Sodium in PDB 8ha1: Crystal Structure of Voltage-Gated Sodium Channel Navab N49K/L176G Mutant in Sodium Ion Condition

The structure of Crystal Structure of Voltage-Gated Sodium Channel Navab N49K/L176G Mutant in Sodium Ion Condition, PDB code: 8ha1 was solved by K.Irie, Y.Oda, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.91 / 3.50
Space group	I 4 2 2
Cell size a, b, c (Å), α, β, γ (°)	126.91, 126.91, 201.78, 90, 90, 90
R / Rfree (%)	29.1 / 29.7

The binding sites of Sodium atom in the Crystal Structure of Voltage-Gated Sodium Channel Navab N49K/L176G Mutant in Sodium Ion Condition (pdb code 8ha1). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 2 binding sites of Sodium where determined in the Crystal Structure of Voltage-Gated Sodium Channel Navab N49K/L176G Mutant in Sodium Ion Condition, PDB code: 8ha1:
Jump to Sodium binding site number: 1; 2;

Sodium binding site 1 out of 2 in the Crystal Structure of Voltage-Gated Sodium Channel Navab N49K/L176G Mutant in Sodium Ion Condition


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Voltage-Gated Sodium Channel Navab N49K/L176G Mutant in Sodium Ion Condition within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1312 b:149.1 occ:0.25 O A:GLY1176 4.2 133.9 1.0 O6' A:LMT1301 4.3 157.2 1.0 NA A:NA1313 4.8 114.3 0.2 O A:THR1175 5.0 127.8 1.0

Sodium binding site 2 out of 2 in the Crystal Structure of Voltage-Gated Sodium Channel Navab N49K/L176G Mutant in Sodium Ion Condition


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of Voltage-Gated Sodium Channel Navab N49K/L176G Mutant in Sodium Ion Condition within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1313 b:114.3 occ:0.25 N A:SER1178 4.6 108.7 1.0 CG A:GLU1177 4.7 107.9 1.0 CA A:GLU1177 4.8 115.3 1.0 NA A:NA1312 4.8 149.1 0.2 OG A:SER1178 4.9 114.3 1.0 O A:GLY1176 4.9 133.9 1.0

K.Irie, Y.Oda, T.Sumikama, A.Oshima, Y.Fujiyoshi. The Structural Basis of Divalent Cation Block in A Tetrameric Prokaryotic Sodium Channel. Nat Commun V. 14 4236 2023.
ISSN: ESSN 2041-1723
PubMed: 37454189
DOI: 10.1038/S41467-023-39987-0