Sodium in PDB 8hv1: Crystal Structure of EGFR_DMX in Complex with Covalently Bound Fragment 1

Enzymatic activity of Crystal Structure of EGFR_DMX in Complex with Covalently Bound Fragment 1

All present enzymatic activity of Crystal Structure of EGFR_DMX in Complex with Covalently Bound Fragment 1:
2.7.10.1;

Protein crystallography data

The structure of Crystal Structure of EGFR_DMX in Complex with Covalently Bound Fragment 1, PDB code: 8hv1 was solved by P.Dokurno, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	25.00 / 2.40
*Space group*	I 2 3
*Cell size a, b, c (Å), α, β, γ (°)*	144.91, 144.91, 144.91, 90, 90, 90
*R / R_free (%)*	18.9 / 21.9

Other elements in 8hv1:

The structure of Crystal Structure of EGFR_DMX in Complex with Covalently Bound Fragment 1 also contains other interesting chemical elements:

Bromine

(Br)

1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of EGFR_DMX in Complex with Covalently Bound Fragment 1 (pdb code 8hv1). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of EGFR_DMX in Complex with Covalently Bound Fragment 1, PDB code: 8hv1:

Sodium binding site 1 out of 1 in 8hv1

Go back to

Sodium Binding Sites List in 8hv1

Sodium binding site 1 out of 1 in the Crystal Structure of EGFR_DMX in Complex with Covalently Bound Fragment 1

Mono view

Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of EGFR_DMX in Complex with Covalently Bound Fragment 1 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Na1103 b:77.2 occ:1.00	O	A:HOH1241	2.3	59.0	1.0
	O	A:HOH1216	2.4	45.9	1.0
	O	A:HOH1251	2.7	55.9	1.0
	OG	A:SER899	2.9	48.8	1.0
	O	A:HOH1227	3.0	40.1	1.0
	O	A:SER895	3.6	44.2	1.0
	CA	A:ARG836	3.9	47.9	1.0
	OD1	A:ASP896	4.0	46.6	1.0
	CB	A:SER899	4.0	45.1	1.0
	O	A:ARG836	4.1	51.5	1.0
	C	A:ARG836	4.1	46.9	1.0
	C	A:SER895	4.2	43.1	1.0
	OG	A:SER895	4.3	59.8	1.0
	CE2	A:TYR891	4.3	54.2	1.0
	CD2	A:TYR891	4.3	45.2	1.0
	O	A:TRP880	4.4	52.5	1.0
	CA	A:MET881	4.4	52.7	1.0
	CG	A:MET881	4.4	65.4	1.0
	N	A:ASP896	4.6	41.8	1.0
	CA	A:ASP896	4.6	49.3	1.0
	N	A:ASP837	4.8	42.7	1.0
	CB	A:SER895	4.8	47.1	1.0
	N	A:ARG836	4.8	51.1	1.0
	N	A:ALA882	4.8	45.4	1.0
	CB	A:MET881	4.9	60.7	1.0
	CB	A:ARG836	4.9	56.3	1.0

Reference:

N.Kuki, D.L.Walmsley, K.Kanai, S.Takechi, M.Yoshida, R.Murakami, K.Takano, Y.Tominaga, M.Takahashi, S.Ito, N.Nakao, H.Angove, L.M.Baker, E.Carter, P.Dokurno, L.L.Strat, A.T.Macias, C.A.Molyneaux, J.B.Murray, A.E.Surgenor, T.Hamada, R.E.Hubbard. A Covalent Fragment-Based Strategy Targeting A Novel Cysteine to Inhibit Activity of Mutant Egfr Kinase. Rsc Med Chem 2023.
ISSN: ESSN 2632-8682
DOI: 10.1039/D3MD00439B

Page generated: Wed Oct 9 12:17:32 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy