Sodium in PDB 6sxf: Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution)

The structure of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution), PDB code: 6sxf was solved by A.Sula, D.Hollingworth, B.A.Wallace, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	76.34 / 2.84
Space group	P 4 21 2
Cell size a, b, c (Å), α, β, γ (°)	107.956, 107.956, 212.224, 90, 90, 90
R / Rfree (%)	22 / 26.9

The binding sites of Sodium atom in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution) (pdb code 6sxf). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 6 binding sites of Sodium where determined in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution), PDB code: 6sxf:
Jump to Sodium binding site number: 1; 2; 3; 4; 5; 6;

Sodium binding site 1 out of 6 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ A:Na301 b:84.5 occ:0.25 NA A:NA302 2.4 103.5 0.2 O A:THR176 4.8 47.1 1.0

Sodium binding site 2 out of 6 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ A:Na302 b:103.5 occ:0.25 NA A:NA301 2.4 84.5 0.2 O A:HOH407 4.1 58.7 1.0 O A:LEU177 4.7 43.8 1.0

Sodium binding site 3 out of 6 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ A:Na303 b:89.6 occ:0.25 O A:HOH407 2.9 58.7 1.0 OG A:SER179 3.9 54.4 1.0 OE2 A:GLU178 4.3 52.8 1.0 N A:SER179 4.7 46.9 1.0 CA A:SER179 5.0 47.1 1.0

Sodium binding site 4 out of 6 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 4 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ B:Na301 b:59.4 occ:0.25 NA B:NA302 3.0 106.0 0.2 O B:THR176 5.0 45.8 1.0

Sodium binding site 5 out of 6 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 5 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ B:Na302 b:106.0 occ:0.25 NA B:NA301 3.0 59.4 0.2 NA B:NA303 3.2 90.0 0.2 O B:LEU177 4.6 42.4 1.0

Sodium binding site 6 out of 6 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 6 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Tamoxifen (2.8 Angstrom Resolution) within 5.0Å range: probe atom residue distance (Å) B Occ B:Na303 b:90.0 occ:0.25 NA B:NA302 3.2 106.0 0.2 N B:SER179 4.6 44.6 1.0 O B:LEU177 4.9 42.4 1.0 CA B:GLU178 5.0 43.0 1.0

A.Sula, D.Hollingworth, L.C.Ng, M.Larmore, P.G.Decaen, B.A.Wallace. A Tamoxifen Receptor Within A Voltage-Gated Sodium Channel Mol.Cell 2021.
ISSN: ISSN 1097-2765
DOI: 10.1016/J.MOLCEL.2020.12.048