Sodium in PDB 6sfo: MAPK14 with Bound Inhibitor Sr-318

All present enzymatic activity of MAPK14 with Bound Inhibitor Sr-318:
2.7.11.24;

The structure of MAPK14 with Bound Inhibitor Sr-318, PDB code: 6sfo was solved by M.Schroeder, A.M.Edwards, C.H.Arrowsmith, C.Bountra, S.Knapp, Structuralgenomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.40 / 1.75
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	65.516, 75.051, 77.486, 90.00, 90.00, 90.00
R / Rfree (%)	19.1 / 23.6

The binding sites of Sodium atom in the MAPK14 with Bound Inhibitor Sr-318 (pdb code 6sfo). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the MAPK14 with Bound Inhibitor Sr-318, PDB code: 6sfo:

Sodium binding site 1 out of 1 in the MAPK14 with Bound Inhibitor Sr-318


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of MAPK14 with Bound Inhibitor Sr-318 within 5.0Å range: probe atom residue distance (Å) B Occ A:Na401 b:36.5 occ:1.00 O A:ARG149 2.6 26.1 1.0 O A:HOH635 2.7 26.3 1.0 O A:HOH591 2.8 34.1 1.0 NE A:ARG189 3.1 35.4 1.0 O A:HOH601 3.3 23.4 1.0 C A:ARG149 3.5 24.5 1.0 CA A:ARG189 3.5 28.6 1.0 CB A:ARG189 3.5 31.1 1.0 NH2 A:ARG189 3.7 36.5 1.0 CG A:ARG189 3.7 34.8 1.0 CZ A:ARG189 3.8 38.7 1.0 OG A:SER208 3.8 23.1 1.0 CA A:ASP150 4.0 27.0 1.0 CD A:ARG189 4.0 37.4 1.0 N A:ASP150 4.1 24.2 1.0 O A:TYR188 4.2 25.2 1.0 CD1 A:ILE193 4.3 36.8 1.0 N A:ARG189 4.3 28.0 1.0 CA A:ARG149 4.4 25.9 1.0 C A:TYR188 4.4 25.6 1.0 N A:LEU151 4.6 24.3 1.0 CG2 A:THR185 4.6 44.2 1.0 N A:ALA190 4.6 28.4 1.0 OD1 A:ASP150 4.6 37.4 1.0 C A:ARG189 4.6 27.7 1.0 C A:ASP150 4.7 25.6 1.0 O A:THR185 4.7 38.2 1.0 O A:LEU151 4.8 29.6 1.0

M.Schroeder, A.M.Edwards, C.H.Arrowsmith, C.Bountra, S.Knapp, Structural Genomics Consortium (Sgc). MAPK14 with Bound Inhibitor Sr-318 To Be Published.