Atomistry » Sodium » PDB 6sxe-6tbi » 6t81
Atomistry »
  Sodium »
    PDB 6sxe-6tbi »
      6t81 »

Sodium in PDB 6t81: Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide.

Enzymatic activity of Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide.

All present enzymatic activity of Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide.:
4.2.1.1;

Protein crystallography data

The structure of Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide., PDB code: 6t81 was solved by A.Smirnov, E.Manakova, S.Grazulis, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.64 / 0.98
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.032, 41.009, 71.684, 90.00, 104.13, 90.00
R / Rfree (%) 14.6 / 17.2

Other elements in 6t81:

The structure of Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide. also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide. (pdb code 6t81). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide., PDB code: 6t81:

Sodium binding site 1 out of 1 in 6t81

Go back to Sodium Binding Sites List in 6t81
Sodium binding site 1 out of 1 in the Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide.


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Human Carbonic Anhydrase II Bound By 2-Naphthalenesulfonamide. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na305

b:18.4
occ:1.00
O A:HOH613 2.0 35.0 1.0
O A:HOH467 2.3 21.8 1.0
OG A:SER220 2.4 11.3 0.5
O A:HOH518 2.5 15.8 1.0
CB A:SER220 3.5 11.5 0.5
CB A:SER220 3.6 12.8 0.5
OE1 A:GLU221 3.8 23.3 1.0
N A:SER220 4.1 9.8 0.5
N A:SER220 4.1 9.7 0.5
O A:HOH607 4.2 19.8 1.0
CA A:SER220 4.4 11.4 0.5
CD A:GLU221 4.4 31.1 1.0
CA A:SER220 4.5 10.2 0.5
OE2 A:GLU221 4.5 38.3 1.0
OG A:SER220 4.6 14.7 0.5
O A:GLY151 4.9 11.2 1.0

Reference:

V.Dudutiene, A.Zubriene, V.Kairys, A.Smirnov, J.Smirnoviene, J.Leitans, A.Kazaks, K.Tars, L.Manakova, S.Grazulis, D.Matulis. Isoform-Selective Enzyme Inhibitors By Exploring Pocket Size According to the Lock-and-Key Principle. Biophys.J. V. 119 1513 2020.
ISSN: ESSN 1542-0086
PubMed: 32971003
DOI: 10.1016/J.BPJ.2020.08.037
Page generated: Tue Dec 15 13:04:35 2020

Last articles

Zn in 7VD8
Zn in 7V1R
Zn in 7V1Q
Zn in 7VPF
Zn in 7T85
Zn in 7T5F
Zn in 7NF9
Zn in 7M4M
Zn in 7M4O
Zn in 7M4N
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy