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PDB 6zl4-7a2n »
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Sodium in PDB 6ztb: Crystal Structure of Human P-Cadherin EC1_EC2
Protein crystallography data
The structure of Crystal Structure of Human P-Cadherin EC1_EC2, PDB code: 6ztb
was solved by
J.M.Rondeau,
S.Lehmann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 57.55 / 1.40 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 120.889, 76.522, 46.208, 90, 107.79, 90 |
| R / Rfree (%) | 19.8 / 21.4 |
Other elements in 6ztb:
The structure of Crystal Structure of Human P-Cadherin EC1_EC2 also contains other interesting chemical elements:
| Calcium | (Ca) | 3 atoms |
Sodium Binding Sites:
The binding sites of Sodium atom in the Crystal Structure of Human P-Cadherin EC1_EC2
(pdb code 6ztb). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total 4 binding sites of Sodium where determined in the Crystal Structure of Human P-Cadherin EC1_EC2, PDB code: 6ztb:
Jump to Sodium binding site number: 1; 2; 3; 4;
In total 4 binding sites of Sodium where determined in the Crystal Structure of Human P-Cadherin EC1_EC2, PDB code: 6ztb:
Jump to Sodium binding site number: 1; 2; 3; 4;
Sodium binding site 1 out of 4 in 6ztb
Go back to
Sodium Binding Sites List in 6ztb
Sodium binding site 1 out
of 4 in the Crystal Structure of Human P-Cadherin EC1_EC2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 1 of Crystal Structure of Human P-Cadherin EC1_EC2 within 5.0Å range:
|
Sodium binding site 2 out of 4 in 6ztb
Go back to
Sodium Binding Sites List in 6ztb
Sodium binding site 2 out
of 4 in the Crystal Structure of Human P-Cadherin EC1_EC2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 2 of Crystal Structure of Human P-Cadherin EC1_EC2 within 5.0Å range:
|
Sodium binding site 3 out of 4 in 6ztb
Go back to
Sodium Binding Sites List in 6ztb
Sodium binding site 3 out
of 4 in the Crystal Structure of Human P-Cadherin EC1_EC2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 3 of Crystal Structure of Human P-Cadherin EC1_EC2 within 5.0Å range:
|
Sodium binding site 4 out of 4 in 6ztb
Go back to
Sodium Binding Sites List in 6ztb
Sodium binding site 4 out
of 4 in the Crystal Structure of Human P-Cadherin EC1_EC2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 4 of Crystal Structure of Human P-Cadherin EC1_EC2 within 5.0Å range:
|
Reference:
Q.Sheng,
J.A.D'alessio,
D.L.Menezes,
C.Karim,
Y.Tang,
A.Tam,
S.Clark,
C.Ying,
A.Connor,
K.G.Mansfield,
J.M.Rondeau,
M.Ghoddusi,
F.C.Geyer,
J.Gu,
M.E.Mclaughlin,
R.Newcombe,
G.Elliott,
W.R.Tschantz,
S.Lehmann,
K.Miller,
T.Huber,
K.G.Rendahl,
U.Jeffry,
N.K.Pryer,
E.Lees,
P.Kwon,
J.A.Abraham,
J.S.Damiano,
T.J.Abrams.
PCA062, A P-Cadherin Targeting Antibody-Drug-Conjugate, Displays Potent Anti-Tumor Activity Against P-Cadherin-Expressing Malignancies. Mol.Cancer Ther. 2021.
ISSN: ESSN 1538-8514
PubMed: 33879555
DOI: 10.1158/1535-7163.MCT-20-0708
Page generated: Tue Oct 8 15:40:01 2024
ISSN: ESSN 1538-8514
PubMed: 33879555
DOI: 10.1158/1535-7163.MCT-20-0708
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