Sodium in PDB 7bvq: Structure of Human BETA1 Adrenergic Receptor Bound to Carazolol

All present enzymatic activity of Structure of Human BETA1 Adrenergic Receptor Bound to Carazolol:
3.2.1.17;

The structure of Structure of Human BETA1 Adrenergic Receptor Bound to Carazolol, PDB code: 7bvq was solved by X.Xu, J.Kaindl, M.Clark, H.Hubner, K.Hirata, R.Sunahara, P.Gmeiner, B.K.Kobilka, X.Liu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.79 / 2.50
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	52.134, 52.825, 142.749, 92.14, 90.71, 116.65
R / Rfree (%)	22.5 / 26.3

The binding sites of Sodium atom in the Structure of Human BETA1 Adrenergic Receptor Bound to Carazolol (pdb code 7bvq). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Structure of Human BETA1 Adrenergic Receptor Bound to Carazolol, PDB code: 7bvq:

Sodium binding site 1 out of 1 in the Structure of Human BETA1 Adrenergic Receptor Bound to Carazolol


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Structure of Human BETA1 Adrenergic Receptor Bound to Carazolol within 5.0Å range: probe atom residue distance (Å) B Occ A:Na1410 b:47.1 occ:1.00 O A:CYS1215 2.2 45.0 1.0 O A:HOH1576 2.2 40.8 1.0 O A:HOH1530 2.4 47.4 1.0 O A:CYS1209 2.5 44.0 1.0 O A:HOH1513 2.6 44.1 1.0 O A:ASP1212 2.8 43.4 1.0 C A:CYS1215 3.3 45.9 1.0 C A:CYS1209 3.6 46.5 1.0 C A:ASP1212 3.8 46.7 1.0 SG A:CYS1209 4.0 63.2 1.0 CA A:TYR1210 4.1 44.7 1.0 CA A:CYS1215 4.1 43.0 1.0 CB A:CYS1215 4.2 39.5 1.0 N A:TYR1210 4.3 39.6 1.0 N A:CYS1216 4.3 39.7 1.0 N A:CYS1215 4.3 42.8 1.0 O A:TYR1210 4.3 44.0 1.0 C A:TYR1210 4.3 43.9 1.0 CA A:PRO1213 4.4 46.7 1.0 CA A:CYS1216 4.4 42.6 1.0 O A:PRO1213 4.5 47.1 1.0 N A:PRO1213 4.5 45.5 1.0 C A:PRO1213 4.5 48.4 1.0 CA A:CYS1209 4.6 39.7 1.0 N A:ASP1212 4.6 41.4 1.0 SG A:CYS1131 4.6 47.0 1.0 OG A:SER1128 4.8 46.0 1.0 CA A:ASP1212 4.8 46.5 1.0 CB A:CYS1209 4.8 43.3 1.0 SG A:CYS1215 4.9 47.8 1.0

X.Xu, J.Kaindl, M.J.Clark, H.Hubner, K.Hirata, R.K.Sunahara, P.Gmeiner, B.K.Kobilka, X.Liu. Binding Pathway Determines Norepinephrine Selectivity For the Human Beta 1 Ar Over Beta 2 Ar. Cell Res. 2020.
ISSN: ISSN 1001-0602
PubMed: 33093660
DOI: 10.1038/S41422-020-00424-2