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Sodium in PDB 6sgp: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu

Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu

All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu:
3.4.17.21;

Protein crystallography data

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu, PDB code: 6sgp was solved by C.Barinka, S.Shukla, L.Motlova, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.90 / 1.58
Space group I 2 2 2
Cell size a, b, c (Å), α, β, γ (°) 101.349, 130.394, 158.538, 90.00, 90.00, 90.00
R / Rfree (%) 18 / 20.1

Other elements in 6sgp:

The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu also contains other interesting chemical elements:

Zinc (Zn) 2 atoms
Calcium (Ca) 1 atom
Chlorine (Cl) 1 atom

Sodium Binding Sites:

The binding sites of Sodium atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu (pdb code 6sgp). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu, PDB code: 6sgp:

Sodium binding site 1 out of 1 in 6sgp

Go back to Sodium Binding Sites List in 6sgp
Sodium binding site 1 out of 1 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na827

b:51.4
occ:1.00
 O A:HOH1295 2.3 37.4 1.0
OE1 A:GLU437 2.3 42.0 1.0
ND2 A:ASN275 2.8 27.5 1.0
O A:HOH1301 3.0 40.9 1.0
O A:HOH921 3.0 36.2 1.0
O A:HOH912 3.2 47.1 1.0
CD A:GLU437 3.3 31.6 1.0
CG A:PRO273 3.6 20.7 1.0
CB A:ASN275 3.7 24.1 1.0
CG A:GLU437 3.7 24.7 1.0
CG A:ASN275 3.7 23.9 1.0
CB A:PRO273 4.3 19.6 1.0
OH A:TYR277 4.3 30.5 1.0
OE2 A:GLU437 4.4 31.1 1.0
O A:HOH1209 4.7 24.3 1.0
CB A:GLU437 4.7 21.1 1.0
OD1 A:ASN275 4.9 24.4 1.0
CZ A:TYR277 4.9 28.4 1.0
CE2 A:TYR277 5.0 28.9 1.0

Reference:

C.Barinka, S.Shukla, L.Motlova. X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) - the E424M Inactive Mutant, in Complex with A Sulfamide Inhibitor Gluglu To Be Published.
Page generated: Tue Oct 8 13:28:27 2024

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