Sodium in PDB 9p4z: Human EAAT3 with Sodium Bound at Inward Facing State

The binding sites of Sodium atom in the Human EAAT3 with Sodium Bound at Inward Facing State (pdb code 9p4z). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Human EAAT3 with Sodium Bound at Inward Facing State, PDB code: 9p4z:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Human EAAT3 with Sodium Bound at Inward Facing State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Human EAAT3 with Sodium Bound at Inward Facing State within 5.0Å range: probe atom residue distance (Å) B Occ A:Na601 b:81.3 occ:1.00 OD1 A:ASP455 2.2 77.4 1.0 O A:ASN451 2.2 66.9 1.0 O A:ASN366 2.3 68.1 1.0 OD2 A:ASP455 2.5 74.9 1.0 CG A:ASP455 2.6 75.7 1.0 C A:ASN451 2.9 65.8 1.0 O A:GLY362 3.1 62.0 1.0 C A:ASN366 3.4 66.5 1.0 CA A:ASN451 3.5 65.7 1.0 CB A:ASN451 3.6 66.0 1.0 CB A:ASN366 3.8 65.5 1.0 N A:VAL452 3.8 66.8 1.0 CB A:ASP455 4.0 75.0 1.0 C A:GLY362 4.1 64.9 1.0 CA A:ASN366 4.1 67.6 1.0 OG A:SER333 4.2 77.9 1.0 N A:ASP455 4.2 72.8 1.0 CA A:VAL452 4.2 68.6 1.0 N A:MET367 4.4 65.8 1.0 CG A:ASN366 4.6 65.4 1.0 CA A:ASP455 4.7 73.2 1.0 CA A:MET367 4.7 66.4 1.0 CG A:ASN451 4.7 62.7 1.0 N A:ASN366 4.7 62.9 1.0 ND2 A:ASN366 4.8 66.0 1.0 CA A:GLY362 4.8 66.9 1.0 N A:ALA363 4.9 72.5 1.0 CA A:ALA363 4.9 77.7 1.0 N A:ASN451 4.9 63.5 1.0 C A:VAL452 5.0 67.9 1.0

Sodium binding site 2 out of 2 in the Human EAAT3 with Sodium Bound at Inward Facing State


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Human EAAT3 with Sodium Bound at Inward Facing State within 5.0Å range: probe atom residue distance (Å) B Occ A:Na602 b:55.8 occ:1.00 OD1 A:ASP368 2.0 61.2 1.0 OG1 A:THR102 2.1 55.4 1.0 OG1 A:THR101 2.2 61.5 1.0 N A:THR102 2.2 55.9 1.0 OD1 A:ASN366 2.4 69.0 1.0 CA A:THR102 2.6 60.8 1.0 CG A:ASP368 2.7 62.2 1.0 CB A:THR102 2.8 60.2 1.0 C A:THR101 2.9 55.4 1.0 O A:TYR98 3.1 65.0 1.0 OD2 A:ASP368 3.1 63.8 1.0 CB A:THR101 3.3 60.4 1.0 CA A:THR101 3.6 57.8 1.0 CG A:ASN366 3.6 65.4 1.0 O A:THR101 3.7 56.0 1.0 CB A:ASP368 3.9 56.4 1.0 CG2 A:THR102 4.0 56.8 1.0 C A:THR102 4.1 57.1 1.0 CA A:ASP368 4.2 58.4 1.0 N A:THR101 4.2 62.4 1.0 C A:TYR98 4.2 60.8 1.0 ND2 A:ASN366 4.3 66.0 1.0 N A:ASP368 4.3 66.5 1.0 CG2 A:THR101 4.5 60.4 1.0 N A:MET367 4.7 65.8 1.0 CA A:ASN366 4.7 67.6 1.0 C A:MET367 4.7 68.9 1.0 CB A:ASN366 4.7 65.5 1.0 CA A:TYR98 4.8 59.2 1.0 N A:LEU103 4.8 48.1 1.0 O A:THR102 4.9 58.6 1.0 C A:ASN366 5.0 66.5 1.0

P.Koochaki, B.Qiu, J.A.Coker, A.Earsley, N.S.Wang, T.Romigh, C.M.Goins, S.R.Stauffer, O.Boudker, A.A.Chakraborty. Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer. Biorxiv 2025.
ISSN: ISSN 2692-8205
PubMed: 40672197
DOI: 10.1101/2025.07.03.663021