Sodium in PDB 3h42: Crystal Structure of PCSK9 in Complex with Fab From Ldlr Competitive Antibody

The structure of Crystal Structure of PCSK9 in Complex with Fab From Ldlr Competitive Antibody, PDB code: 3h42 was solved by D.E.Piper, N.P.C.Walker, W.G.Romanow, S.T.Thibault, M.M.Tsai, E.Yang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.00 / 2.30
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	264.721, 137.352, 69.885, 90.00, 102.84, 90.00
R / Rfree (%)	19.1 / 20.9

The binding sites of Sodium atom in the Crystal Structure of PCSK9 in Complex with Fab From Ldlr Competitive Antibody (pdb code 3h42). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of PCSK9 in Complex with Fab From Ldlr Competitive Antibody, PDB code: 3h42:

Sodium binding site 1 out of 1 in the Crystal Structure of PCSK9 in Complex with Fab From Ldlr Competitive Antibody


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of PCSK9 in Complex with Fab From Ldlr Competitive Antibody within 5.0Å range: probe atom residue distance (Å) B Occ B:Na1 b:62.6 occ:1.00 OG1 B:THR335 2.9 28.2 1.0 O B:CYS358 2.9 34.5 1.0 O B:ALA330 2.9 38.5 1.0 O B:HOH106 3.0 67.7 1.0 O B:VAL333 3.1 39.2 1.0 OD2 B:ASP360 3.3 44.9 1.0 O B:ALA328 3.4 29.0 1.0 CB B:THR335 3.7 28.3 1.0 O B:PRO331 3.9 51.4 1.0 C B:ALA330 3.9 39.9 1.0 C B:CYS358 3.9 35.0 1.0 CA B:PRO331 4.1 47.5 1.0 CG B:ASP360 4.2 44.0 1.0 C B:PRO331 4.2 48.7 1.0 C B:VAL333 4.3 36.6 1.0 CA B:CYS358 4.3 35.3 1.0 N B:THR335 4.4 29.0 1.0 OD1 B:ASP360 4.4 46.3 1.0 N B:PRO331 4.4 44.3 1.0 O B:HOH105 4.5 39.6 1.0 C B:ALA328 4.5 30.0 1.0 CB B:CYS358 4.6 36.5 1.0 C B:SER329 4.7 33.1 1.0 N B:ALA330 4.7 34.5 1.0 CA B:THR335 4.7 26.9 1.0 CG2 B:THR335 4.8 28.1 1.0 N B:VAL333 4.8 40.2 1.0 O B:SER329 4.9 34.5 1.0 CA B:ALA330 5.0 37.6 1.0 CA B:VAL333 5.0 37.2 1.0

J.C.Chan, D.E.Piper, Q.Cao, D.Liu, C.King, W.Wang, J.Tang, Q.Liu, J.Higbee, Z.Xia, Y.Di, S.Shetterly, Z.Arimura, H.Salomonis, W.G.Romanow, S.T.Thibault, R.Zhang, P.Cao, X.P.Yang, T.Yu, M.Lu, M.W.Retter, G.Kwon, K.Henne, O.Pan, M.M.Tsai, B.Fuchslocher, E.Yang, L.Zhou, K.J.Lee, M.Daris, J.Sheng, Y.Wang, W.D.Shen, W.C.Yeh, M.Emery, N.P.Walker, B.Shan, M.Schwarz, S.M.Jackson. From the Cover: A Proprotein Convertase Subtilisin/Kexin Type 9 Neutralizing Antibody Reduces Serum Cholesterol in Mice and Nonhuman Primates. Proc.Natl.Acad.Sci.Usa V. 106 9820 2009.
ISSN: ISSN 0027-8424
PubMed: 19443683
DOI: 10.1073/PNAS.0903849106