Sodium in PDB 2f53: Directed Evolution of Human T-Cell Receptor CDR2 Residues By Phage Display Dramatically Enhances Affinity For Cognate Peptide-Mhc Without Apparent Cross-Reactivity

The structure of Directed Evolution of Human T-Cell Receptor CDR2 Residues By Phage Display Dramatically Enhances Affinity For Cognate Peptide-Mhc Without Apparent Cross-Reactivity, PDB code: 2f53 was solved by P.J.Rizkallah, B.K.Jakobsen, S.M.Dunn, M.Sami, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.85 / 2.10
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	76.234, 53.972, 119.905, 90.00, 96.83, 90.00
R / Rfree (%)	16.6 / 23.1

The binding sites of Sodium atom in the Directed Evolution of Human T-Cell Receptor CDR2 Residues By Phage Display Dramatically Enhances Affinity For Cognate Peptide-Mhc Without Apparent Cross-Reactivity (pdb code 2f53). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Directed Evolution of Human T-Cell Receptor CDR2 Residues By Phage Display Dramatically Enhances Affinity For Cognate Peptide-Mhc Without Apparent Cross-Reactivity, PDB code: 2f53:

Sodium binding site 1 out of 1 in the Directed Evolution of Human T-Cell Receptor CDR2 Residues By Phage Display Dramatically Enhances Affinity For Cognate Peptide-Mhc Without Apparent Cross-Reactivity


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Directed Evolution of Human T-Cell Receptor CDR2 Residues By Phage Display Dramatically Enhances Affinity For Cognate Peptide-Mhc Without Apparent Cross-Reactivity within 5.0Å range: probe atom residue distance (Å) B Occ A:Na801 b:27.0 occ:1.00 OE1 A:GLN155 2.1 26.0 1.0 O C:HOH18 2.4 25.1 1.0 OG1 C:THR7 2.8 2.0 1.0 CD A:GLN155 3.0 16.8 1.0 O C:HOH13 3.1 10.1 1.0 O C:TRP5 3.3 5.0 1.0 N C:THR7 3.6 7.4 1.0 CB C:THR7 3.7 2.3 1.0 CB A:GLN155 3.7 8.1 1.0 NE2 A:GLN155 3.7 13.9 1.0 C C:TRP5 3.8 4.4 1.0 CG A:GLN155 3.9 17.1 1.0 CA C:ILE6 3.9 6.9 1.0 C C:ILE6 4.0 6.4 1.0 N C:ILE6 4.1 4.0 1.0 OH D:TYR30 4.1 11.9 1.0 CG1 A:VAL152 4.2 5.3 1.0 CA C:THR7 4.3 2.0 1.0 N E:ASN96 4.6 3.4 1.0 CG2 A:VAL152 4.6 6.0 1.0 CB C:TRP5 4.6 2.9 1.0 CA E:GLY95 4.6 2.0 1.0 CA A:VAL152 4.7 8.6 1.0 CB A:VAL152 4.7 7.2 1.0 O A:VAL152 4.8 5.6 1.0 CA C:TRP5 4.9 2.8 1.0 O C:ILE6 4.9 5.4 1.0 CG2 C:THR7 5.0 2.0 1.0

S.M.Dunn, P.J.Rizkallah, E.Baston, T.Mahon, B.Cameron, R.Moysey, F.Gao, M.Sami, J.Boulter, Y.Li, B.K.Jakobsen. Directed Evolution of Human T Cell Receptor CDR2 Residues By Phage Display Dramatically Enhances Affinity For Cognate Peptide-Mhc Without Increasing Apparent Cross-Reactivity. Protein Sci. V. 15 710 2006.
ISSN: ISSN 0961-8368
PubMed: 16600963
DOI: 10.1110/PS.051936406