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Sodium in PDB 6rz4: Crystal Structure of Cysteinyl Leukotriene Receptor 1 in Complex with Pranlukast

Protein crystallography data

The structure of Crystal Structure of Cysteinyl Leukotriene Receptor 1 in Complex with Pranlukast, PDB code: 6rz4 was solved by A.Luginina, A.Gusach, E.Marin, A.Mishin, R.Brouillette, P.Popov, A.Shiryaeva, E.Besserer-Offroy, J.M.Longpre, E.Lyapina, A.Ishchenko, N.Patel, V.Polovinkin, N.Safronova, A.Bogorodskiy, E.Edelweiss, W.Liu, A.Batyuk, V.Gordeliy, G.W.Han, P.Sarret, V.Katritch, V.Borshchevskiy, V.Cherezov, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.30 / 2.70
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 58.630, 45.350, 86.430, 90.00, 91.47, 90.00
R / Rfree (%) 22.8 / 25.4

Sodium Binding Sites:

The binding sites of Sodium atom in the Crystal Structure of Cysteinyl Leukotriene Receptor 1 in Complex with Pranlukast (pdb code 6rz4). This binding sites where shown within 5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Crystal Structure of Cysteinyl Leukotriene Receptor 1 in Complex with Pranlukast, PDB code: 6rz4:

Sodium binding site 1 out of 1 in 6rz4

Go back to Sodium Binding Sites List in 6rz4
Sodium binding site 1 out of 1 in the Crystal Structure of Cysteinyl Leukotriene Receptor 1 in Complex with Pranlukast


Mono view


Stereo pair view

A full contact list of Sodium with other atoms in the Na binding site number 1 of Crystal Structure of Cysteinyl Leukotriene Receptor 1 in Complex with Pranlukast within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Na2002

b:52.5
occ:1.00
OD1 A:ASN396 2.2 69.5 1.0
OD2 A:ASP400 2.3 81.9 1.0
OG A:SER110 2.4 57.3 1.0
OD1 A:ASP69 2.7 66.7 1.0
O A:ASN396 3.1 58.3 1.0
CB A:SER110 3.3 48.4 1.0
CG A:ASN396 3.3 76.6 1.0
CG A:ASP69 3.4 65.9 1.0
OD2 A:ASP69 3.5 72.6 1.0
C A:ASN396 3.5 58.6 1.0
CG A:ASP400 3.5 75.2 1.0
CB A:ASN396 3.9 52.0 1.0
N A:CYS397 3.9 57.4 1.0
CA A:CYS397 4.1 58.2 1.0
ND2 A:ASN106 4.1 57.3 1.0
OD1 A:ASP400 4.2 75.7 1.0
CD2 A:LEU65 4.3 60.6 1.0
CA A:ASN396 4.3 51.7 1.0
CA A:SER110 4.4 44.9 1.0
ND2 A:ASN396 4.4 71.0 1.0
CB A:ASP400 4.6 63.3 1.0
O A:LEU65 4.7 56.1 1.0
OD1 A:ASN106 4.8 58.9 1.0
CG A:ASN106 4.9 65.9 1.0
CB A:ASP69 4.9 55.1 1.0
O A:ASN106 4.9 49.7 1.0
CB A:CYS397 5.0 58.8 1.0

Reference:

A.Luginina, A.Gusach, E.Marin, A.Mishin, R.Brouillette, P.Popov, A.Shiriaeva, E.Besserer-Offroy, J.M.Longpre, E.Lyapina, A.Ishchenko, N.Patel, V.Polovinkin, N.Safronova, A.Bogorodskiy, E.Edelweiss, H.Hu, U.Weierstall, W.Liu, A.Batyuk, V.Gordeliy, G.W.Han, P.Sarret, V.Katritch, V.Borshchevskiy, V.Cherezov. Structure-Based Mechanism of Cysteinyl Leukotriene Receptor Inhibition By Antiasthmatic Drugs. Sci Adv V. 5 X2518 2019.
ISSN: ESSN 2375-2548
PubMed: 31633023
DOI: 10.1126/SCIADV.AAX2518
Page generated: Tue Dec 15 12:56:27 2020

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