Sodium in PDB 1btk: pH Domain and Btk Motif From Bruton'S Tyrosine Kinase Mutant R28C

All present enzymatic activity of pH Domain and Btk Motif From Bruton'S Tyrosine Kinase Mutant R28C:
2.7.1.112;

The structure of pH Domain and Btk Motif From Bruton'S Tyrosine Kinase Mutant R28C, PDB code: 1btk was solved by M.Hyvonen, M.Saraste, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.50 / 1.60
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	49.150, 59.870, 55.940, 90.00, 98.21, 90.00
R / Rfree (%)	23.1 / 28.2

The structure of pH Domain and Btk Motif From Bruton'S Tyrosine Kinase Mutant R28C also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Sodium atom in the pH Domain and Btk Motif From Bruton'S Tyrosine Kinase Mutant R28C (pdb code 1btk). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the pH Domain and Btk Motif From Bruton'S Tyrosine Kinase Mutant R28C, PDB code: 1btk:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the pH Domain and Btk Motif From Bruton'S Tyrosine Kinase Mutant R28C


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of pH Domain and Btk Motif From Bruton'S Tyrosine Kinase Mutant R28C within 5.0Å range: probe atom residue distance (Å) B Occ A:Na171 b:30.0 occ:1.00 O A:HOH209 2.4 15.6 1.0 O B:HOH251 2.4 31.0 1.0 O B:HOH222 2.4 23.5 1.0 OE1 A:GLU96 2.5 17.3 1.0 O B:HOH232 2.6 34.9 1.0 CD A:GLU96 3.4 18.0 1.0 OE2 A:GLU96 3.6 17.4 1.0 O B:HOH236 4.0 36.6 1.0 O A:HOH237 4.1 35.9 1.0 CG2 A:ILE92 4.4 13.3 1.0 OE2 B:GLU7 4.4 23.3 1.0 OE1 B:GLU7 4.5 23.3 1.0 O B:GLY47 4.5 24.2 1.0 CG A:GLU96 4.8 15.1 1.0 CD B:GLU7 4.9 19.9 1.0

Sodium binding site 2 out of 2 in the pH Domain and Btk Motif From Bruton'S Tyrosine Kinase Mutant R28C


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of pH Domain and Btk Motif From Bruton'S Tyrosine Kinase Mutant R28C within 5.0Å range: probe atom residue distance (Å) B Occ B:Na181 b:23.2 occ:1.00 O A:HOH262 2.3 15.6 1.0 O A:HOH244 2.3 17.9 1.0 OE1 B:GLU96 2.4 11.9 1.0 O B:HOH252 2.4 17.2 1.0 O A:HOH267 2.4 22.8 1.0 O B:HOH212 2.4 27.7 1.0 CD B:GLU96 3.2 12.5 1.0 OE2 B:GLU96 3.2 14.3 1.0 O B:HOH278 4.0 45.2 1.0 O B:HOH186 4.0 19.3 1.0 O A:HOH203 4.1 20.6 1.0 OE2 A:GLU7 4.2 15.4 1.0 O A:HOH208 4.4 34.6 1.0 O A:GLY47 4.4 18.4 1.0 O A:HOH283 4.5 30.7 1.0 OE1 A:GLU7 4.5 16.2 1.0 CG B:GLU96 4.6 12.3 1.0 CG2 B:ILE92 4.6 13.1 1.0 CD A:GLU7 4.8 14.5 1.0

M.Hyvonen, M.Saraste. Structure of the pH Domain and Btk Motif From Bruton'S Tyrosine Kinase: Molecular Explanations For X-Linked Agammaglobulinaemia. Embo J. V. 16 3396 1997.
ISSN: ISSN 0261-4189
PubMed: 9218782
DOI: 10.1093/EMBOJ/16.12.3396