Sodium in PDB 6t81: Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide.

All present enzymatic activity of Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide.:
4.2.1.1;

The structure of Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide., PDB code: 6t81 was solved by A.Smirnov, E.Manakova, S.Grazulis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.64 / 0.98
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	42.032, 41.009, 71.684, 90.00, 104.13, 90.00
R / Rfree (%)	14.6 / 17.2

The structure of Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide. also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Sodium atom in the Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide. (pdb code 6t81). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide., PDB code: 6t81:

Sodium binding site 1 out of 1 in the Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide.


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide. within 5.0Å range: probe atom residue distance (Å) B Occ A:Na305 b:18.4 occ:1.00 O A:HOH613 2.0 35.0 1.0 O A:HOH467 2.3 21.8 1.0 OG A:SER220 2.4 11.3 0.5 O A:HOH518 2.5 15.8 1.0 CB A:SER220 3.5 11.5 0.5 CB A:SER220 3.6 12.8 0.5 OE1 A:GLU221 3.8 23.3 1.0 N A:SER220 4.1 9.8 0.5 N A:SER220 4.1 9.7 0.5 O A:HOH607 4.2 19.8 1.0 CA A:SER220 4.4 11.4 0.5 CD A:GLU221 4.4 31.1 1.0 CA A:SER220 4.5 10.2 0.5 OE2 A:GLU221 4.5 38.3 1.0 OG A:SER220 4.6 14.7 0.5 O A:GLY151 4.9 11.2 1.0

V.Dudutiene, A.Zubriene, V.Kairys, A.Smirnov, J.Smirnoviene, J.Leitans, A.Kazaks, K.Tars, L.Manakova, S.Grazulis, D.Matulis. Isoform-Selective Enzyme Inhibitors By Exploring Pocket Size According to the Lock-and-Key Principle. Biophys.J. V. 119 1513 2020.
ISSN: ESSN 1542-0086
PubMed: 32971003
DOI: 10.1016/J.BPJ.2020.08.037