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Sodium in PDB 1eat: Nonpeptidic Inhibitors of Human Leukocyte Elastase. 5. Design, Synthesis, and X-Ray Crystallography of A Series of Orally Active 5- Amino-Pyrimidin-6-One-Containing Trifluoromethylketones
Enzymatic activity of Nonpeptidic Inhibitors of Human Leukocyte Elastase. 5. Design, Synthesis, and X-Ray Crystallography of A Series of Orally Active 5- Amino-Pyrimidin-6-One-Containing Trifluoromethylketones
All present enzymatic activity of Nonpeptidic Inhibitors of Human Leukocyte Elastase. 5. Design, Synthesis, and X-Ray Crystallography of A Series of Orally Active 5- Amino-Pyrimidin-6-One-Containing Trifluoromethylketones:
3.4.21.36;
3.4.21.36;
Protein crystallography data
The structure of Nonpeptidic Inhibitors of Human Leukocyte Elastase. 5. Design, Synthesis, and X-Ray Crystallography of A Series of Orally Active 5- Amino-Pyrimidin-6-One-Containing Trifluoromethylketones, PDB code: 1eat
was solved by
C.Ceccarelli,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 10.00 / 2.00 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 51.990, 57.790, 75.720, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 16.7 / n/a |
Other elements in 1eat:
The structure of Nonpeptidic Inhibitors of Human Leukocyte Elastase. 5. Design, Synthesis, and X-Ray Crystallography of A Series of Orally Active 5- Amino-Pyrimidin-6-One-Containing Trifluoromethylketones also contains other interesting chemical elements:
| Fluorine | (F) | 3 atoms |
Sodium Binding Sites:
The binding sites of Sodium atom in the Nonpeptidic Inhibitors of Human Leukocyte Elastase. 5. Design, Synthesis, and X-Ray Crystallography of A Series of Orally Active 5- Amino-Pyrimidin-6-One-Containing Trifluoromethylketones
(pdb code 1eat). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Nonpeptidic Inhibitors of Human Leukocyte Elastase. 5. Design, Synthesis, and X-Ray Crystallography of A Series of Orally Active 5- Amino-Pyrimidin-6-One-Containing Trifluoromethylketones, PDB code: 1eat:
In total only one binding site of Sodium was determined in the Nonpeptidic Inhibitors of Human Leukocyte Elastase. 5. Design, Synthesis, and X-Ray Crystallography of A Series of Orally Active 5- Amino-Pyrimidin-6-One-Containing Trifluoromethylketones, PDB code: 1eat:
Sodium binding site 1 out of 1 in 1eat
Go back to
Sodium Binding Sites List in 1eat
Sodium binding site 1 out
of 1 in the Nonpeptidic Inhibitors of Human Leukocyte Elastase. 5. Design, Synthesis, and X-Ray Crystallography of A Series of Orally Active 5- Amino-Pyrimidin-6-One-Containing Trifluoromethylketones
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 1 of Nonpeptidic Inhibitors of Human Leukocyte Elastase. 5. Design, Synthesis, and X-Ray Crystallography of A Series of Orally Active 5- Amino-Pyrimidin-6-One-Containing Trifluoromethylketones within 5.0Å range:
|
Reference:
C.A.Veale,
P.R.Bernstein,
C.Bryant,
C.Ceccarelli,
J.R.Damewood Jr.,
R.Earley,
S.W.Feeney,
B.Gomes,
B.J.Kosmider,
G.B.Steelman,
R.M.Thomas,
E.P.Vacek,
J.C.Williams,
D.J.Wolanin,
S.Woolson.
Nonpeptidic Inhibitors of Human Leukocyte Elastase. 5. Design, Synthesis, and X-Ray Crystallography of A Series of Orally Active 5-Aminopyrimidin-6-One-Containing Trifluoromethyl Ketones. J.Med.Chem. V. 38 98 1995.
ISSN: ISSN 0022-2623
PubMed: 7837246
DOI: 10.1021/JM00001A015
Page generated: Sun Oct 6 18:21:43 2024
ISSN: ISSN 0022-2623
PubMed: 7837246
DOI: 10.1021/JM00001A015
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