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Atomistry » Sodium » PDB 8tb2-8u2z » 8tx0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Sodium » PDB 8tb2-8u2z » 8tx0 » |
Sodium in PDB 8tx0: IRAK4 in Complex with CompoundEnzymatic activity of IRAK4 in Complex with Compound
All present enzymatic activity of IRAK4 in Complex with Compound:
2.7.11.1; Protein crystallography data
The structure of IRAK4 in Complex with Compound, PDB code: 8tx0
was solved by
C.M.Metrick,
J.V.Chodaparambil,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Sodium Binding Sites:
The binding sites of Sodium atom in the IRAK4 in Complex with Compound
(pdb code 8tx0). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the IRAK4 in Complex with Compound, PDB code: 8tx0: Sodium binding site 1 out of 1 in 8tx0Go back to Sodium Binding Sites List in 8tx0
Sodium binding site 1 out
of 1 in the IRAK4 in Complex with Compound
Mono view Stereo pair view
Reference:
M.Pfaffenbach,
P.N.Bolduc,
Z.Xin,
F.Gao,
R.Evans,
T.Fang,
J.V.Chodaparambil,
K.L.Henry,
P.Li,
S.Mathieu,
C.Metrick,
J.A.Vera Rebollar,
R.F.Gu,
C.A.Mccarl,
J.Silbereis,
E.A.Peterson.
Discovery of Bio-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor For the Treatment of Neuroinflammation. J.Med.Chem. V. 67 8383 2024.
Page generated: Wed Oct 9 13:45:14 2024
ISSN: ISSN 0022-2623 PubMed: 38695469 DOI: 10.1021/ACS.JMEDCHEM.4C00560 |
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