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Sodium in PDB 3opz: Crystal Structure of Trans-Sialidase in Complex with the Fab Fragment of A Neutralizing Monoclonal Igg Antibody

Enzymatic activity of Crystal Structure of Trans-Sialidase in Complex with the Fab Fragment of A Neutralizing Monoclonal Igg Antibody

All present enzymatic activity of Crystal Structure of Trans-Sialidase in Complex with the Fab Fragment of A Neutralizing Monoclonal Igg Antibody:
3.2.1.18;

Protein crystallography data

The structure of Crystal Structure of Trans-Sialidase in Complex with the Fab Fragment of A Neutralizing Monoclonal Igg Antibody, PDB code: 3opz was solved by N.Larrieux, R.Muia, O.Campetella, A.Buschiazzo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.79 / 3.40
Space group P 31
Cell size a, b, c (Å), α, β, γ (°) 178.140, 178.140, 140.710, 90.00, 90.00, 120.00
R / Rfree (%) 16.4 / 20.5

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of Trans-Sialidase in Complex with the Fab Fragment of A Neutralizing Monoclonal Igg Antibody (pdb code 3opz). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Trans-Sialidase in Complex with the Fab Fragment of A Neutralizing Monoclonal Igg Antibody, PDB code: 3opz:

Sodium binding site 1 out of 1 in 3opz

Go back to Sodium Binding Sites List in 3opz
Sodium binding site 1 out of 1 in the Crystal Structure of Trans-Sialidase in Complex with the Fab Fragment of A Neutralizing Monoclonal Igg Antibody


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Trans-Sialidase in Complex with the Fab Fragment of A Neutralizing Monoclonal Igg Antibody within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na635

b:38.5
occ:1.00
 NZ A:LYS22 3.2 60.0 1.0
O A:ARG87 3.7 48.6 1.0
CB A:ARG87 4.0 46.5 1.0
CD A:ARG87 4.0 46.4 1.0
CA A:ARG87 4.1 46.1 1.0
C A:ARG87 4.3 47.7 1.0
CE A:LYS22 4.3 58.7 1.0
CD1 A:LEU62 4.5 39.6 1.0
CD A:LYS22 4.5 56.9 1.0
O A:SER89 4.5 47.4 1.0
CZ A:PHE20 4.6 57.9 1.0
CG A:ARG87 4.6 46.5 1.0
CD2 A:LEU62 4.7 39.8 1.0
CG A:LYS22 4.9 55.6 1.0

Reference:

A.Buschiazzo, R.Muia, N.Larrieux, T.Pitcovsky, J.Mucci, O.Campetella. Trypanosoma Cruzi Trans-Sialidase in Complex with A Neutralizing Antibody: Structure/Function Studies Towards the Rational Design of Inhibitors. Plos Pathog. V. 8 02474 2012.
ISSN: ISSN 1553-7366
PubMed: 22241998
DOI: 10.1371/JOURNAL.PPAT.1002474
Page generated: Mon Oct 7 12:05:16 2024

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