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Sodium in PDB 6sxg: Crystal Structure of the Voltage-Gated Sodium Channel Navms in Complex with 4-Hydroxytamoxifen (2.4 Angstrom Resolution)

Protein crystallography data

The structure of Crystal Structure of the Voltage-Gated Sodium Channel Navms in Complex with 4-Hydroxytamoxifen (2.4 Angstrom Resolution), PDB code: 6sxg was solved by A.Sula, D.Hollingworth, B.A.Wallace, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.76 / 2.40
Space group I 4 2 2
Cell size a, b, c (Å), α, β, γ (°) 108.91, 108.91, 211.292, 90, 90, 90
R / Rfree (%) 22.1 / 26.1

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of the Voltage-Gated Sodium Channel Navms in Complex with 4-Hydroxytamoxifen (2.4 Angstrom Resolution) (pdb code 6sxg). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 3 binding sites of Sodium where determined in the Crystal Structure of the Voltage-Gated Sodium Channel Navms in Complex with 4-Hydroxytamoxifen (2.4 Angstrom Resolution), PDB code: 6sxg:
Jump to Sodium binding site number: 1; 2; 3;

Sodium binding site 1 out of 3 in 6sxg

Go back to Sodium Binding Sites List in 6sxg
Sodium binding site 1 out of 3 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms in Complex with 4-Hydroxytamoxifen (2.4 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of the Voltage-Gated Sodium Channel Navms in Complex with 4-Hydroxytamoxifen (2.4 Angstrom Resolution) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na301

b:83.9
occ:0.25
NA A:NA302 3.2 125.3 0.2
CD1 A:LEU177 4.7 37.8 1.0
O A:THR176 5.0 40.8 1.0

Sodium binding site 2 out of 3 in 6sxg

Go back to Sodium Binding Sites List in 6sxg
Sodium binding site 2 out of 3 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms in Complex with 4-Hydroxytamoxifen (2.4 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of the Voltage-Gated Sodium Channel Navms in Complex with 4-Hydroxytamoxifen (2.4 Angstrom Resolution) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na302

b:125.3
occ:0.25
NA A:NA303 2.5 69.4 0.2
NA A:NA301 3.2 83.9 0.2
O A:LEU177 4.5 38.3 1.0
O A:THR176 4.9 40.8 1.0
CB A:LEU177 5.0 35.6 1.0

Sodium binding site 3 out of 3 in 6sxg

Go back to Sodium Binding Sites List in 6sxg
Sodium binding site 3 out of 3 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms in Complex with 4-Hydroxytamoxifen (2.4 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Crystal Structure of the Voltage-Gated Sodium Channel Navms in Complex with 4-Hydroxytamoxifen (2.4 Angstrom Resolution) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na303

b:69.4
occ:0.25
NA A:NA302 2.5 125.3 0.2
O A:LEU177 4.3 38.3 1.0
CA A:GLU178 4.9 34.8 1.0

Reference:

A.Sula, D.Hollingworth, L.C.Ng, M.Larmore, P.G.Decaen, B.A.Wallace. A Tamoxifen Receptor Within A Voltage-Gated Sodium Channel Mol.Cell 2021.
ISSN: ISSN 1097-2765
DOI: 10.1016/J.MOLCEL.2020.12.048
Page generated: Tue Oct 8 13:33:08 2024

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