Sodium in PDB 2wnt: Crystal Structure of the Human Ribosomal Protein S6 Kinase

All present enzymatic activity of Crystal Structure of the Human Ribosomal Protein S6 Kinase:
2.7.11.1;

The structure of Crystal Structure of the Human Ribosomal Protein S6 Kinase, PDB code: 2wnt was solved by J.R.C.Muniz, J.M.Elkins, J.Wang, E.Ugochukwu, E.Salah, O.King, S.Picaud, F.Von Delft, C.Bountra, C.H.Arrowsmith, J.Weigelt, A.Edwards, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.52 / 2.40
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	39.660, 142.910, 60.960, 90.00, 94.90, 90.00
R / Rfree (%)	18.9 / 24

The structure of Crystal Structure of the Human Ribosomal Protein S6 Kinase also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Sodium atom in the Crystal Structure of the Human Ribosomal Protein S6 Kinase (pdb code 2wnt). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 3 binding sites of Sodium where determined in the Crystal Structure of the Human Ribosomal Protein S6 Kinase, PDB code: 2wnt:
Jump to Sodium binding site number: 1; 2; 3;

Sodium binding site 1 out of 3 in the Crystal Structure of the Human Ribosomal Protein S6 Kinase


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of the Human Ribosomal Protein S6 Kinase within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1709 b:39.9 occ:1.00 O A:ILE472 2.6 43.5 1.0 O A:HIS469 2.7 38.9 1.0 OG1 A:THR474 2.7 42.8 1.0 O A:GLY467 2.9 58.3 1.0 O A:HOH2012 3.0 54.9 1.0 O A:HOH2011 3.0 48.5 1.0 C A:HIS469 3.6 42.0 1.0 C A:ILE472 3.8 34.3 1.0 CB A:THR474 3.9 50.1 1.0 C A:GLY467 3.9 59.6 1.0 C A:GLN468 4.0 46.5 1.0 N A:THR474 4.0 46.8 1.0 O A:PRO470 4.0 41.4 1.0 OE2 A:GLU490 4.0 45.0 1.0 CA A:THR474 4.1 43.9 1.0 C A:PRO470 4.1 38.8 1.0 N A:HIS469 4.2 43.4 1.0 O A:GLN468 4.2 47.9 1.0 CA A:PRO470 4.2 43.1 1.0 C A:ILE473 4.2 52.8 1.0 N A:PRO470 4.3 42.2 1.0 N A:ILE472 4.3 36.6 1.0 CA A:GLN468 4.3 48.6 1.0 CG2 A:THR474 4.4 58.9 1.0 O A:ILE473 4.5 54.5 1.0 N A:GLN468 4.5 55.4 1.0 CA A:HIS469 4.6 36.4 1.0 CA A:ILE472 4.6 37.4 1.0 N A:ILE473 4.8 38.4 1.0 CA A:ILE473 4.8 40.5 1.0 N A:ASN471 4.8 29.9 1.0 NE A:ARG554 4.8 46.7 1.0 CA A:GLY467 4.9 52.8 1.0 CB A:ILE472 4.9 39.0 1.0

Sodium binding site 2 out of 3 in the Crystal Structure of the Human Ribosomal Protein S6 Kinase


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of the Human Ribosomal Protein S6 Kinase within 5.0Å range: probe atom residue distance (Å) B Occ B:Na1710 b:52.5 occ:1.00 OG1 B:THR474 2.7 53.1 1.0 O B:ILE472 2.7 36.7 1.0 O B:HIS469 2.7 43.4 1.0 O B:GLY467 3.1 59.1 1.0 C B:HIS469 3.7 49.9 1.0 CB B:THR474 3.8 49.8 1.0 O B:PRO470 3.9 38.4 1.0 C B:ILE472 3.9 34.9 1.0 OE2 B:GLU490 3.9 31.3 1.0 N B:THR474 4.0 39.9 1.0 C B:PRO470 4.1 41.4 1.0 C B:GLY467 4.1 53.0 1.0 CA B:THR474 4.1 44.5 1.0 CA B:PRO470 4.1 49.6 1.0 C B:GLN468 4.2 48.1 1.0 O B:GLN468 4.3 54.4 1.0 C B:ILE473 4.3 47.7 1.0 N B:PRO470 4.3 62.6 1.0 N B:ILE472 4.3 30.9 1.0 N B:HIS469 4.4 50.0 1.0 CG2 B:THR474 4.4 43.5 1.0 CA B:GLN468 4.5 54.5 1.0 NE B:ARG554 4.6 43.6 1.0 O B:ILE473 4.6 45.3 1.0 CA B:ILE472 4.7 31.4 1.0 N B:GLN468 4.7 51.9 1.0 CA B:HIS469 4.7 43.6 1.0 N B:ASN471 4.8 42.5 1.0 CA B:ILE473 4.8 40.1 1.0 N B:ILE473 4.9 34.6 1.0 CD B:ARG554 4.9 42.7 1.0 CD B:GLU490 5.0 55.4 1.0

Sodium binding site 3 out of 3 in the Crystal Structure of the Human Ribosomal Protein S6 Kinase


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Crystal Structure of the Human Ribosomal Protein S6 Kinase within 5.0Å range: probe atom residue distance (Å) B Occ B:Na1711 b:36.6 occ:1.00 OG1 B:THR701 2.8 35.4 1.0 N B:PHE614 2.9 31.6 1.0 OG1 B:THR612 2.9 30.7 1.0 CB B:THR612 3.3 28.2 1.0 N B:ALA615 3.4 31.2 1.0 CD B:PRO613 3.4 30.8 1.0 CA B:PHE614 3.5 32.6 1.0 CB B:PHE614 3.5 32.2 1.0 CG2 B:THR701 3.6 33.8 1.0 C B:PHE614 3.7 33.1 1.0 N B:PRO613 3.7 28.8 1.0 CB B:THR701 3.7 32.0 1.0 C B:THR612 4.0 30.4 1.0 CD2 B:PHE614 4.0 30.1 1.0 C B:PRO613 4.0 30.1 1.0 CB B:ALA615 4.0 32.3 1.0 CA B:THR612 4.2 29.4 1.0 CG B:PHE614 4.2 30.6 1.0 CA B:ALA615 4.3 31.6 1.0 CA B:PRO613 4.4 29.1 1.0 CG B:PRO613 4.4 27.5 1.0 CG2 B:THR612 4.4 30.1 1.0 O B:ALA697 4.5 41.5 1.0 O B:PHE614 4.6 33.6 1.0 O B:THR612 4.6 31.0 1.0 CB B:PRO613 4.8 28.2 1.0 O B:ALA615 4.9 36.5 1.0

J.R.C.Muniz, J.M.Elkins, J.Wang, E.Ugochukwu, E.Salah, O.King, S.Picaud, F.Von Delft, C.Bountra, C.H.Arrowsmith, J.Weigelt, A.Edwards, S.Knapp. Crystal Structure of the Human Ribosomal Protein S6 Kinase To Be Published.