Atomistry » Sodium » PDB 2yfa-2zgb » 2z4o
Atomistry »
  Sodium »
    PDB 2yfa-2zgb »
      2z4o »

Sodium in PDB 2z4o: Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-98065

Enzymatic activity of Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-98065

All present enzymatic activity of Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-98065:
3.4.23.16;

Protein crystallography data

The structure of Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-98065, PDB code: 2z4o was solved by Y.F.Wang, Y.Tie, P.I.Boross, J.Tozser, A.K.Ghosh, R.W.Harrison, I.T.Weber, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.60
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 58.250, 85.832, 45.967, 90.00, 90.00, 90.00
R / Rfree (%) 14.4 / 20.5

Other elements in 2z4o:

The structure of Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-98065 also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Sodium Binding Sites:

The binding sites of Sodium atom in the Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-98065 (pdb code 2z4o). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-98065, PDB code: 2z4o:

Sodium binding site 1 out of 1 in 2z4o

Go back to Sodium Binding Sites List in 2z4o
Sodium binding site 1 out of 1 in the Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-98065


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Wild Type Hiv-1 Protease with Potent Antiviral Inhibitor Grl-98065 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na500

b:23.9
occ:1.00
 O A:HOH510 2.3 21.1 1.0
O A:HOH515 2.3 21.8 1.0
O A:HOH530 2.3 29.4 1.0
O A:ASP60 2.4 15.4 1.0
O A:HOH522 2.5 25.0 1.0
O A:HOH532 2.6 25.8 1.0
C A:ASP60 3.5 14.6 1.0
N A:ASP60 3.7 12.9 1.0
CA A:ASP60 4.1 14.2 1.0
O A:ARG41 4.1 18.4 1.0
CB A:ASP60 4.4 16.6 1.0
N A:ARG41 4.5 23.8 1.0
N A:GLN61 4.5 14.3 1.0
CB A:GLN61 4.5 17.7 1.0
O A:HOH580 4.6 36.9 1.0
O A:HOH614 4.6 39.3 1.0
O A:HOH605 4.6 25.4 0.5
CD1 A:ILE62 4.6 15.5 1.0
O A:GLN61 4.7 17.4 1.0
C A:TYR59 4.7 10.7 1.0
O A:PRO39 4.7 20.5 1.0
C A:GLN61 4.8 14.7 1.0
OE1 A:GLN61 4.8 37.3 1.0
CA A:GLN61 4.8 14.8 1.0
CA A:GLY40 4.9 23.3 1.0

Reference:

Y.F.Wang, Y.Tie, P.I.Boross, J.Tozser, A.K.Ghosh, R.W.Harrison, I.T.Weber. Potent New Antiviral Compound Shows Similar Inhibition and Structural Interactions with Drug Resistant Mutants and Wild Type Hiv-1 Protease. J.Med.Chem. V. 50 4509 2007.
ISSN: ISSN 0022-2623
PubMed: 17696515
DOI: 10.1021/JM070482Q
Page generated: Mon Oct 7 05:30:12 2024

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy