Atomistry » Sodium » PDB 6wnx-6xbh » 6wx5
Atomistry »
  Sodium »
    PDB 6wnx-6xbh »
      6wx5 »

Sodium in PDB 6wx5: Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl

Enzymatic activity of Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl

All present enzymatic activity of Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl:
3.2.1.17;

Protein crystallography data

The structure of Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl, PDB code: 6wx5 was solved by M.P.Sullivan, C.G.Hartinger, D.C.Goldstone, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 34.61 / 1.30
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 77.329, 77.329, 38.606, 90, 90, 90
R / Rfree (%) 17.4 / 20.2

Other elements in 6wx5:

The structure of Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl also contains other interesting chemical elements:

Platinum (Pt) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl (pdb code 6wx5). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl, PDB code: 6wx5:

Sodium binding site 1 out of 1 in 6wx5

Go back to Sodium Binding Sites List in 6wx5
Sodium binding site 1 out of 1 in the Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na201

b:16.3
occ:1.00
O A:SER60 2.3 16.6 1.0
O A:HOH375 2.4 21.2 1.0
OG A:SER72 2.4 21.1 1.0
O A:CYS64 2.4 15.8 1.0
O A:ARG73 2.5 18.4 1.0
O A:ACT202 2.8 18.2 1.0
CB A:SER72 3.4 21.7 1.0
C A:SER60 3.4 12.5 1.0
C A:CYS64 3.5 13.5 1.0
C A:ARG73 3.5 19.6 1.0
C A:ACT202 3.7 18.4 1.0
CH3 A:ACT202 3.9 19.2 1.0
N A:ARG73 3.9 25.0 1.0
CA A:ASN65 4.0 13.3 1.0
CA A:SER60 4.0 13.0 1.0
N A:ASN65 4.1 13.2 1.0
C A:SER72 4.1 23.5 1.0
CB A:SER60 4.2 12.2 1.0
N A:CYS64 4.3 13.5 1.0
CA A:ARG73 4.3 23.0 1.0
N A:ASN74 4.3 17.3 1.0
CA A:SER72 4.4 22.6 1.0
C A:ARG61 4.5 15.0 1.0
N A:ARG61 4.5 14.1 1.0
O A:HOH378 4.5 34.8 1.0
CA A:ASN74 4.5 17.0 1.0
O A:ARG61 4.5 17.7 1.0
CA A:CYS64 4.5 12.7 1.0
CB A:THR69 4.6 15.8 1.0
O A:SER72 4.7 25.7 1.0
CB A:ASN74 4.7 17.6 1.0
O A:THR69 4.7 20.3 1.0
N A:TRP62 4.8 14.6 1.0
CA A:ARG61 4.8 14.9 0.4
CA A:ARG61 4.8 15.3 0.6
OXT A:ACT202 4.9 20.5 1.0
CB A:ASN65 4.9 15.7 1.0
CG2 A:THR69 4.9 17.7 1.0
N A:TRP63 4.9 13.7 1.0
N A:ASP66 5.0 13.1 1.0
C A:TRP62 5.0 14.1 1.0

Reference:

M.Adams, M.P.Sullivan, K.K.H.Tong, D.C.Goldstone, M.Hanif, S.M.F.Jamieson, C.G.Hartinger. Mustards-Derived Terpyridine-Platinum Complexes As Anticancer Agents: Dna Alkylation Vs Coordination. Inorg.Chem. 2021.
ISSN: ISSN 0020-1669
PubMed: 33497565
DOI: 10.1021/ACS.INORGCHEM.0C03317
Page generated: Tue Oct 8 14:42:56 2024

Last articles

As in 1TR7
As in 1TA4
As in 1SNG
As in 1SK0
As in 1SJZ
As in 1SK1
As in 1S6C
As in 1RA7
As in 1SIJ
As in 1RA6
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy