A:LEU87 4.7 12.6 1.0 C A:VAL82 4.7 10.5 1.0 CD1 A:LEU87 4.8 16.6 1.0 CD A:PRO90 4.8 20.0 1.0 CG A:PRO90 4.8 22.7 1.0 O A:HOH221 4.8 22.6 1.0 O A:HOH261 4.9 57.2 1.0 N A:GLN89 4.9 14.6 1.0 CA A:GLN89 4.9 15.7 1.0 CB A:PRO90 4.9 17.9 1.0 CG A:LEU87 5.0 14.3 1.0

S.Valleix, J.D.Gillmore, F.Bridoux, P.P.Mangione, A.Dogan, B.Nedelec, M.Boimard, G.Touchard, J.M.Goujon, C.Lacombe, P.Lozeron, D.Adams, C.Lacroix, T.Maisonobe, V.Plante-Bordeneuve, J.A.Vrana, J.D.Theis, S.Giorgetti, R.Porcari, S.Ricagno, M.Bolognesi, M.Stoppini, M.Delpech, M.B.Pepys, P.N.Hawkins, V.Bellotti. Hereditary Systemic Amyloidosis Due to ASP76ASN Variant Beta-2-Microglobulin. N.Engl.J.Med. V. 366 2276 2012.
ISSN: ISSN 0028-4793
PubMed: 22693999
DOI: 10.1056/NEJMOA1201356