Sodium in PDB 3g1n: Catalytic Domain of the Human E3 Ubiquitin-Protein Ligase HUWE1

The structure of Catalytic Domain of the Human E3 Ubiquitin-Protein Ligase HUWE1, PDB code: 3g1n was solved by J.R.Walker, L.Qiu, Y.Li, T.Davis, W.Tempel, J.Weigelt, C.Bountra, C.H.Arrowsmith, A.M.Edwards, A.Botchkarev, S.Dhe-Paganon, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.30 / 2.60
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	176.530, 72.213, 77.238, 90.00, 106.94, 90.00
R / Rfree (%)	21.4 / 27.9

The binding sites of Sodium atom in the Catalytic Domain of the Human E3 Ubiquitin-Protein Ligase HUWE1 (pdb code 3g1n). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Catalytic Domain of the Human E3 Ubiquitin-Protein Ligase HUWE1, PDB code: 3g1n:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Catalytic Domain of the Human E3 Ubiquitin-Protein Ligase HUWE1


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Catalytic Domain of the Human E3 Ubiquitin-Protein Ligase HUWE1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na5001 b:27.8 occ:1.00 O A:THR4340 2.4 27.4 1.0 O A:THR4301 2.4 28.8 1.0 OD1 A:ASP4087 2.5 25.5 1.0 OD1 A:ASN4343 2.6 24.3 1.0 C A:THR4340 3.4 27.6 1.0 CG A:ASP4087 3.4 27.4 1.0 C A:THR4301 3.5 28.6 1.0 CG A:ASN4343 3.6 23.7 1.0 CB A:ASP4087 3.9 27.7 1.0 CA A:ASP4087 3.9 28.0 1.0 O A:GLU4315 3.9 29.0 1.0 CA A:THR4301 4.0 28.6 1.0 N A:CYS4341 4.1 25.0 1.0 CA A:CYS4341 4.2 24.2 1.0 ND2 A:ASN4343 4.2 23.5 1.0 CB A:THR4340 4.2 27.7 1.0 CA A:THR4340 4.3 27.7 1.0 O A:GLY4086 4.4 27.8 1.0 OD2 A:ASP4087 4.4 28.4 1.0 O A:ASP4087 4.5 28.2 1.0 N A:ASN4343 4.6 23.2 1.0 OG1 A:THR4340 4.6 28.0 1.0 C A:CYS4341 4.6 23.6 1.0 N A:GLY4302 4.6 28.4 1.0 CG2 A:THR4301 4.7 28.1 1.0 C A:ASP4087 4.7 28.3 1.0 CA A:ASN4343 4.7 23.5 1.0 CB A:THR4301 4.8 28.5 1.0 CB A:ASN4343 4.8 23.4 1.0 OG1 A:THR4301 4.9 29.4 1.0 O A:CYS4341 4.9 23.1 1.0 N A:ASP4087 4.9 27.9 1.0 CA A:GLY4316 4.9 30.3 1.0 CA A:GLY4302 4.9 27.9 1.0 C A:GLY4086 5.0 28.0 1.0

Sodium binding site 2 out of 2 in the Catalytic Domain of the Human E3 Ubiquitin-Protein Ligase HUWE1


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Catalytic Domain of the Human E3 Ubiquitin-Protein Ligase HUWE1 within 5.0Å range: probe atom residue distance (Å) B Occ B:Na5002 b:30.9 occ:1.00 O B:HOH5138 2.4 7.9 1.0 O B:THR4301 2.5 28.5 1.0 OD1 B:ASN4343 2.6 25.9 1.0 O B:THR4340 2.6 27.4 1.0 OD1 B:ASP4087 3.2 24.8 1.0 C B:THR4301 3.5 28.8 1.0 CG B:ASN4343 3.6 25.0 1.0 C B:THR4340 3.6 27.7 1.0 CA B:ASP4087 3.8 26.8 1.0 CB B:ASP4087 3.9 26.7 1.0 CG B:ASP4087 3.9 26.0 1.0 O B:GLU4315 4.0 30.1 1.0 OG1 B:THR4301 4.0 31.2 1.0 ND2 B:ASN4343 4.0 24.8 1.0 CA B:THR4301 4.0 29.2 1.0 O B:ASP4087 4.1 27.1 1.0 N B:CYS4341 4.4 25.9 1.0 CA B:THR4340 4.4 27.4 1.0 C B:ASP4087 4.4 27.1 1.0 CB B:THR4340 4.4 27.4 1.0 CA B:CYS4341 4.5 25.4 1.0 O B:GLY4086 4.6 26.5 1.0 CB B:THR4301 4.6 29.3 1.0 N B:ASN4343 4.6 24.6 1.0 N B:GLY4302 4.7 28.1 1.0 OG1 B:THR4340 4.8 27.4 1.0 O B:HOH5108 4.8 13.4 1.0 CB B:ASN4343 4.8 24.7 1.0 CA B:ASN4343 4.8 24.8 1.0 C B:CYS4341 4.8 24.5 1.0 N B:ASP4087 4.9 26.7 1.0

J.R.Walker, L.Qiu, Y.Li, T.Davis, W.Tempel, J.Weigelt, C.Bountra, C.H.Arrowsmith, A.M.Edwards, A.Botchkarev, S.Dhe-Paganon. Hect Domain of Human HUWE1/Mule To Be Published.