Sodium in PDB 6sxf: Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution)

Protein crystallography data

The structure of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution), PDB code: 6sxf was solved by A.Sula, D.Hollingworth, B.A.Wallace, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 76.34 / 2.84
Space group P 4 21 2
Cell size a, b, c (Å), α, β, γ (°) 107.956, 107.956, 212.224, 90, 90, 90
R / Rfree (%) 22 / 26.9

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution) (pdb code 6sxf). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 6 binding sites of Sodium where determined in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution), PDB code: 6sxf:
Jump to Sodium binding site number: 1; 2; 3; 4; 5; 6;

Sodium binding site 1 out of 6 in 6sxf

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Sodium binding site 1 out of 6 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na301

b:84.5
occ:0.25
NA A:NA302 2.4 103.5 0.2
O A:THR176 4.8 47.1 1.0

Sodium binding site 2 out of 6 in 6sxf

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Sodium binding site 2 out of 6 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na302

b:103.5
occ:0.25
NA A:NA301 2.4 84.5 0.2
O A:HOH407 4.1 58.7 1.0
O A:LEU177 4.7 43.8 1.0

Sodium binding site 3 out of 6 in 6sxf

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Sodium binding site 3 out of 6 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na303

b:89.6
occ:0.25
O A:HOH407 2.9 58.7 1.0
OG A:SER179 3.9 54.4 1.0
OE2 A:GLU178 4.3 52.8 1.0
N A:SER179 4.7 46.9 1.0
CA A:SER179 5.0 47.1 1.0

Sodium binding site 4 out of 6 in 6sxf

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Sodium binding site 4 out of 6 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Na301

b:59.4
occ:0.25
NA B:NA302 3.0 106.0 0.2
O B:THR176 5.0 45.8 1.0

Sodium binding site 5 out of 6 in 6sxf

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Sodium binding site 5 out of 6 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 5 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Na302

b:106.0
occ:0.25
NA B:NA301 3.0 59.4 0.2
NA B:NA303 3.2 90.0 0.2
O B:LEU177 4.6 42.4 1.0

Sodium binding site 6 out of 6 in 6sxf

Go back to Sodium Binding Sites List in 6sxf
Sodium binding site 6 out of 6 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 6 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Na303

b:90.0
occ:0.25
NA B:NA302 3.2 106.0 0.2
N B:SER179 4.6 44.6 1.0
O B:LEU177 4.9 42.4 1.0
CA B:GLU178 5.0 43.0 1.0

Reference:

A.Sula, D.Hollingworth, L.C.Ng, M.Larmore, P.G.Decaen, B.A.Wallace. A Tamoxifen Receptor Within A Voltage-Gated Sodium Channel Mol.Cell 2021.
ISSN: ISSN 1097-2765
DOI: 10.1016/J.MOLCEL.2020.12.048
Page generated: Wed Mar 3 15:27:24 2021

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