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Sodium in PDB 2h34: Apoenzyme Crystal Structure of the Tuberculosis Serine/Threonine Kinase, Pkne

Enzymatic activity of Apoenzyme Crystal Structure of the Tuberculosis Serine/Threonine Kinase, Pkne

All present enzymatic activity of Apoenzyme Crystal Structure of the Tuberculosis Serine/Threonine Kinase, Pkne:
2.7.11.1;

Protein crystallography data

The structure of Apoenzyme Crystal Structure of the Tuberculosis Serine/Threonine Kinase, Pkne, PDB code: 2h34 was solved by L.M.Gay, H.L.Ng, T.Alber, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 34.10 / 2.80
Space group P 65
Cell size a, b, c (Å), α, β, γ (°) 77.078, 77.078, 221.024, 90.00, 90.00, 120.00
R / Rfree (%) 21.6 / 26.5

Other elements in 2h34:

The structure of Apoenzyme Crystal Structure of the Tuberculosis Serine/Threonine Kinase, Pkne also contains other interesting chemical elements:

Bromine (Br) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the Apoenzyme Crystal Structure of the Tuberculosis Serine/Threonine Kinase, Pkne (pdb code 2h34). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Apoenzyme Crystal Structure of the Tuberculosis Serine/Threonine Kinase, Pkne, PDB code: 2h34:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in 2h34

Go back to Sodium Binding Sites List in 2h34
Sodium binding site 1 out of 2 in the Apoenzyme Crystal Structure of the Tuberculosis Serine/Threonine Kinase, Pkne


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Apoenzyme Crystal Structure of the Tuberculosis Serine/Threonine Kinase, Pkne within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na301

b:53.7
occ:1.00
OD1 A:ASP197 3.5 80.0 1.0
OD2 A:ASP197 3.5 79.0 1.0
CD1 A:ILE198 3.6 77.0 1.0
CG A:ASP197 3.9 79.0 1.0
OD1 A:ASP128 4.0 67.5 1.0
CG1 A:ILE198 4.0 76.9 1.0
CB A:HIS131 4.0 70.3 1.0
CB A:ARG195 4.2 83.1 1.0
CG A:HIS131 4.2 71.0 1.0
ND1 A:HIS131 4.5 71.6 1.0
SG A:CYS264 4.6 73.2 1.0
CA A:ASP128 4.7 67.5 1.0
N A:CYS264 4.7 71.4 1.0
O A:LEU127 4.7 68.9 1.0
O A:VAL262 4.7 70.2 1.0
CD2 A:HIS131 4.8 70.9 1.0
N A:ASP128 4.9 67.6 1.0
C A:LEU127 4.9 68.0 1.0
CA A:THR263 4.9 70.8 1.0

Sodium binding site 2 out of 2 in 2h34

Go back to Sodium Binding Sites List in 2h34
Sodium binding site 2 out of 2 in the Apoenzyme Crystal Structure of the Tuberculosis Serine/Threonine Kinase, Pkne


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Apoenzyme Crystal Structure of the Tuberculosis Serine/Threonine Kinase, Pkne within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Na290

b:59.4
occ:1.00
OD2 B:ASP197 2.9 79.0 1.0
OD1 B:ASP128 3.5 66.5 1.0
CB B:HIS131 3.5 63.8 1.0
CG B:HIS131 3.7 65.2 1.0
CG B:ASP197 3.7 76.1 1.0
OD1 B:ASP197 3.8 77.4 1.0
ND1 B:HIS131 4.1 65.2 1.0
CD2 B:HIS131 4.2 64.7 1.0
CD1 B:ILE198 4.3 68.3 1.0
O B:LEU127 4.4 62.9 1.0
CA B:ASP128 4.5 62.2 1.0
O B:TYR194 4.5 83.7 1.0
CG B:ASP128 4.5 65.2 1.0
CG1 B:ILE198 4.6 70.1 1.0
C B:LEU127 4.7 62.3 1.0
O B:VAL262 4.8 71.4 1.0
CE1 B:HIS131 4.8 65.1 1.0
NE2 B:HIS131 4.8 64.2 1.0
N B:ASP128 4.8 62.0 1.0
CA B:HIS131 4.9 63.6 1.0
N B:CYS264 4.9 70.2 1.0
SG B:CYS264 4.9 72.4 1.0

Reference:

L.M.Gay, H.L.Ng, T.Alber. A Conserved Dimer and Global Conformational Changes in the Structure of Apo-Pkne Ser/Thr Protein Kinase From Mycobacterium Tuberculosis. J.Mol.Biol. V. 360 409 2006.
ISSN: ISSN 0022-2836
PubMed: 16762364
DOI: 10.1016/J.JMB.2006.05.015
Page generated: Mon Oct 7 02:43:42 2024

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