Atomistry » Sodium » PDB 3icf-3ivu » 3isb
Atomistry »
  Sodium »
    PDB 3icf-3ivu »
      3isb »

Sodium in PDB 3isb: Binary Complex of Human Dna Polymerase Beta with A Gapped Dna

Enzymatic activity of Binary Complex of Human Dna Polymerase Beta with A Gapped Dna

All present enzymatic activity of Binary Complex of Human Dna Polymerase Beta with A Gapped Dna:
2.7.7.7;

Protein crystallography data

The structure of Binary Complex of Human Dna Polymerase Beta with A Gapped Dna, PDB code: 3isb was solved by W.A.Beard, D.D.Shock, V.K.Batra, L.C.Pedersen, S.H.Wilson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 21.86 / 2.00
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 54.380, 79.240, 54.880, 90.00, 105.49, 90.00
R / Rfree (%) 21.1 / 27.1

Sodium Binding Sites:

The binding sites of Sodium atom in the Binary Complex of Human Dna Polymerase Beta with A Gapped Dna (pdb code 3isb). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 4 binding sites of Sodium where determined in the Binary Complex of Human Dna Polymerase Beta with A Gapped Dna, PDB code: 3isb:
Jump to Sodium binding site number: 1; 2; 3; 4;

Sodium binding site 1 out of 4 in 3isb

Go back to Sodium Binding Sites List in 3isb
Sodium binding site 1 out of 4 in the Binary Complex of Human Dna Polymerase Beta with A Gapped Dna


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Binary Complex of Human Dna Polymerase Beta with A Gapped Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na401

b:7.7
occ:1.00
O A:THR101 2.3 13.8 1.0
OP1 P:DG9 2.4 8.3 1.0
O A:ILE106 2.4 10.1 1.0
O P:HOH12 2.4 11.4 1.0
O A:VAL103 2.5 12.9 1.0
O P:HOH11 2.7 11.1 1.0
NA A:NA403 3.2 24.2 1.0
C A:THR101 3.3 13.3 1.0
C A:VAL103 3.4 11.9 1.0
C A:ILE106 3.4 8.8 1.0
P P:DG9 3.5 10.4 1.0
OP2 P:DG9 3.7 10.3 1.0
N A:ILE106 3.8 9.2 1.0
CA A:THR101 3.9 12.4 1.0
CA A:SER104 3.9 10.5 1.0
N A:GLY105 3.9 10.0 1.0
N A:SER104 4.0 10.8 1.0
N A:VAL103 4.1 12.3 1.0
CA A:ILE106 4.2 8.7 1.0
C A:SER104 4.3 10.5 1.0
C A:ARG102 4.3 12.4 1.0
CB A:THR101 4.3 12.1 1.0
N A:ARG102 4.3 13.7 1.0
N A:GLY107 4.4 8.0 1.0
CA A:VAL103 4.4 12.0 1.0
O3' P:DC8 4.5 9.8 1.0
CB A:ILE106 4.6 10.2 1.0
CA A:GLY107 4.6 9.8 1.0
C A:GLY105 4.6 9.1 1.0
O5' P:DG9 4.6 10.6 1.0
CA A:ARG102 4.6 12.7 1.0
O A:ARG102 4.8 10.6 1.0
CA A:GLY105 4.9 9.3 1.0
O A:LEU100 4.9 10.5 1.0
O A:HOH566 5.0 15.2 1.0
O A:HOH739 5.0 33.0 1.0

Sodium binding site 2 out of 4 in 3isb

Go back to Sodium Binding Sites List in 3isb
Sodium binding site 2 out of 4 in the Binary Complex of Human Dna Polymerase Beta with A Gapped Dna


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Binary Complex of Human Dna Polymerase Beta with A Gapped Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na402

b:24.1
occ:1.00
O A:VAL65 2.1 19.2 1.0
O D:HOH6 2.2 23.0 1.0
O A:LYS60 2.3 25.1 1.0
OP1 D:DC3 2.7 21.2 1.0
O A:LEU62 2.8 28.0 1.0
O A:HOH690 2.9 32.2 1.0
C A:VAL65 3.2 16.8 1.0
C A:LYS60 3.4 25.8 1.0
P D:DC3 3.7 18.3 1.0
C A:LEU62 3.8 27.4 1.0
OP2 D:DC3 3.8 15.9 1.0
N A:VAL65 3.8 18.4 1.0
CG A:LYS60 3.9 26.6 1.0
CA A:VAL65 4.0 16.3 1.0
CA A:LYS60 4.0 24.2 1.0
O D:HOH533 4.2 43.2 1.0
N A:GLY66 4.2 16.6 1.0
CB A:VAL65 4.3 14.2 1.0
N A:LEU62 4.3 27.3 1.0
C A:LYS61 4.3 28.2 1.0
N A:GLY64 4.4 23.3 1.0
CA A:GLY66 4.4 13.7 1.0
CA A:PRO63 4.4 25.5 1.0
N A:LYS61 4.4 26.4 1.0
N A:PRO63 4.5 27.1 1.0
NZ A:LYS60 4.6 28.2 1.0
O3' D:DT2 4.6 20.0 1.0
O A:LYS61 4.6 29.1 1.0
CB A:LYS60 4.6 24.3 1.0
CA A:LEU62 4.6 28.1 1.0
CA A:LYS61 4.7 27.1 1.0
C A:PRO63 4.8 23.8 1.0
C A:GLY64 4.9 19.7 1.0
O5' D:DC3 4.9 20.7 1.0
O A:ALA59 4.9 21.4 1.0
CG1 A:VAL65 5.0 11.3 1.0

Sodium binding site 3 out of 4 in 3isb

Go back to Sodium Binding Sites List in 3isb
Sodium binding site 3 out of 4 in the Binary Complex of Human Dna Polymerase Beta with A Gapped Dna


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Binary Complex of Human Dna Polymerase Beta with A Gapped Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na403

b:24.2
occ:1.00
O P:HOH12 2.4 11.4 1.0
O A:HOH566 2.5 15.2 1.0
O A:THR101 2.6 13.8 1.0
O A:HOH687 2.6 22.8 1.0
O A:HOH341 2.7 26.1 1.0
O P:HOH11 2.7 11.1 1.0
NA A:NA401 3.2 7.7 1.0
C A:THR101 3.6 13.3 1.0
O A:HOH491 4.1 32.1 1.0
CA A:ARG102 4.2 12.7 1.0
N A:ARG102 4.3 13.7 1.0
CB A:THR101 4.4 12.1 1.0
O A:HOH739 4.4 33.0 1.0
NZ A:LYS27 4.4 22.6 1.0
OG1 A:THR101 4.5 12.5 1.0
CA A:THR101 4.6 12.4 1.0
C A:ARG102 4.6 12.4 1.0
O P:HOH134 4.7 18.0 1.0
OP1 P:DG9 4.7 8.3 1.0
OP2 P:DG9 4.7 10.3 1.0
O A:HOH688 4.8 26.6 1.0
O A:HOH552 4.8 22.2 1.0
O A:ARG102 4.9 10.6 1.0

Sodium binding site 4 out of 4 in 3isb

Go back to Sodium Binding Sites List in 3isb
Sodium binding site 4 out of 4 in the Binary Complex of Human Dna Polymerase Beta with A Gapped Dna


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of Binary Complex of Human Dna Polymerase Beta with A Gapped Dna within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na404

b:21.8
occ:1.00
O A:HOH722 2.1 33.5 1.0
O A:HOH568 2.1 16.6 1.0
OG A:SER171 2.3 13.9 1.0
CB A:SER171 3.4 13.8 1.0
N A:SER171 3.8 11.4 1.0
O A:HOH382 3.9 38.5 1.0
CA A:SER171 4.2 12.9 1.0
O A:HOH549 4.3 16.4 1.0
OD1 A:ASP170 4.5 16.1 1.0
C A:SER171 4.8 15.3 1.0
N A:GLU172 4.9 15.4 1.0
C A:ASP170 4.9 12.1 1.0

Reference:

W.A.Beard, D.D.Shock, V.K.Batra, L.C.Pedersen, S.H.Wilson. Dna Polymerase Beta Substrate Specificity: Side Chain Modulation of the "A-Rule". J.Biol.Chem. V. 284 31680 2009.
ISSN: ISSN 0021-9258
PubMed: 19759017
DOI: 10.1074/JBC.M109.029843
Page generated: Sun Aug 17 15:50:37 2025

Last articles

Mn in 9LJU
Mn in 9LJW
Mn in 9LJS
Mn in 9LJR
Mn in 9LJT
Mn in 9LJV
Mg in 9UA2
Mg in 9R96
Mg in 9VM1
Mg in 9P01
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy