Sodium in PDB 6sgp: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu

Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu

All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu:
3.4.17.21;

Protein crystallography data

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu, PDB code: 6sgp was solved by C.Barinka, S.Shukla, L.Motlova, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	46.90 / 1.58
*Space group*	I 2 2 2
*Cell size a, b, c (Å), α, β, γ (°)*	101.349, 130.394, 158.538, 90.00, 90.00, 90.00
*R / R_free (%)*	18 / 20.1

Other elements in 6sgp:

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu also contains other interesting chemical elements:

Zinc	(Zn)	2 atoms
Calcium	(Ca)	1 atom
Chlorine	(Cl)	1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu (pdb code 6sgp). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu, PDB code: 6sgp:

Sodium binding site 1 out of 1 in 6sgp

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Sodium Binding Sites List in 6sgp

Sodium binding site 1 out of 1 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu

Mono view

Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Na827 b:51.4 occ:1.00	O	A:HOH1295	2.3	37.4	1.0
	OE1	A:GLU437	2.3	42.0	1.0
	ND2	A:ASN275	2.8	27.5	1.0
	O	A:HOH1301	3.0	40.9	1.0
	O	A:HOH921	3.0	36.2	1.0
	O	A:HOH912	3.2	47.1	1.0
	CD	A:GLU437	3.3	31.6	1.0
	CG	A:PRO273	3.6	20.7	1.0
	CB	A:ASN275	3.7	24.1	1.0
	CG	A:GLU437	3.7	24.7	1.0
	CG	A:ASN275	3.7	23.9	1.0
	CB	A:PRO273	4.3	19.6	1.0
	OH	A:TYR277	4.3	30.5	1.0
	OE2	A:GLU437	4.4	31.1	1.0
	O	A:HOH1209	4.7	24.3	1.0
	CB	A:GLU437	4.7	21.1	1.0
	OD1	A:ASN275	4.9	24.4	1.0
	CZ	A:TYR277	4.9	28.4	1.0
	CE2	A:TYR277	5.0	28.9	1.0

Reference:

C.Barinka, S.Shukla, L.Motlova. X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu To Be Published.

Page generated: Tue Oct 8 13:28:27 2024

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