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Sodium in PDB 6rmx: Human Carbonic Anhydrase II Mutant T199V Bound By 2-[(1S)-2,3-Dihydro- 1H-Inden-1-Ylamino]-3,5,6-Trifluoro-4-[(2-Hydroxyethyl) Thio]Benzenesulfonamide
Enzymatic activity of Human Carbonic Anhydrase II Mutant T199V Bound By 2-[(1S)-2,3-Dihydro- 1H-Inden-1-Ylamino]-3,5,6-Trifluoro-4-[(2-Hydroxyethyl) Thio]Benzenesulfonamide
All present enzymatic activity of Human Carbonic Anhydrase II Mutant T199V Bound By 2-[(1S)-2,3-Dihydro- 1H-Inden-1-Ylamino]-3,5,6-Trifluoro-4-[(2-Hydroxyethyl) Thio]Benzenesulfonamide:
4.2.1.1;
4.2.1.1;
Protein crystallography data
The structure of Human Carbonic Anhydrase II Mutant T199V Bound By 2-[(1S)-2,3-Dihydro- 1H-Inden-1-Ylamino]-3,5,6-Trifluoro-4-[(2-Hydroxyethyl) Thio]Benzenesulfonamide, PDB code: 6rmx
was solved by
A.Smirnov,
V.Paketuryte,
E.Manakova,
S.Grazulis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.02 / 1.60 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 42.260, 41.050, 71.770, 90.00, 104.14, 90.00 |
| R / Rfree (%) | 17 / 21.3 |
Other elements in 6rmx:
The structure of Human Carbonic Anhydrase II Mutant T199V Bound By 2-[(1S)-2,3-Dihydro- 1H-Inden-1-Ylamino]-3,5,6-Trifluoro-4-[(2-Hydroxyethyl) Thio]Benzenesulfonamide also contains other interesting chemical elements:
| Fluorine | (F) | 3 atoms |
| Zinc | (Zn) | 1 atom |
Sodium Binding Sites:
The binding sites of Sodium atom in the Human Carbonic Anhydrase II Mutant T199V Bound By 2-[(1S)-2,3-Dihydro- 1H-Inden-1-Ylamino]-3,5,6-Trifluoro-4-[(2-Hydroxyethyl) Thio]Benzenesulfonamide
(pdb code 6rmx). This binding sites where shown within
5.0 Angstroms radius around Sodium atom.
In total only one binding site of Sodium was determined in the Human Carbonic Anhydrase II Mutant T199V Bound By 2-[(1S)-2,3-Dihydro- 1H-Inden-1-Ylamino]-3,5,6-Trifluoro-4-[(2-Hydroxyethyl) Thio]Benzenesulfonamide, PDB code: 6rmx:
In total only one binding site of Sodium was determined in the Human Carbonic Anhydrase II Mutant T199V Bound By 2-[(1S)-2,3-Dihydro- 1H-Inden-1-Ylamino]-3,5,6-Trifluoro-4-[(2-Hydroxyethyl) Thio]Benzenesulfonamide, PDB code: 6rmx:
Sodium binding site 1 out of 1 in 6rmx
Go back to
Sodium Binding Sites List in 6rmx
Sodium binding site 1 out
of 1 in the Human Carbonic Anhydrase II Mutant T199V Bound By 2-[(1S)-2,3-Dihydro- 1H-Inden-1-Ylamino]-3,5,6-Trifluoro-4-[(2-Hydroxyethyl) Thio]Benzenesulfonamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Sodium with other atoms in the Na binding
site number 1 of Human Carbonic Anhydrase II Mutant T199V Bound By 2-[(1S)-2,3-Dihydro- 1H-Inden-1-Ylamino]-3,5,6-Trifluoro-4-[(2-Hydroxyethyl) Thio]Benzenesulfonamide within 5.0Å range:
|
Reference:
A.Smirnov,
E.Manakova,
V.Paketuryte.
Human Carbonic Anhydrase II Mutant T199V Bound By 2-[(1S)-2,3-Dihydro-1H-Inden-1-Ylamino]-3,5, 6-Trifluoro-4-[(2-Hydroxyethyl)Thio]Benzenesulfonamide To Be Published.
Page generated: Tue Oct 8 13:16:28 2024
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