Sodium in PDB 8p3d: Full Length Structure of Tcmip with Bound Inhibitor NJS224.
Enzymatic activity of Full Length Structure of Tcmip with Bound Inhibitor NJS224.
All present enzymatic activity of Full Length Structure of Tcmip with Bound Inhibitor NJS224.:
5.2.1.8;
Protein crystallography data
The structure of Full Length Structure of Tcmip with Bound Inhibitor NJS224., PDB code: 8p3d
was solved by
J.J.Whittaker,
A.Guskov,
B.Goretzki,
U.A.Hellmich,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
46.77 /
1.71
|
Space group
|
P 1 21 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
46.858,
34.696,
53.081,
90,
93.53,
90
|
R / Rfree (%)
|
18.2 /
21.7
|
Other elements in 8p3d:
The structure of Full Length Structure of Tcmip with Bound Inhibitor NJS224. also contains other interesting chemical elements:
Sodium Binding Sites:
The binding sites of Sodium atom in the Full Length Structure of Tcmip with Bound Inhibitor NJS224.
(pdb code 8p3d). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 4 binding sites of Sodium where determined in the
Full Length Structure of Tcmip with Bound Inhibitor NJS224., PDB code: 8p3d:
Jump to Sodium binding site number:
1;
2;
3;
4;
Sodium binding site 1 out
of 4 in 8p3d
Go back to
Sodium Binding Sites List in 8p3d
Sodium binding site 1 out
of 4 in the Full Length Structure of Tcmip with Bound Inhibitor NJS224.
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 1 of Full Length Structure of Tcmip with Bound Inhibitor NJS224. within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Na202
b:26.2
occ:1.00
|
H
|
A:SER130
|
2.2
|
22.8
|
1.0
|
O
|
A:GLY118
|
2.7
|
20.6
|
1.0
|
O
|
A:PRO127
|
2.8
|
21.6
|
1.0
|
NA
|
A:NA203
|
2.8
|
28.1
|
1.0
|
HA2
|
A:GLY121
|
2.8
|
25.6
|
1.0
|
H
|
A:TYR129
|
2.8
|
22.1
|
1.0
|
HB2
|
A:SER130
|
3.0
|
22.9
|
1.0
|
N
|
A:SER130
|
3.0
|
19.0
|
1.0
|
N
|
A:TYR129
|
3.2
|
18.4
|
1.0
|
HG22
|
A:ILE126
|
3.2
|
25.4
|
1.0
|
HA
|
A:PRO128
|
3.3
|
22.3
|
1.0
|
HB2
|
A:TYR117
|
3.4
|
26.9
|
1.0
|
HB2
|
A:TYR113
|
3.5
|
24.8
|
1.0
|
H
|
A:GLY121
|
3.5
|
24.6
|
1.0
|
H
|
A:GLY118
|
3.5
|
23.5
|
1.0
|
N
|
A:GLY118
|
3.6
|
19.6
|
1.0
|
C
|
A:PRO128
|
3.6
|
19.5
|
1.0
|
CA
|
A:GLY121
|
3.7
|
21.3
|
1.0
|
HG
|
A:SER130
|
3.7
|
24.9
|
1.0
|
CB
|
A:SER130
|
3.7
|
19.1
|
1.0
|
C
|
A:TYR117
|
3.7
|
23.4
|
1.0
|
C
|
A:GLY118
|
3.8
|
23.1
|
1.0
|
CA
|
A:PRO128
|
3.8
|
18.6
|
1.0
|
C
|
A:PRO127
|
3.8
|
20.8
|
1.0
|
CA
|
A:SER130
|
3.9
|
17.0
|
1.0
|
HA
|
A:TYR129
|
3.9
|
24.6
|
1.0
|
N
|
A:GLY121
|
3.9
|
20.5
|
1.0
|
CA
|
A:TYR129
|
3.9
|
20.5
|
1.0
|
C
|
A:TYR129
|
3.9
|
16.4
|
1.0
|
O
|
A:SER130
|
4.0
|
19.2
|
1.0
|
HG21
|
A:ILE126
|
4.0
|
25.4
|
1.0
|
O
|
A:TYR117
|
4.0
|
25.6
|
1.0
|
H
|
A:TYR117
|
4.0
|
22.0
|
1.0
|
HA3
|
A:GLY121
|
4.0
|
25.6
|
1.0
|
CG2
|
A:ILE126
|
4.0
|
21.1
|
1.0
|
CB
|
A:TYR117
|
4.1
|
22.4
|
1.0
|
OG
|
A:SER130
|
4.1
|
20.7
|
1.0
|
CA
|
A:GLY118
|
4.2
|
21.9
|
1.0
|
HB3
|
A:TYR117
|
4.2
|
26.9
|
1.0
|
N
|
A:PRO128
|
4.3
|
19.4
|
1.0
|
CA
|
A:TYR117
|
4.3
|
19.9
|
1.0
|
O
|
A:PRO128
|
4.4
|
19.6
|
1.0
|
HG23
|
A:ILE126
|
4.4
|
25.4
|
1.0
|
CB
|
A:TYR113
|
4.4
|
20.7
|
1.0
|
C
|
A:SER130
|
4.4
|
16.3
|
1.0
|
N
|
A:TYR117
|
4.5
|
18.4
|
1.0
|
HA2
|
A:GLY118
|
4.5
|
26.3
|
1.0
|
HB3
|
A:SER130
|
4.5
|
22.9
|
1.0
|
HB3
|
A:TYR113
|
4.5
|
24.8
|
1.0
|
HA
|
A:TYR113
|
4.6
|
21.4
|
1.0
|
HA
|
A:SER130
|
4.7
|
20.4
|
1.0
|
O
|
A:ILE126
|
4.8
|
22.2
|
1.0
|
C
|
A:GLY121
|
4.8
|
24.0
|
1.0
|
N
|
A:VAL119
|
4.9
|
21.5
|
1.0
|
HD2
|
A:TYR113
|
5.0
|
34.3
|
1.0
|
|
Sodium binding site 2 out
of 4 in 8p3d
Go back to
Sodium Binding Sites List in 8p3d
Sodium binding site 2 out
of 4 in the Full Length Structure of Tcmip with Bound Inhibitor NJS224.
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 2 of Full Length Structure of Tcmip with Bound Inhibitor NJS224. within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Na203
b:28.1
occ:1.00
|
H
|
A:TYR117
|
2.1
|
22.0
|
1.0
|
HB3
|
A:ALA116
|
2.7
|
19.6
|
1.0
|
HB2
|
A:TYR117
|
2.7
|
26.9
|
1.0
|
O
|
A:SER130
|
2.8
|
19.2
|
1.0
|
NA
|
A:NA202
|
2.8
|
26.2
|
1.0
|
N
|
A:TYR117
|
2.9
|
18.4
|
1.0
|
HB1
|
A:ALA116
|
3.0
|
19.6
|
1.0
|
HG21
|
A:ILE126
|
3.1
|
25.4
|
1.0
|
HB2
|
A:SER130
|
3.1
|
22.9
|
1.0
|
CB
|
A:ALA116
|
3.2
|
16.3
|
1.0
|
H
|
A:GLY118
|
3.3
|
23.5
|
1.0
|
HD21
|
A:LEU132
|
3.3
|
22.4
|
1.0
|
HG
|
A:LEU132
|
3.3
|
19.1
|
1.0
|
HD2
|
A:TYR117
|
3.4
|
23.6
|
1.0
|
HA
|
A:TYR113
|
3.4
|
21.4
|
1.0
|
HD11
|
A:LEU132
|
3.5
|
20.4
|
1.0
|
CB
|
A:TYR117
|
3.5
|
22.4
|
1.0
|
H
|
A:SER130
|
3.6
|
22.8
|
1.0
|
HG22
|
A:ILE126
|
3.6
|
25.4
|
1.0
|
CA
|
A:TYR117
|
3.6
|
19.9
|
1.0
|
CG2
|
A:ILE126
|
3.7
|
21.1
|
1.0
|
N
|
A:GLY118
|
3.8
|
19.6
|
1.0
|
C
|
A:SER130
|
3.8
|
16.3
|
1.0
|
HG23
|
A:ILE126
|
3.9
|
25.4
|
1.0
|
CB
|
A:SER130
|
3.9
|
19.1
|
1.0
|
HB2
|
A:TYR113
|
3.9
|
24.8
|
1.0
|
C
|
A:TYR117
|
3.9
|
23.4
|
1.0
|
CG
|
A:LEU132
|
3.9
|
15.9
|
1.0
|
C
|
A:ALA116
|
3.9
|
20.0
|
1.0
|
HB2
|
A:ALA116
|
4.0
|
19.6
|
1.0
|
CD2
|
A:LEU132
|
4.0
|
18.6
|
1.0
|
CD1
|
A:LEU132
|
4.1
|
17.0
|
1.0
|
CD2
|
A:TYR117
|
4.1
|
19.6
|
1.0
|
CA
|
A:ALA116
|
4.2
|
21.0
|
1.0
|
N
|
A:SER130
|
4.2
|
19.0
|
1.0
|
CA
|
A:SER130
|
4.2
|
17.0
|
1.0
|
HB3
|
A:TYR117
|
4.2
|
26.9
|
1.0
|
HB3
|
A:SER130
|
4.2
|
22.9
|
1.0
|
CA
|
A:TYR113
|
4.3
|
17.8
|
1.0
|
O
|
A:TYR113
|
4.3
|
20.8
|
1.0
|
HD23
|
A:LEU132
|
4.3
|
22.4
|
1.0
|
CG
|
A:TYR117
|
4.3
|
21.9
|
1.0
|
HA2
|
A:GLY121
|
4.4
|
25.6
|
1.0
|
HA
|
A:TYR117
|
4.5
|
23.9
|
1.0
|
CB
|
A:TYR113
|
4.5
|
20.7
|
1.0
|
HD13
|
A:ILE126
|
4.5
|
24.7
|
1.0
|
HD12
|
A:LEU132
|
4.5
|
20.4
|
1.0
|
HB3
|
A:TYR113
|
4.7
|
24.8
|
1.0
|
H
|
A:ALA116
|
4.8
|
25.7
|
1.0
|
HD22
|
A:LEU132
|
4.8
|
22.4
|
1.0
|
C
|
A:TYR113
|
4.8
|
22.6
|
1.0
|
O
|
A:GLY118
|
4.8
|
20.6
|
1.0
|
O
|
A:TYR117
|
4.8
|
25.6
|
1.0
|
HA
|
A:ALA116
|
4.9
|
25.2
|
1.0
|
O
|
A:PRO127
|
4.9
|
21.6
|
1.0
|
HD13
|
A:LEU132
|
4.9
|
20.4
|
1.0
|
HA
|
A:PRO131
|
4.9
|
20.6
|
1.0
|
N
|
A:PRO131
|
5.0
|
19.8
|
1.0
|
OG
|
A:SER130
|
5.0
|
20.7
|
1.0
|
|
Sodium binding site 3 out
of 4 in 8p3d
Go back to
Sodium Binding Sites List in 8p3d
Sodium binding site 3 out
of 4 in the Full Length Structure of Tcmip with Bound Inhibitor NJS224.
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 3 of Full Length Structure of Tcmip with Bound Inhibitor NJS224. within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Na204
b:34.9
occ:1.00
|
HH11
|
A:ARG102
|
2.5
|
41.4
|
1.0
|
HZ2
|
A:TRP107
|
2.5
|
28.6
|
1.0
|
OD2
|
A:ASP105
|
2.7
|
24.9
|
1.0
|
O
|
A:HOH400
|
2.7
|
27.9
|
1.0
|
O
|
A:LEU100
|
2.9
|
26.0
|
1.0
|
NH1
|
A:ARG102
|
2.9
|
34.5
|
1.0
|
HA
|
A:MET101
|
3.1
|
26.2
|
1.0
|
HD3
|
A:ARG102
|
3.1
|
50.1
|
1.0
|
HH12
|
A:ARG102
|
3.1
|
41.4
|
1.0
|
HG11
|
A:VAL153
|
3.2
|
35.4
|
1.0
|
CZ2
|
A:TRP107
|
3.3
|
23.8
|
1.0
|
HG12
|
A:VAL153
|
3.5
|
35.4
|
1.0
|
HD11
|
A:LEU157
|
3.5
|
34.6
|
1.0
|
CG
|
A:ASP105
|
3.7
|
26.8
|
1.0
|
HD12
|
A:LEU157
|
3.7
|
34.6
|
1.0
|
HE1
|
A:TRP107
|
3.8
|
28.5
|
1.0
|
CG1
|
A:VAL153
|
3.8
|
29.5
|
1.0
|
H
|
A:ARG102
|
3.8
|
32.6
|
1.0
|
CZ
|
A:ARG102
|
3.8
|
36.6
|
1.0
|
CD
|
A:ARG102
|
3.9
|
41.8
|
1.0
|
O
|
A:HOH342
|
3.9
|
34.0
|
1.0
|
CA
|
A:MET101
|
4.0
|
21.9
|
1.0
|
C
|
A:LEU100
|
4.0
|
24.3
|
1.0
|
CE2
|
A:TRP107
|
4.0
|
20.2
|
1.0
|
HD2
|
A:ARG102
|
4.0
|
50.1
|
1.0
|
CD1
|
A:LEU157
|
4.1
|
28.8
|
1.0
|
OD1
|
A:ASP105
|
4.1
|
28.4
|
1.0
|
NE
|
A:ARG102
|
4.2
|
44.1
|
1.0
|
NE1
|
A:TRP107
|
4.2
|
23.8
|
1.0
|
CH2
|
A:TRP107
|
4.2
|
24.4
|
1.0
|
HH2
|
A:TRP107
|
4.2
|
29.3
|
1.0
|
HG13
|
A:VAL153
|
4.2
|
35.4
|
1.0
|
N
|
A:ARG102
|
4.4
|
27.2
|
1.0
|
HD13
|
A:LEU157
|
4.4
|
34.6
|
1.0
|
HG2
|
A:MET101
|
4.4
|
24.3
|
1.0
|
N
|
A:MET101
|
4.5
|
25.1
|
1.0
|
C
|
A:MET101
|
4.6
|
25.9
|
1.0
|
HE
|
A:ARG43
|
4.6
|
30.1
|
1.0
|
O
|
A:HOH341
|
4.7
|
45.4
|
1.0
|
HB3
|
A:ASP105
|
4.7
|
24.2
|
1.0
|
NH2
|
A:ARG102
|
4.8
|
34.9
|
1.0
|
CB
|
A:ASP105
|
4.8
|
20.2
|
1.0
|
HB2
|
A:ARG102
|
4.8
|
30.9
|
1.0
|
HB3
|
A:LEU100
|
4.8
|
29.9
|
1.0
|
OD1
|
A:ASP154
|
4.9
|
37.7
|
1.0
|
HH22
|
A:ARG102
|
4.9
|
41.8
|
1.0
|
HB
|
A:VAL153
|
4.9
|
35.1
|
1.0
|
HE
|
A:ARG102
|
4.9
|
52.9
|
1.0
|
CB
|
A:MET101
|
5.0
|
22.4
|
1.0
|
CB
|
A:VAL153
|
5.0
|
29.2
|
1.0
|
|
Sodium binding site 4 out
of 4 in 8p3d
Go back to
Sodium Binding Sites List in 8p3d
Sodium binding site 4 out
of 4 in the Full Length Structure of Tcmip with Bound Inhibitor NJS224.
Mono view
Stereo pair view
|
A full contact list of Sodium with other atoms in the Na binding
site number 4 of Full Length Structure of Tcmip with Bound Inhibitor NJS224. within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Na205
b:33.9
occ:1.00
|
O
|
A:HOH439
|
2.4
|
42.0
|
1.0
|
OE1
|
A:GLU133
|
2.7
|
24.8
|
1.0
|
O
|
A:LEU67
|
2.8
|
20.5
|
1.0
|
HA2
|
A:GLY70
|
3.1
|
25.5
|
1.0
|
H
|
A:GLY70
|
3.2
|
24.0
|
1.0
|
HB3
|
A:ARG66
|
3.5
|
24.0
|
1.0
|
CD
|
A:GLU133
|
3.5
|
33.0
|
1.0
|
HB3
|
A:GLU133
|
3.6
|
22.9
|
1.0
|
HA
|
A:ARG68
|
3.6
|
23.9
|
1.0
|
HB2
|
A:ARG66
|
3.6
|
24.0
|
1.0
|
N
|
A:GLY70
|
3.7
|
20.0
|
1.0
|
HE1
|
A:PHE22
|
3.7
|
31.0
|
1.0
|
HZ
|
A:PHE22
|
3.7
|
27.8
|
1.0
|
CA
|
A:GLY70
|
3.8
|
21.3
|
1.0
|
O
|
A:ARG68
|
3.9
|
24.0
|
1.0
|
HD3
|
A:ARG66
|
3.9
|
35.5
|
1.0
|
C
|
A:LEU67
|
3.9
|
15.3
|
1.0
|
HB2
|
A:GLU133
|
3.9
|
22.9
|
1.0
|
CB
|
A:ARG66
|
4.0
|
20.0
|
1.0
|
C
|
A:ARG68
|
4.0
|
21.2
|
1.0
|
OE2
|
A:GLU133
|
4.1
|
33.3
|
1.0
|
CB
|
A:GLU133
|
4.1
|
19.0
|
1.0
|
O
|
A:HOH353
|
4.2
|
45.0
|
1.0
|
CA
|
A:ARG68
|
4.2
|
19.9
|
1.0
|
CE1
|
A:PHE22
|
4.3
|
25.8
|
1.0
|
HA3
|
A:GLY70
|
4.3
|
25.5
|
1.0
|
CZ
|
A:PHE22
|
4.3
|
23.2
|
1.0
|
HD2
|
A:ARG66
|
4.3
|
35.5
|
1.0
|
CG
|
A:GLU133
|
4.4
|
17.9
|
1.0
|
CD
|
A:ARG66
|
4.5
|
29.6
|
1.0
|
N
|
A:ARG68
|
4.5
|
17.8
|
1.0
|
N
|
A:ASP69
|
4.7
|
20.8
|
1.0
|
C
|
A:ASP69
|
4.7
|
27.7
|
1.0
|
C
|
A:ARG66
|
4.8
|
18.4
|
1.0
|
HE3
|
A:LYS26
|
4.8
|
38.6
|
1.0
|
HG2
|
A:GLU133
|
4.8
|
21.4
|
1.0
|
O
|
A:ARG66
|
4.9
|
17.5
|
1.0
|
C
|
A:GLY70
|
4.9
|
23.5
|
1.0
|
CG
|
A:ARG66
|
4.9
|
24.0
|
1.0
|
N
|
A:LEU67
|
5.0
|
18.6
|
1.0
|
|
Reference:
J.J.Whittaker,
A.Guskov,
B.Goretzki,
U.A.Hellmich.
Structural Dynamics of Macrophage Infectivity Potentiator Proteins (Mips) Are Differentially Modulated By Inhibitors and Appendage Domains To Be Published.
Page generated: Wed Oct 9 12:51:55 2024
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