Sodium in PDB 6sxe: Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Endoxifen (2.6 Angstrom Resolution)

Protein crystallography data

The structure of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Endoxifen (2.6 Angstrom Resolution), PDB code: 6sxe was solved by A.Sula, D.Hollingworth, B.A.Wallace, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 52.54 / 2.60
Space group I 4 2 2
Cell size a, b, c (Å), α, β, γ (°) 110.108, 110.108, 210.164, 90, 90, 90
R / Rfree (%) 23.8 / 27.8

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Endoxifen (2.6 Angstrom Resolution) (pdb code 6sxe). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total 3 binding sites of Sodium where determined in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Endoxifen (2.6 Angstrom Resolution), PDB code: 6sxe:
Jump to Sodium binding site number: 1; 2; 3;

Sodium binding site 1 out of 3 in 6sxe

Go back to Sodium Binding Sites List in 6sxe
Sodium binding site 1 out of 3 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Endoxifen (2.6 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Endoxifen (2.6 Angstrom Resolution) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na301

b:121.2
occ:0.25
NA A:NA302 4.6 248.7 0.2
O A:THR176 4.8 58.2 1.0
CD1 A:LEU177 4.9 53.1 1.0

Sodium binding site 2 out of 3 in 6sxe

Go back to Sodium Binding Sites List in 6sxe
Sodium binding site 2 out of 3 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Endoxifen (2.6 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 2 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Endoxifen (2.6 Angstrom Resolution) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na302

b:248.7
occ:0.25
NA A:NA303 2.4 122.0 0.2
O A:LEU177 4.3 58.4 1.0
NA A:NA301 4.6 121.2 0.2
CA A:GLU178 5.0 52.3 1.0

Sodium binding site 3 out of 3 in 6sxe

Go back to Sodium Binding Sites List in 6sxe
Sodium binding site 3 out of 3 in the Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Endoxifen (2.6 Angstrom Resolution)


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 3 of Crystal Structure of the Voltage-Gated Sodium Channel Navms (F208L) in Complex with Endoxifen (2.6 Angstrom Resolution) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na303

b:122.0
occ:0.25
NA A:NA302 2.4 248.7 0.2
OE2 A:GLU178 4.5 69.8 1.0
N A:SER179 4.6 56.1 1.0
OG A:SER179 4.7 65.1 1.0

Reference:

A.Sula, D.Hollingworth, L.C.Ng, M.Larmore, P.G.Decaen, B.A.Wallace. A Tamoxifen Receptor Within A Voltage-Gated Sodium Channel Mol.Cell 2021.
ISSN: ISSN 1097-2765
DOI: 10.1016/J.MOLCEL.2020.12.048
Page generated: Wed Mar 3 15:27:23 2021

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